SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cfk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 5cfk PROLIFERATING CELL
NUCLEAR
ANTIGEN,PROLIFERATIN
G CELL NUCLEAR
ANTIGEN
(Leishmania
donovani) 		5 / 10 LEU A  75
VAL A  78
GLU A   3
LEU A  90
VAL A  99
 None
 1.21A 1cqpA-5cfkA:
undetectable
1cqpB-5cfkA:
undetectable		 1cqpA-5cfkA:
20.99
1cqpB-5cfkA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 5cfk PROLIFERATING CELL
NUCLEAR
ANTIGEN,PROLIFERATIN
G CELL NUCLEAR
ANTIGEN
(Leishmania
donovani) 		4 / 8 TYR A  60
ASN A  31
LEU A  52
LEU A  51
 None
 1.04A 1e7cA-5cfkA:
undetectable		 1e7cA-5cfkA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 5cfk PROLIFERATING CELL
NUCLEAR
ANTIGEN,PROLIFERATIN
G CELL NUCLEAR
ANTIGEN
(Leishmania
donovani) 		5 / 12 LEU A  72
LEU A  70
ASN A  71
LEU A 118
LEU A  79
 None
 1.40A 1sqnA-5cfkA:
undetectable		 1sqnA-5cfkA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 5cfk PROLIFERATING CELL
NUCLEAR
ANTIGEN,PROLIFERATIN
G CELL NUCLEAR
ANTIGEN
(Leishmania
donovani) 		5 / 12 ILE A 241
LEU A  11
ILE A  19
TYR A 249
THR A 220
 None
 1.11A 2w3vA-5cfkA:
undetectable		 2w3vA-5cfkA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 5cfk PROLIFERATING CELL
NUCLEAR
ANTIGEN,PROLIFERATIN
G CELL NUCLEAR
ANTIGEN
(Leishmania
donovani) 		5 / 12 LEU A  72
LEU A  70
ASN A  71
LEU A 118
LEU A  79
 None
 1.40A 3d90A-5cfkA:
undetectable		 3d90A-5cfkA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 5cfk PROLIFERATING CELL
NUCLEAR
ANTIGEN,PROLIFERATIN
G CELL NUCLEAR
ANTIGEN
(Leishmania
donovani) 		4 / 6 LEU A 119
GLU A  25
ASN A  24
PHE A  28
 None
 1.38A 3i9jB-5cfkA:
undetectable		 3i9jB-5cfkA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 5cfk PROLIFERATING CELL
NUCLEAR
ANTIGEN,PROLIFERATIN
G CELL NUCLEAR
ANTIGEN
(Leishmania
donovani) 		3 / 3 THR A 102
SER A  89
ARG A  91
 None
 0.82A 3phnA-5cfkA:
undetectable		 3phnA-5cfkA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 5cfk PROLIFERATING CELL
NUCLEAR
ANTIGEN,PROLIFERATIN
G CELL NUCLEAR
ANTIGEN
(Leishmania
donovani) 		5 / 9 ALA A 216
VAL A 237
PHE A 215
LYS A 168
LEU A 227
 None
 1.25A 3ti1A-5cfkA:
undetectable		 3ti1A-5cfkA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 5cfk PROLIFERATING CELL
NUCLEAR
ANTIGEN,PROLIFERATIN
G CELL NUCLEAR
ANTIGEN
(Leishmania
donovani) 		4 / 5 ILE A 128
PRO A 129
SER A 125
GLY A 127
 None
 1.06A 3tkdB-5cfkA:
undetectable		 3tkdB-5cfkA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 5cfk PROLIFERATING CELL
NUCLEAR
ANTIGEN,PROLIFERATIN
G CELL NUCLEAR
ANTIGEN
(Leishmania
donovani) 		4 / 5 ILE A 128
PRO A 129
SER A 125
GLY A 127
 None
 1.09A 3tkdA-5cfkA:
undetectable		 3tkdA-5cfkA:
23.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 5cfk PROLIFERATING CELL
NUCLEAR
ANTIGEN,PROLIFERATIN
G CELL NUCLEAR
ANTIGEN
(Leishmania
donovani) 		4 / 6 MET A  40
LEU A  47
PRO A 234
TYR A 250
 None
 0.57A 3vkxA-5cfkA:
34.0		 3vkxA-5cfkA:
43.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5cfk PROLIFERATING CELL
NUCLEAR
ANTIGEN,PROLIFERATIN
G CELL NUCLEAR
ANTIGEN
(Leishmania
donovani) 		3 / 3 TYR A 246
HIS A  49
ARG A 248
 None
 0.88A 4e7bC-5cfkA:
undetectable		 4e7bC-5cfkA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 5cfk PROLIFERATING CELL
NUCLEAR
ANTIGEN,PROLIFERATIN
G CELL NUCLEAR
ANTIGEN
(Leishmania
donovani) 		3 / 3 PHE A 144
TYR A 249
TYR A 239
 None
 0.87A 4ffwA-5cfkA:
undetectable		 4ffwA-5cfkA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 5cfk PROLIFERATING CELL
NUCLEAR
ANTIGEN,PROLIFERATIN
G CELL NUCLEAR
ANTIGEN
(Leishmania
donovani) 		5 / 12 ILE A  19
ALA A  26
VAL A   6
LEU A  15
LEU A  79
 None
 1.39A 4qzuA-5cfkA:
2.6		 4qzuA-5cfkA:
18.92