SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ch8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 5ch8 MONO- AND
DIACYLGLYCEROL
LIPASE
(Penicillium
cyclopium) 		3 / 3 TRP A 116
ARG A 175
THR A 156
 None
 0.97A 1df7A-5ch8A:
undetectable		 1df7A-5ch8A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 5ch8 MONO- AND
DIACYLGLYCEROL
LIPASE
(Penicillium
cyclopium) 		5 / 10 ALA A 149
PHE A  80
ALA A 154
LEU A 158
LEU A  78
 None
 1.00A 2bxqA-5ch8A:
undetectable		 2bxqA-5ch8A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 5ch8 MONO- AND
DIACYLGLYCEROL
LIPASE
(Penicillium
cyclopium) 		4 / 6 SER A  20
SER A 145
LEU A 146
GLY A 147
 None
CL  A 304 (-3.6A)
GOL  A 308 (-3.6A)
None
 0.98A 2j2pA-5ch8A:
undetectable
2j2pC-5ch8A:
undetectable		 2j2pA-5ch8A:
21.52
2j2pC-5ch8A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 5ch8 MONO- AND
DIACYLGLYCEROL
LIPASE
(Penicillium
cyclopium) 		4 / 6 SER A  20
SER A 145
LEU A 146
GLY A 147
 None
CL  A 304 (-3.6A)
GOL  A 308 (-3.6A)
None
 1.00A 2j2pD-5ch8A:
undetectable
2j2pF-5ch8A:
undetectable		 2j2pD-5ch8A:
21.52
2j2pF-5ch8A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 5ch8 MONO- AND
DIACYLGLYCEROL
LIPASE
(Penicillium
cyclopium) 		4 / 9 ILE A 185
ARG A 193
ALA A 149
VAL A 176
 None
 1.03A 2vufB-5ch8A:
undetectable		 2vufB-5ch8A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 5ch8 MONO- AND
DIACYLGLYCEROL
LIPASE
(Penicillium
cyclopium) 		4 / 5 ASN A  40
ALA A 268
GLY A 269
TYR A  21
 None
None
None
CL  A 304 (-4.7A)
 1.17A 3bcrA-5ch8A:
undetectable		 3bcrA-5ch8A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5ch8 MONO- AND
DIACYLGLYCEROL
LIPASE
(Penicillium
cyclopium) 		4 / 6 ASN A  40
ALA A 268
GLY A 269
TYR A  21
 None
None
None
CL  A 304 (-4.7A)
 1.15A 3ddsA-5ch8A:
undetectable		 3ddsA-5ch8A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 5ch8 MONO- AND
DIACYLGLYCEROL
LIPASE
(Penicillium
cyclopium) 		5 / 12 HIS A 144
ASP A  62
PHE A 112
SER A  85
GLU A 109
 None
None
GOL  A 308 (-4.7A)
None
None
 1.29A 3tkaA-5ch8A:
undetectable		 3tkaA-5ch8A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 5ch8 MONO- AND
DIACYLGLYCEROL
LIPASE
(Penicillium
cyclopium) 		4 / 5 ASP A   8
THR A   4
LEU A   7
GLU A  11
 ZN  A 302 (-4.6A)
None
None
None
 1.22A 4a3pA-5ch8A:
undetectable		 4a3pA-5ch8A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5ch8 MONO- AND
DIACYLGLYCEROL
LIPASE
(Penicillium
cyclopium) 		5 / 12 TYR A 169
ALA A 170
ARG A 159
ALA A 154
LEU A  78
 None
 0.94A 4oaeA-5ch8A:
1.9		 4oaeA-5ch8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 5ch8 MONO- AND
DIACYLGLYCEROL
LIPASE
(Penicillium
cyclopium) 		3 / 3 THR A  72
ASN A  73
SER A  74
 None
CL  A 303 (-3.1A)
None
 0.71A 4tvtA-5ch8A:
undetectable		 4tvtA-5ch8A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5ch8 MONO- AND
DIACYLGLYCEROL
LIPASE
(Penicillium
cyclopium) 		4 / 5 ALA A  93
HIS A 196
PRO A 174
PHE A 256
 None
CL  A 305 ( 4.6A)
None
None
 1.42A 4ze2A-5ch8A:
undetectable		 4ze2A-5ch8A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 5ch8 MONO- AND
DIACYLGLYCEROL
LIPASE
(Penicillium
cyclopium) 		3 / 3 THR A 197
ALA A 258
ASN A 198
 CL  A 305 (-2.9A)
CL  A 305 ( 3.9A)
CL  A 305 ( 4.6A)
 0.52A 5ersA-5ch8A:
undetectable		 5ersA-5ch8A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5ch8 MONO- AND
DIACYLGLYCEROL
LIPASE
(Penicillium
cyclopium) 		5 / 12 THR A  61
PHE A  80
GLY A  82
SER A  83
SER A  20
 CL  A 306 (-4.7A)
None
GOL  A 308 (-3.5A)
GOL  A 308 (-4.7A)
None
 1.32A 5hfjB-5ch8A:
undetectable		 5hfjB-5ch8A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5ch8 MONO- AND
DIACYLGLYCEROL
LIPASE
(Penicillium
cyclopium) 		5 / 12 TYR A  21
ALA A 151
LEU A 153
ALA A  79
GLY A 143
 CL  A 304 (-4.7A)
None
None
None
None
 1.41A 5jglB-5ch8A:
undetectable		 5jglB-5ch8A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5ch8 MONO- AND
DIACYLGLYCEROL
LIPASE
(Penicillium
cyclopium) 		4 / 5 LEU A 110
ALA A 108
LEU A 107
LEU A 153
 None
 0.83A 5vkqA-5ch8A:
undetectable
5vkqD-5ch8A:
undetectable		 5vkqA-5ch8A:
10.55
5vkqD-5ch8A:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5ch8 MONO- AND
DIACYLGLYCEROL
LIPASE
(Penicillium
cyclopium) 		4 / 5 LEU A 153
LEU A 110
ALA A 108
LEU A 107
 None
 0.83A 5vkqA-5ch8A:
undetectable
5vkqB-5ch8A:
undetectable		 5vkqA-5ch8A:
10.55
5vkqB-5ch8A:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5ch8 MONO- AND
DIACYLGLYCEROL
LIPASE
(Penicillium
cyclopium) 		4 / 5 LEU A 153
LEU A 110
ALA A 108
LEU A 107
 None
 0.82A 5vkqB-5ch8A:
undetectable
5vkqC-5ch8A:
undetectable		 5vkqB-5ch8A:
10.55
5vkqC-5ch8A:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5ch8 MONO- AND
DIACYLGLYCEROL
LIPASE
(Penicillium
cyclopium) 		4 / 5 LEU A 153
LEU A 110
ALA A 108
LEU A 107
 None
 0.85A 5vkqC-5ch8A:
undetectable
5vkqD-5ch8A:
undetectable		 5vkqC-5ch8A:
10.55
5vkqD-5ch8A:
10.55