SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cfe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AL4_B_DVAB6_0
(GRAMICIDIN D)		 5cfe EXODEOXYRIBONUCLEASE
(Bacillus
subtilis) 		4 / 5 TRP A   6
TRP A 201
ALA A 236
VAL A 246
 None
 1.26A 1al4A-5cfeA:
undetectable
1al4B-5cfeA:
undetectable		 1al4A-5cfeA:
5.67
1al4B-5cfeA:
5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ALZ_B_DVAB6_0
(ILE-GRAMICIDIN C
VAL-GRAMICIDIN A)		 5cfe EXODEOXYRIBONUCLEASE
(Bacillus
subtilis) 		4 / 5 TRP A   6
TRP A 201
ALA A 236
VAL A 246
 None
 1.22A 1alzA-5cfeA:
undetectable
1alzB-5cfeA:
undetectable		 1alzA-5cfeA:
4.48
1alzB-5cfeA:
5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5cfe EXODEOXYRIBONUCLEASE
(Bacillus
subtilis) 		4 / 7 ARG A 111
ALA A  58
ARG A  91
TYR A  63
 None
 1.20A 2e5dA-5cfeA:
undetectable
2e5dB-5cfeA:
undetectable		 2e5dA-5cfeA:
18.00
2e5dB-5cfeA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5cfe EXODEOXYRIBONUCLEASE
(Bacillus
subtilis) 		4 / 7 GLY A  82
THR A  94
ILE A  78
GLY A  80
 PEG  A 303 (-3.5A)
None
PEG  A 303 (-4.2A)
None
 0.88A 2jklC-5cfeA:
undetectable		 2jklC-5cfeA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5cfe EXODEOXYRIBONUCLEASE
(Bacillus
subtilis) 		3 / 3 TRP A 201
VAL A  14
ARG A  12
 None
 0.95A 3b0wA-5cfeA:
undetectable		 3b0wA-5cfeA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5cfe EXODEOXYRIBONUCLEASE
(Bacillus
subtilis) 		4 / 7 PRO A 139
VAL A 102
LEU A   3
ILE A 252
 None
 0.85A 3u5kB-5cfeA:
undetectable		 3u5kB-5cfeA:
17.86