SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cgl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 5cgl ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE NMFIC
(Neisseria
meningitidis) 		4 / 6 ARG A  24
LEU A  53
PHE A  50
ALA A  57
 None
 0.77A 1ukbA-5cglA:
undetectable		 1ukbA-5cglA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 5cgl ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE NMFIC
(Neisseria
meningitidis) 		6 / 12 LEU A  49
GLY A 114
GLY A 112
ILE A 179
SER A  18
LEU A  19
 None
PEG  A 201 (-3.4A)
PEG  A 201 (-3.1A)
None
None
None
 1.40A 1v2xA-5cglA:
undetectable		 1v2xA-5cglA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 5cgl ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE NMFIC
(Neisseria
meningitidis) 		5 / 7 GLU A  86
GLY A  41
GLN A  43
PHE A 109
ILE A  60
 None
 1.14A 2qmzA-5cglA:
undetectable
2qmzB-5cglA:
undetectable		 2qmzA-5cglA:
17.30
2qmzB-5cglA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 5cgl ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE NMFIC
(Neisseria
meningitidis) 		4 / 8 ALA A  40
GLY A  41
THR A  38
GLN A  44
 None
 0.89A 3rglA-5cglA:
undetectable		 3rglA-5cglA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD506_1
(HEMOLYTIC LECTIN
CEL-III)		 5cgl ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE NMFIC
(Neisseria
meningitidis) 		4 / 5 ASP A  15
GLU A 186
GLY A 187
TYR A 188
 None
PEG  A 201 (-3.9A)
None
None
 1.50A 3w9tD-5cglA:
undetectable		 3w9tD-5cglA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG505_1
(HEMOLYTIC LECTIN
CEL-III)		 5cgl ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE NMFIC
(Neisseria
meningitidis) 		4 / 5 ASP A  15
GLU A 186
GLY A 187
TYR A 188
 None
PEG  A 201 (-3.9A)
None
None
 1.41A 3w9tG-5cglA:
undetectable		 3w9tG-5cglA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 5cgl ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE NMFIC
(Neisseria
meningitidis) 		4 / 6 LEU A  82
LEU A  42
MET A  88
VAL A 124
 None
 1.11A 4okbA-5cglA:
undetectable		 4okbA-5cglA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 5cgl ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE NMFIC
(Neisseria
meningitidis) 		3 / 3 PHE A  93
THR A 117
LEU A 157
 None
 0.73A 4qztA-5cglA:
undetectable		 4qztA-5cglA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5cgl ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE NMFIC
(Neisseria
meningitidis) 		4 / 4 LEU A  25
ARG A 172
ILE A  31
PHE A  26
 None
 1.23A 5kirB-5cglA:
undetectable		 5kirB-5cglA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 5cgl ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE NMFIC
(Neisseria
meningitidis) 		5 / 5 TYR A  48
ILE A  45
LEU A  53
GLY A  51
PHE A  50
 None
 1.48A 5kmdC-5cglA:
undetectable
5kmdD-5cglA:
undetectable		 5kmdC-5cglA:
19.65
5kmdD-5cglA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5cgl ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE NMFIC
(Neisseria
meningitidis) 		4 / 6 TRP A 135
SER A 182
GLU A 186
TYR A 185
 None
None
PEG  A 201 (-3.9A)
None
 1.46A 5x7pA-5cglA:
undetectable		 5x7pA-5cglA:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5cgl ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE NMFIC
(Neisseria
meningitidis) 		4 / 6 TRP A 135
SER A 182
GLU A 186
TYR A 185
 None
None
PEG  A 201 (-3.9A)
None
 1.46A 5x7pB-5cglA:
undetectable		 5x7pB-5cglA:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5cgl ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE NMFIC
(Neisseria
meningitidis) 		4 / 6 TRP A 135
SER A 182
GLU A 186
TYR A 185
 None
None
PEG  A 201 (-3.9A)
None
 1.47A 5x7qA-5cglA:
undetectable		 5x7qA-5cglA:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5cgl ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE NMFIC
(Neisseria
meningitidis) 		4 / 6 TRP A 135
SER A 182
GLU A 186
TYR A 185
 None
None
PEG  A 201 (-3.9A)
None
 1.44A 5x7qB-5cglA:
undetectable		 5x7qB-5cglA:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5cgl ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE NMFIC
(Neisseria
meningitidis) 		4 / 6 TRP A 135
SER A 182
GLU A 186
TYR A 185
 None
None
PEG  A 201 (-3.9A)
None
 1.48A 5x7rA-5cglA:
undetectable		 5x7rA-5cglA:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5cgl ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE NMFIC
(Neisseria
meningitidis) 		4 / 6 TRP A 135
SER A 182
GLU A 186
TYR A 185
 None
None
PEG  A 201 (-3.9A)
None
 1.47A 5x7rB-5cglA:
undetectable		 5x7rB-5cglA:
9.54