SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cfa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 8 THR A 211
ALA A 260
THR A 217
ILE A 219
 None
 0.82A 1c9sI-5cfaA:
undetectable
1c9sJ-5cfaA:
undetectable		 1c9sI-5cfaA:
14.65
1c9sJ-5cfaA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 8 THR A 211
ALA A 260
THR A 217
ILE A 219
 None
 0.81A 1gtnE-5cfaA:
undetectable
1gtnF-5cfaA:
undetectable		 1gtnE-5cfaA:
14.65
1gtnF-5cfaA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN
(Staphylococcus
aureus) 		5 / 12 THR A 312
GLN A 175
TYR A 205
GLY A 196
GLY A 209
 None
 1.28A 1httC-5cfaA:
undetectable		 1httC-5cfaA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN
(Staphylococcus
aureus) 		3 / 3 PHE A  69
TYR A  96
PRO A  71
 None
 0.98A 1mcnA-5cfaA:
5.8
1mcnB-5cfaA:
1.2
1mcnP-5cfaA:
undetectable		 1mcnA-5cfaA:
21.89
1mcnB-5cfaA:
21.89
1mcnP-5cfaA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN
(Staphylococcus
aureus) 		5 / 12 GLY A 320
GLY A 321
GLY A 322
ASP A 318
GLY A  85
 None
 0.88A 1n2xB-5cfaA:
undetectable		 1n2xB-5cfaA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 7 ILE A 177
ILE A 159
THR A 189
THR A 297
 None
 0.82A 1sbrB-5cfaA:
2.1		 1sbrB-5cfaA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1352_1
(PROSTAGLANDIN
REDUCTASE 2)		 5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 7 LEU A  89
ASN A  90
LYS A  92
TYR A 237
 None
 1.09A 2w98A-5cfaA:
undetectable
2w98B-5cfaA:
undetectable		 2w98A-5cfaA:
18.67
2w98B-5cfaA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN
(Staphylococcus
aureus) 		5 / 12 VAL A  54
THR A 135
THR A  17
ASN A 115
ILE A  34
 None
 1.07A 3a3bA-5cfaA:
2.3		 3a3bA-5cfaA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 8 VAL A 198
GLY A 292
ILE A 177
GLY A 308
 None
 0.49A 3n9jB-5cfaA:
undetectable		 3n9jB-5cfaA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN
(Staphylococcus
aureus) 		3 / 3 GLN A 149
ASP A  30
GLN A  27
 None
 0.85A 4aztA-5cfaA:
undetectable		 4aztA-5cfaA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 6 HIS A  29
GLU A 174
ASP A 167
ASP A  64
 None
 1.34A 4blvA-5cfaA:
undetectable		 4blvA-5cfaA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN
(Staphylococcus
aureus) 		5 / 11 ALA A 307
TYR A 306
SER A 304
SER A 305
THR A 192
 None
 1.10A 4mmaA-5cfaA:
undetectable		 4mmaA-5cfaA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN
(Staphylococcus
aureus) 		5 / 11 GLY A 321
GLY A 320
GLY A 324
ILE A  82
PHE A  40
 None
 1.13A 4qoiA-5cfaA:
undetectable
4qoiB-5cfaA:
undetectable		 4qoiA-5cfaA:
21.79
4qoiB-5cfaA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 7 THR A 192
GLN A 175
ALA A 260
ILE A 213
 None
 0.94A 4txnA-5cfaA:
undetectable		 4txnA-5cfaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 7 THR A 192
GLN A 175
ALA A 260
ILE A 213
 None
 0.95A 4txnB-5cfaA:
undetectable		 4txnB-5cfaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 7 THR A 192
GLN A 175
ALA A 260
ILE A 213
 None
 0.94A 4txnC-5cfaA:
undetectable		 4txnC-5cfaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 6 SER A 277
GLY A 207
ASP A 208
GLY A 197
 None
 0.75A 5cdnR-5cfaA:
undetectable
5cdnS-5cfaA:
undetectable		 5cdnR-5cfaA:
23.46
5cdnS-5cfaA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN
(Staphylococcus
aureus) 		5 / 12 ALA A  83
GLY A  49
ASP A 323
GLY A 324
ASP A 100
 None
 1.09A 5wwsA-5cfaA:
undetectable		 5wwsA-5cfaA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN
(Staphylococcus
aureus) 		5 / 12 ALA A  83
GLY A  49
ASP A 323
GLY A 324
ASP A 100
 None
 1.09A 5wwsB-5cfaA:
undetectable		 5wwsB-5cfaA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN
(Staphylococcus
aureus) 		3 / 3 ASN A 143
VAL A 123
HIS A  59
 None
 0.79A 6a5yD-5cfaA:
undetectable		 6a5yD-5cfaA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 5 GLN A 160
VAL A 179
PRO A 151
THR A 296
 None
 1.48A 6cduA-5cfaA:
3.5
6cduB-5cfaA:
3.4		 6cduA-5cfaA:
20.75
6cduB-5cfaA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN
(Staphylococcus
aureus) 		4 / 5 GLN A 160
VAL A 179
PRO A 151
THR A 296
 None
 1.46A 6cduI-5cfaA:
3.5
6cduJ-5cfaA:
3.2		 6cduI-5cfaA:
20.75
6cduJ-5cfaA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN
(Staphylococcus
aureus) 		5 / 12 LEU A 230
PHE A 264
VAL A 221
VAL A 191
TYR A 148
 None
 1.21A 6djzA-5cfaA:
undetectable		 6djzA-5cfaA:
21.57