SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cgz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 5cgz 4-OXALMESACONATE
HYDRATASE
(Pseudomonas
putida) 		4 / 5 ASP A  17
HIS A  14
HIS A 117
HIS A 127
 ZN  A 301 (-2.2A)
ZN  A 301 (-3.1A)
None
ZN  A 301 (-3.4A)
 1.09A 1ei6A-5cgzA:
undetectable		 1ei6A-5cgzA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5cgz 4-OXALMESACONATE
HYDRATASE
(Pseudomonas
putida) 		4 / 8 PHE A 161
GLY A  23
LEU A  78
VAL A  82
 None
 1.05A 1gsfA-5cgzA:
undetectable		 1gsfA-5cgzA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5cgz 4-OXALMESACONATE
HYDRATASE
(Pseudomonas
putida) 		4 / 8 PHE A 161
GLY A  23
LEU A  78
VAL A  82
 None
 1.05A 1gsfB-5cgzA:
undetectable		 1gsfB-5cgzA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5cgz 4-OXALMESACONATE
HYDRATASE
(Pseudomonas
putida) 		4 / 8 PHE A 161
GLY A  23
LEU A  78
VAL A  82
 None
 1.05A 1gsfD-5cgzA:
undetectable		 1gsfD-5cgzA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 5cgz 4-OXALMESACONATE
HYDRATASE
(Pseudomonas
putida) 		5 / 12 TYR A 106
LEU A  99
LEU A  41
MET A 131
ILE A 139
 None
 1.26A 1tw4B-5cgzA:
undetectable		 1tw4B-5cgzA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5cgz 4-OXALMESACONATE
HYDRATASE
(Pseudomonas
putida) 		3 / 3 ASP A  86
ASP A  89
ASP A  65
 GOL  A 308 (-3.3A)
None
None
 0.65A 2igtA-5cgzA:
3.4		 2igtA-5cgzA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 5cgz 4-OXALMESACONATE
HYDRATASE
(Pseudomonas
putida) 		4 / 6 ASP A  17
LEU A  41
LEU A 119
HIS A 132
 ZN  A 301 (-2.2A)
None
None
None
 1.25A 3bj8C-5cgzA:
undetectable
3bj8D-5cgzA:
undetectable		 3bj8C-5cgzA:
18.60
3bj8D-5cgzA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5cgz 4-OXALMESACONATE
HYDRATASE
(Pseudomonas
putida) 		3 / 3 ARG A  46
ASP A  86
ASP A  89
 None
GOL  A 308 (-3.3A)
None
 0.88A 3jayA-5cgzA:
2.7		 3jayA-5cgzA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5cgz 4-OXALMESACONATE
HYDRATASE
(Pseudomonas
putida) 		3 / 3 ARG A  46
ASP A  86
ASP A  89
 None
GOL  A 308 (-3.3A)
None
 0.83A 3jb2A-5cgzA:
2.4		 3jb2A-5cgzA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5cgz 4-OXALMESACONATE
HYDRATASE
(Pseudomonas
putida) 		3 / 3 ARG A  46
ASP A  86
ASP A  89
 None
GOL  A 308 (-3.3A)
None
 0.90A 3jb3A-5cgzA:
undetectable		 3jb3A-5cgzA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5cgz 4-OXALMESACONATE
HYDRATASE
(Pseudomonas
putida) 		3 / 3 TYR A 203
ASP A  17
ASP A  89
 None
ZN  A 301 (-2.2A)
None
 0.93A 3ou6B-5cgzA:
2.7		 3ou6B-5cgzA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 5cgz 4-OXALMESACONATE
HYDRATASE
(Pseudomonas
putida) 		5 / 12 PHE A 161
HIS A 127
HIS A 117
ALA A  22
PHE A  18
 None
ZN  A 301 (-3.4A)
None
None
None
 1.29A 3r2jC-5cgzA:
3.5		 3r2jC-5cgzA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 5cgz 4-OXALMESACONATE
HYDRATASE
(Pseudomonas
putida) 		4 / 8 ASP A  17
ALA A  13
SER A  42
TYR A  90
 ZN  A 301 (-2.2A)
ZN  A 301 ( 4.7A)
None
None
 0.97A 3rodA-5cgzA:
3.0		 3rodA-5cgzA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 5cgz 4-OXALMESACONATE
HYDRATASE
(Pseudomonas
putida) 		4 / 8 LEU A 115
MET A  36
TYR A  34
HIS A  29
 None
None
GOL  A 309 (-4.2A)
None
 1.36A 3zmdA-5cgzA:
undetectable
3zmdB-5cgzA:
undetectable		 3zmdA-5cgzA:
24.05
3zmdB-5cgzA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5cgz 4-OXALMESACONATE
HYDRATASE
(Pseudomonas
putida) 		4 / 8 LEU A 115
LEU A 177
ILE A 190
TRP A  20
 None
 1.06A 5ljbA-5cgzA:
undetectable		 5ljbA-5cgzA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 5cgz 4-OXALMESACONATE
HYDRATASE
(Pseudomonas
putida) 		5 / 10 LEU A   9
LEU A  99
LEU A 129
ALA A 130
LEU A  41
 None
 1.16A 5y7pB-5cgzA:
undetectable		 5y7pB-5cgzA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 5cgz 4-OXALMESACONATE
HYDRATASE
(Pseudomonas
putida) 		5 / 10 LEU A   9
LEU A  99
LEU A 129
ALA A 130
LEU A  41
 None
 1.18A 5y7pD-5cgzA:
undetectable		 5y7pD-5cgzA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 5cgz 4-OXALMESACONATE
HYDRATASE
(Pseudomonas
putida) 		5 / 10 LEU A   9
LEU A  99
LEU A 129
ALA A 130
LEU A  41
 None
 1.17A 5y7pH-5cgzA:
undetectable		 5y7pH-5cgzA:
21.19