SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cg9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5cg9 TET-LIKE DIOXYGENASE
(Naegleria
gruberi) 		5 / 12 HIS A 229
ASP A 231
LEU A 253
HIS A 279
VAL A 293
 MN  A 403 ( 3.3A)
MN  A 403 ( 2.5A)
AKG  A 402 (-3.7A)
MN  A 403 ( 3.4A)
AKG  A 402 (-4.8A)
 0.65A 1uobA-5cg9A:
8.1		 1uobA-5cg9A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5cg9 TET-LIKE DIOXYGENASE
(Naegleria
gruberi) 		5 / 11 HIS A 229
ASP A 231
HIS A 279
VAL A 281
VAL A 293
 MN  A 403 ( 3.3A)
MN  A 403 ( 2.5A)
MN  A 403 ( 3.4A)
AKG  A 402 (-4.9A)
AKG  A 402 (-4.8A)
 0.59A 1uofA-5cg9A:
6.3		 1uofA-5cg9A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5cg9 TET-LIKE DIOXYGENASE
(Naegleria
gruberi) 		3 / 3 LEU A 314
HIS A 317
LYS A 318
 None
 1.06A 1y7iA-5cg9A:
undetectable		 1y7iA-5cg9A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 5cg9 TET-LIKE DIOXYGENASE
(Naegleria
gruberi) 		3 / 3 TRP A  90
LEU A  85
LYS A  59
 None
 1.39A 1yajK-5cg9A:
undetectable		 1yajK-5cg9A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 5cg9 TET-LIKE DIOXYGENASE
(Naegleria
gruberi) 		4 / 4 LEU A 196
PRO A 209
LEU A 193
ARG A 188
 None
 1.48A 2qd2A-5cg9A:
undetectable		 2qd2A-5cg9A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 5cg9 TET-LIKE DIOXYGENASE
(Naegleria
gruberi) 		4 / 6 VAL A 293
ASP A 234
HIS A 297
ASN A 214
 AKG  A 402 (-4.8A)
None
None
AKG  A 402 (-3.5A)
 1.28A 2zs9A-5cg9A:
undetectable		 2zs9A-5cg9A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5cg9 TET-LIKE DIOXYGENASE
(Naegleria
gruberi) 		5 / 12 LEU A 292
GLY A 291
PHE A 241
PHE A 124
THR A 125
 None
 0.96A 3dh0A-5cg9A:
undetectable		 3dh0A-5cg9A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 5cg9 TET-LIKE DIOXYGENASE
(Naegleria
gruberi) 		4 / 5 THR A 211
GLY A 143
PRO A 209
ASN A 204
 None
 1.29A 3u8qA-5cg9A:
undetectable		 3u8qA-5cg9A:
22.77