SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5chc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 8 GLY A 248
THR A 424
GLY A 251
LEU A 434
 MGD  A1003 (-3.8A)
MGD  A1003 ( 4.9A)
None
None
 0.81A 1aegA-5chcA:
undetectable		 1aegA-5chcA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		5 / 12 ALA A 113
LEU A 579
PHE A 153
LEU A 652
ALA A 118
 None
 1.10A 1bzfA-5chcA:
3.2		 1bzfA-5chcA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		6 / 12 ALA A 411
ILE A 403
PRO A 389
LEU A 253
TYR A 196
THR A 444
 None
 1.44A 1dhfA-5chcA:
undetectable		 1dhfA-5chcA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 8 SER A 134
VAL A 532
ALA A 159
PHE A 153
 None
 1.08A 1dmiA-5chcA:
undetectable
1dmiB-5chcA:
undetectable		 1dmiA-5chcA:
19.91
1dmiB-5chcA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 7 CYH A 186
ASP A 190
GLY A 452
GLY A 453
 None
 0.93A 1ekjE-5chcA:
undetectable
1ekjF-5chcA:
undetectable		 1ekjE-5chcA:
13.71
1ekjF-5chcA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 6 GLY A 248
ASP A 250
GLY A 201
SER A 430
 MGD  A1003 (-3.8A)
MGD  A1003 (-2.8A)
MGD  A1003 (-3.4A)
None
 0.91A 1eswA-5chcA:
undetectable		 1eswA-5chcA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		5 / 12 PHE A 534
LEU A 649
PHE A 638
GLY A 158
GLY A 150
 None
 0.91A 1fe2A-5chcA:
undetectable		 1fe2A-5chcA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 6 ILE A 672
GLU A 666
LEU A 588
ASP A 589
 None
 0.91A 1mt1B-5chcA:
undetectable
1mt1C-5chcA:
undetectable		 1mt1B-5chcA:
10.70
1mt1C-5chcA:
4.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		5 / 12 LEU A  33
VAL A 142
SER A 143
SER A 581
HIS A 770
 MD1  A1004 (-4.6A)
None
None
MD1  A1004 (-3.4A)
MD1  A1004 ( 3.5A)
 1.29A 1rk3A-5chcA:
undetectable		 1rk3A-5chcA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 7 LEU A 620
GLU A 664
LEU A 472
ALA A 149
 None
 1.16A 1sn0B-5chcA:
undetectable
1sn0D-5chcA:
undetectable		 1sn0B-5chcA:
9.79
1sn0D-5chcA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		5 / 10 ALA A 411
ILE A 403
LEU A 253
TYR A 196
THR A 444
 None
 1.41A 1tdrB-5chcA:
undetectable		 1tdrB-5chcA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		5 / 12 SER A 148
ALA A 471
GLY A 468
LEU A 469
PHE A 465
 None
 1.30A 1vpoH-5chcA:
undetectable
1vpoL-5chcA:
undetectable		 1vpoH-5chcA:
12.54
1vpoL-5chcA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 7 ALA A 753
ILE A 501
ILE A 505
ASP A 504
 None
 0.99A 1yc5A-5chcA:
3.8		 1yc5A-5chcA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		5 / 12 PHE A 410
ALA A 223
ILE A 198
ILE A 418
LEU A 215
 None
EDO  A1007 ( 3.7A)
None
None
None
 1.33A 2bjfA-5chcA:
undetectable		 2bjfA-5chcA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		5 / 12 SER A 575
LEU A 622
ALA A 154
ILE A 157
ILE A 133
 None
 0.88A 2bxcA-5chcA:
undetectable		 2bxcA-5chcA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 5 ALA A 753
ILE A 501
ILE A 505
ASP A 504
 None
 1.02A 2h4jA-5chcA:
2.1		 2h4jA-5chcA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 7 ASN A 455
GLY A 453
THR A 449
MET A 417
 None
 1.19A 2o5yH-5chcA:
undetectable
2o5yL-5chcA:
undetectable		 2o5yH-5chcA:
12.85
2o5yL-5chcA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		3 / 3 SER A 146
HIS A  32
ASP A  82
 MD1  A1004 ( 4.7A)
SF4  A1001 (-3.3A)
NA  A1015 ( 4.9A)
 0.81A 2oxtA-5chcA:
undetectable		 2oxtA-5chcA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 7 TYR A 457
TRP A 191
GLN A 425
ILE A 197
 None
 1.34A 2ph9A-5chcA:
undetectable
2ph9B-5chcA:
undetectable		 2ph9A-5chcA:
13.11
2ph9B-5chcA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		3 / 3 LEU A 579
PRO A 580
ARG A 625
 None
 0.42A 2qd5A-5chcA:
undetectable		 2qd5A-5chcA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		3 / 3 GLN A 460
THR A 772
TRP A 584
 None
MD1  A1004 (-3.8A)
MD1  A1004 (-4.2A)
 1.12A 2rctA-5chcA:
undetectable		 2rctA-5chcA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		3 / 3 PRO A 172
GLY A 183
TYR A 165
 None
 0.70A 2vouA-5chcA:
undetectable		 2vouA-5chcA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		3 / 3 PRO A 172
GLY A 183
TYR A 165
 None
 0.68A 2vouB-5chcA:
undetectable		 2vouB-5chcA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		3 / 3 PRO A 172
GLY A 183
TYR A 165
 None
 0.66A 2vouC-5chcA:
undetectable		 2vouC-5chcA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		6 / 12 ALA A 411
ILE A 403
PRO A 389
LEU A 253
TYR A 196
THR A 444
 None
 1.44A 2w3bA-5chcA:
undetectable		 2w3bA-5chcA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_1
(HYPOTHETICAL PROTEIN)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 4 GLY A 448
GLU A 447
ASP A 184
TYR A 708
 None
None
None
EDO  A1006 (-4.2A)
 1.30A 2yvlC-5chcA:
1.8		 2yvlC-5chcA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 5 LEU A 554
GLN A 547
THR A 486
HIS A 162
 None
 1.16A 2zj0B-5chcA:
3.1		 2zj0B-5chcA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 7 SER A 575
SER A 570
GLU A 838
ASP A 775
 None
 0.86A 3bc9A-5chcA:
undetectable		 3bc9A-5chcA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		5 / 12 LEU A 511
ASN A 522
VAL A 496
THR A 487
ILE A 856
 None
 1.23A 3bf1A-5chcA:
undetectable
3bf1B-5chcA:
undetectable		 3bf1A-5chcA:
16.22
3bf1B-5chcA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_1
(PHOSPHOLIPASE A2)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 4 SER A 143
PRO A 144
PHE A 147
PRO A 140
 None
 1.40A 3bjwA-5chcA:
undetectable		 3bjwA-5chcA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_1
(PHOSPHOLIPASE A2)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 4 SER A 143
PRO A 144
PHE A 147
PRO A 140
 None
 1.43A 3bjwD-5chcA:
0.0		 3bjwD-5chcA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 5 LEU A 554
GLN A 547
THR A 486
HIS A 162
 None
 1.28A 3ce6B-5chcA:
undetectable		 3ce6B-5chcA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		5 / 12 ILE A 117
PHE A 619
LEU A 622
ALA A 621
VAL A 532
 None
 1.12A 3dzyA-5chcA:
undetectable		 3dzyA-5chcA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 4 ILE A 505
ARG A 759
ILE A 500
THR A 859
 None
 1.26A 3ia4C-5chcA:
undetectable		 3ia4C-5chcA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		5 / 10 TYR A 491
ASP A 498
LEU A 511
TYR A 428
ILE A 751
 None
 1.37A 3kz7A-5chcA:
undetectable		 3kz7A-5chcA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		5 / 10 ALA A 809
ILE A 817
GLY A 846
PRO A 787
ILE A 789
 None
 0.99A 3nujA-5chcA:
undetectable		 3nujA-5chcA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		5 / 9 ALA A 809
ILE A 817
GLY A 846
PRO A 787
ILE A 789
 None
 0.95A 3nuoA-5chcA:
undetectable		 3nuoA-5chcA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		5 / 12 ASP A 123
ILE A 125
VAL A 562
ILE A 564
ILE A 157
 None
None
None
MD1  A1004 (-4.4A)
None
 1.08A 3ohtA-5chcA:
undetectable
3ohtB-5chcA:
undetectable		 3ohtA-5chcA:
16.96
3ohtB-5chcA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		5 / 10 ALA A 809
ILE A 817
GLY A 846
PRO A 787
ILE A 789
 None
 1.05A 3oxvB-5chcA:
undetectable		 3oxvB-5chcA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		5 / 11 ALA A 809
ILE A 817
GLY A 846
PRO A 787
ILE A 789
 None
 1.04A 3oxvD-5chcA:
undetectable		 3oxvD-5chcA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 6 GLN A 485
MET A 520
ILE A 488
SER A 880
 None
 1.33A 3pmzD-5chcA:
undetectable		 3pmzD-5chcA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		5 / 12 GLY A 477
ALA A 154
ASP A 131
ASN A 479
PHE A 643
 None
 1.33A 3qowA-5chcA:
1.7		 3qowA-5chcA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 7 MET A 779
ARG A 784
GLY A 786
PRO A 787
 None
 1.30A 3ucbB-5chcA:
undetectable		 3ucbB-5chcA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 5 LEU A 662
ARG A 152
PRO A 475
ALA A 471
 None
 1.21A 3vm4A-5chcA:
undetectable		 3vm4A-5chcA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 8 THR A 178
TYR A 874
ARG A 435
LEU A 434
 None
 1.24A 3wipG-5chcA:
undetectable
3wipH-5chcA:
undetectable		 3wipG-5chcA:
12.36
3wipH-5chcA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9W_A_VGHA1158_1
(7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		5 / 12 LEU A 560
PHE A 534
PHE A 153
VAL A 532
PHE A 619
 None
 1.39A 4c9wA-5chcA:
undetectable		 4c9wA-5chcA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		6 / 12 ALA A 411
ILE A 403
PRO A 389
LEU A 253
TYR A 196
THR A 444
 None
 1.47A 4kfjB-5chcA:
undetectable		 4kfjB-5chcA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 8 HIS A 456
PRO A 172
SER A 700
PHE A 711
 None
 0.99A 4kttA-5chcA:
undetectable		 4kttA-5chcA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 8 HIS A 456
PRO A 172
SER A 700
PHE A 711
 None
 0.93A 4kttC-5chcA:
undetectable		 4kttC-5chcA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		6 / 12 ALA A 411
ILE A 403
PRO A 389
LEU A 253
TYR A 196
THR A 444
 None
 1.44A 4m6kA-5chcA:
undetectable		 4m6kA-5chcA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 7 HIS A 456
PRO A 172
SER A 700
PHE A 711
 None
 0.91A 4ndnC-5chcA:
undetectable		 4ndnC-5chcA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 7 HIS A 456
PRO A 172
SER A 700
PHE A 711
 None
 0.96A 4odjA-5chcA:
undetectable		 4odjA-5chcA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 6 PHE A 737
TYR A 865
LEU A 868
THR A 173
 None
 1.37A 4paeA-5chcA:
undetectable		 4paeA-5chcA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		5 / 12 ILE A 403
ALA A 407
VAL A 432
LEU A 379
LEU A 383
 None
 1.00A 4qzuC-5chcA:
undetectable		 4qzuC-5chcA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_1
(HIV-1 PROTEASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		5 / 11 ALA A 809
ILE A 817
GLY A 846
PRO A 787
ILE A 789
 None
 0.98A 4rvjC-5chcA:
undetectable		 4rvjC-5chcA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		5 / 11 ALA A 385
LEU A 383
GLU A 377
LEU A 379
LEU A 744
 None
 0.98A 4wg0E-5chcA:
undetectable
4wg0F-5chcA:
undetectable
4wg0G-5chcA:
undetectable		 4wg0E-5chcA:
1.68
4wg0F-5chcA:
1.68
4wg0G-5chcA:
1.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 6 SER A 765
GLY A  80
ASP A  82
GLY A  77
 None
None
NA  A1015 ( 4.9A)
SF4  A1001 ( 3.7A)
 0.95A 5cdnC-5chcA:
undetectable
5cdnD-5chcA:
1.9		 5cdnC-5chcA:
19.12
5cdnD-5chcA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 6 SER A 765
GLY A  80
ASP A  82
GLY A  77
 None
None
NA  A1015 ( 4.9A)
SF4  A1001 ( 3.7A)
 0.95A 5cdnT-5chcA:
undetectable
5cdnU-5chcA:
1.7		 5cdnT-5chcA:
19.12
5cdnU-5chcA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 6 SER A 765
GLY A  80
ASP A  82
GLY A  77
 None
None
NA  A1015 ( 4.9A)
SF4  A1001 ( 3.7A)
 0.87A 5cdpA-5chcA:
undetectable
5cdpB-5chcA:
undetectable		 5cdpA-5chcA:
19.18
5cdpB-5chcA:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		5 / 12 TYR A 875
GLY A 876
GLN A 485
ILE A 395
PHE A 737
 None
 1.24A 5fsaB-5chcA:
undetectable		 5fsaB-5chcA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 6 TYR A 549
ILE A 500
ARG A 855
TYR A 756
 None
 1.23A 5igyA-5chcA:
undetectable		 5igyA-5chcA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		5 / 12 ASP A 170
GLY A 459
ALA A  39
VAL A 769
ASN A 591
 MO  A1002 ( 2.6A)
BSY  A1013 ( 3.0A)
None
MGD  A1003 ( 4.1A)
None
 1.19A 5kbwB-5chcA:
undetectable		 5kbwB-5chcA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 8 GLN A  56
ASN A 600
ALA A  31
HIS A 596
 None
 1.05A 5km8A-5chcA:
undetectable
5km8B-5chcA:
undetectable		 5km8A-5chcA:
10.18
5km8B-5chcA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 5 ILE A 682
LEU A 469
GLY A 468
PHE A 465
 None
 0.96A 5kmdC-5chcA:
undetectable
5kmdD-5chcA:
undetectable		 5kmdC-5chcA:
15.65
5kmdD-5chcA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 5 PHE A 773
SER A 768
ASN A 565
ASP A 563
 None
MGD  A1003 (-4.6A)
MD1  A1004 (-2.9A)
None
 1.37A 5kpcA-5chcA:
undetectable		 5kpcA-5chcA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		5 / 9 ALA A 809
ILE A 817
GLY A 846
PRO A 787
ILE A 789
 None
 0.99A 5kr0A-5chcA:
undetectable		 5kr0A-5chcA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		3 / 3 THR A 249
PRO A 750
ASP A 752
 None
 0.92A 5l8dB-5chcA:
undetectable		 5l8dB-5chcA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		5 / 12 ALA A 669
LEU A 590
SER A 148
GLY A  30
ILE A 684
 None
 1.11A 5m24A-5chcA:
undetectable		 5m24A-5chcA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		3 / 3 THR A 249
PRO A 750
ASP A 752
 None
 0.92A 5mwuB-5chcA:
undetectable		 5mwuB-5chcA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		5 / 12 TRP A 461
PRO A 722
VAL A 332
GLY A 333
GLY A 336
 None
 1.11A 5nnaC-5chcA:
undetectable		 5nnaC-5chcA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		5 / 9 ALA A 436
ILE A 261
LEU A 443
ILE A 262
ASN A 387
 None
 0.98A 5nunA-5chcA:
undetectable		 5nunA-5chcA:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 6 ARG A 208
GLY A  38
GLU A 595
SER A 594
 MGD  A1003 ( 3.6A)
SF4  A1001 ( 3.8A)
None
None
 1.06A 5ny7A-5chcA:
undetectable		 5ny7A-5chcA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 8 PHE A 214
ARG A 208
THR A  37
GLY A  38
 None
MGD  A1003 ( 3.6A)
MGD  A1003 ( 4.8A)
SF4  A1001 ( 3.8A)
 1.00A 5nzxA-5chcA:
undetectable		 5nzxA-5chcA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 8 SER A 832
ARG A 830
GLN A 881
PHE A 760
 MGD  A1003 ( 4.9A)
MGD  A1003 (-3.1A)
MD1  A1004 (-3.1A)
None
 1.35A 5vunB-5chcA:
undetectable		 5vunB-5chcA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 7 LEU A 215
HIS A 764
ASP A 211
HIS A 426
 None
MGD  A1003 ( 3.5A)
None
MD1  A1004 (-4.4A)
 1.24A 5z85C-5chcA:
undetectable
5z85N-5chcA:
undetectable
5z85P-5chcA:
undetectable		 5z85C-5chcA:
14.30
5z85N-5chcA:
19.08
5z85P-5chcA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 4 LEU A 649
ASP A 648
GLN A 655
VAL A 577
 None
 1.15A 6bzoF-5chcA:
undetectable		 6bzoF-5chcA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		5 / 9 PHE A 360
VAL A 372
ILE A 316
ARG A 283
ASP A 294
 None
 1.15A 6c2mC-5chcA:
undetectable		 6c2mC-5chcA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		4 / 8 HIS A 456
PRO A 172
SER A 700
PHE A 711
 None
 0.93A 6fbnB-5chcA:
undetectable		 6fbnB-5chcA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		3 / 3 HIS A 770
HIS A 764
HIS A 835
 MD1  A1004 ( 3.5A)
MGD  A1003 ( 3.5A)
MD1  A1004 ( 4.4A)
 0.77A 6giqa-5chcA:
undetectable		 6giqa-5chcA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		3 / 3 ARG A 373
LYS A 287
TYR A 731
 None
 1.35A 6gnaA-5chcA:
2.0		 6gnaA-5chcA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT
(Azospira
oryzae) 		3 / 3 ARG A 373
LYS A 287
TYR A 731
 None
 1.35A 6gnbA-5chcA:
2.0		 6gnbA-5chcA:
14.95