SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cek'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 5cek TRIBBLES HOMOLOG 1
(Homo
sapiens) 		5 / 11 LEU A 206
LEU A 314
MET A 273
VAL A 193
ILE A 332
 None
 1.40A 1ee2B-5cekA:
undetectable		 1ee2B-5cekA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N3Z_A_ADNA126_1
(RIBONUCLEASE,
SEMINAL)		 5cek TRIBBLES HOMOLOG 1
(Homo
sapiens) 		5 / 9 ALA A 329
GLN A 188
ALA A 192
VAL A 193
HIS A 195
 None
 1.24A 1n3zA-5cekA:
undetectable		 1n3zA-5cekA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5cek TRIBBLES HOMOLOG 1
(Homo
sapiens) 		5 / 10 HIS A 104
ALA A 156
PHE A 122
GLY A 145
PHE A 160
 None
 1.22A 1uhoA-5cekA:
undetectable		 1uhoA-5cekA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 5cek TRIBBLES HOMOLOG 1
(Homo
sapiens) 		4 / 6 LEU A 333
LEU A 334
LEU A 327
LEU A 270
 None
 0.97A 2ab2A-5cekA:
undetectable		 2ab2A-5cekA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5cek TRIBBLES HOMOLOG 1
(Homo
sapiens) 		4 / 7 ARG A 218
GLY A 165
PHE A 164
GLU A 217
 None
 1.10A 2c8aD-5cekA:
undetectable		 2c8aD-5cekA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 5cek TRIBBLES HOMOLOG 1
(Homo
sapiens) 		5 / 9 VAL A 202
GLY A 204
ILE A 253
TYR A 260
GLY A 262
 None
 1.44A 3csjB-5cekA:
undetectable		 3csjB-5cekA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 5cek TRIBBLES HOMOLOG 1
(Homo
sapiens) 		5 / 11 CYH A 119
LEU A 117
LEU A  96
ALA A 108
ALA A  92
 None
 1.27A 3e22B-5cekA:
undetectable		 3e22B-5cekA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5cek TRIBBLES HOMOLOG 1
(Homo
sapiens) 		4 / 4 TYR A 248
SER A 269
GLU A 252
ASP A 266
 None
 1.46A 5lsaA-5cekA:
undetectable		 5lsaA-5cekA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 5cek TRIBBLES HOMOLOG 1
(Homo
sapiens) 		3 / 3 TYR A 248
HIS A 168
MET A 167
 None
 0.99A 6af6A-5cekA:
undetectable		 6af6A-5cekA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 5cek TRIBBLES HOMOLOG 1
(Homo
sapiens) 		4 / 5 ILE A 307
SER A 308
ALA A 183
LEU A 277
 None
 0.94A 6dwnA-5cekA:
undetectable		 6dwnA-5cekA:
13.60