SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5chl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5chl HISTONE H2A.Z
(Homo
sapiens) 		4 / 6 ARG B  55
ARG B 119
GLY B 121
ALA B 122
 None
 0.83A 1wmqA-5chlB:
undetectable		 1wmqA-5chlB:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5chl HISTONE H2A.Z
(Homo
sapiens) 		4 / 6 ARG B  55
ARG B 119
GLY B 121
ALA B 122
 None
 0.84A 1wmqB-5chlB:
undetectable		 1wmqB-5chlB:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5chl HISTONE H2A.Z
(Homo
sapiens) 		4 / 6 ARG B  55
ARG B 119
GLY B 121
ALA B 122
 None
 0.84A 1wpuA-5chlB:
undetectable		 1wpuA-5chlB:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5chl HISTONE H2A.Z
(Homo
sapiens) 		4 / 6 ARG B  55
ARG B 119
GLY B 121
ALA B 122
 None
 0.84A 1wpuB-5chlB:
1.8		 1wpuB-5chlB:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5chl HISTONE H2A.Z
(Homo
sapiens) 		4 / 6 ARG B  55
ARG B 119
GLY B 121
ALA B 122
 None
 0.82A 1wrqA-5chlB:
undetectable		 1wrqA-5chlB:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5chl HISTONE H2A.Z
(Homo
sapiens) 		4 / 6 ARG B  55
ARG B 119
GLY B 121
ALA B 122
 None
 0.84A 1wrqB-5chlB:
undetectable		 1wrqB-5chlB:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 5chl HISTONE H2A.Z
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 72 HOMOLOG
(Drosophila
melanogaster;
Homo
sapiens) 		4 / 6 ASP A  59
ILE A  62
GLU A  64
TYR B  90
 None
 1.19A 2ya7C-5chlA:
undetectable		 2ya7C-5chlA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 5chl HISTONE H2A.Z
(Homo
sapiens) 		5 / 12 LEU B 160
LEU B 162
ALA B 143
THR B  21
VAL B 152
 None
 1.22A 3cwkA-5chlB:
undetectable		 3cwkA-5chlB:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 5chl HISTONE H2A.Z
(Homo
sapiens) 		4 / 5 LEU B 173
ARG B  41
LEU B  71
PRO B  72
 None
 1.30A 3onnA-5chlB:
undetectable		 3onnA-5chlB:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 5chl HISTONE H2A.Z
(Homo
sapiens) 		3 / 3 THR B  59
SER B  60
ARG B  61
 None
 0.52A 3phnA-5chlB:
undetectable		 3phnA-5chlB:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 5chl HISTONE H2A.Z
(Homo
sapiens) 		4 / 5 ILE B  58
THR B 114
THR B 115
SER B 116
 None
 1.11A 3snfA-5chlB:
undetectable		 3snfA-5chlB:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 5chl VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 72 HOMOLOG
HISTONE H2A.Z
(Drosophila
melanogaster;
Homo
sapiens) 		3 / 3 PHE A  29
ASP A  27
ARG B 165
 None
 0.90A 4eahF-5chlA:
undetectable		 4eahF-5chlA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 5chl VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 72 HOMOLOG
HISTONE H2A.Z
(Drosophila
melanogaster;
Homo
sapiens) 		3 / 3 PHE A  29
ASP A  27
ARG B 165
 None
 0.90A 4eahG-5chlA:
undetectable		 4eahG-5chlA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5chl HISTONE H2A.Z
(Homo
sapiens) 		5 / 11 SER B 128
THR B  57
GLY B 121
ALA B 124
THR B 123
 None
 1.08A 4qvlV-5chlB:
undetectable
4qvlb-5chlB:
undetectable		 4qvlV-5chlB:
20.91
4qvlb-5chlB:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5chl HISTONE H2A.Z
(Homo
sapiens) 		5 / 11 SER B 128
THR B  57
GLY B 121
ALA B 124
THR B 123
 None
 1.08A 4qvlH-5chlB:
undetectable
4qvlN-5chlB:
undetectable		 4qvlH-5chlB:
20.91
4qvlN-5chlB:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5chl HISTONE H2A.Z
(Homo
sapiens) 		5 / 11 SER B 128
THR B  57
GLY B 121
ALA B 124
THR B 123
 None
 1.08A 4qvwV-5chlB:
undetectable
4qvwb-5chlB:
undetectable		 4qvwV-5chlB:
20.91
4qvwb-5chlB:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5chl HISTONE H2A.Z
(Homo
sapiens) 		5 / 11 SER B 128
THR B  57
GLY B 121
ALA B 124
THR B 123
 None
 1.08A 4qvwH-5chlB:
undetectable
4qvwN-5chlB:
undetectable		 4qvwH-5chlB:
20.91
4qvwN-5chlB:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5chl HISTONE H2A.Z
(Homo
sapiens) 		5 / 11 SER B 128
THR B  57
GLY B 121
ALA B 124
THR B 123
 None
 1.09A 4qw1V-5chlB:
undetectable
4qw1b-5chlB:
undetectable		 4qw1V-5chlB:
20.91
4qw1b-5chlB:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5chl HISTONE H2A.Z
(Homo
sapiens) 		5 / 11 SER B 128
THR B  57
GLY B 121
ALA B 124
THR B 123
 None
 1.09A 4qw1H-5chlB:
undetectable
4qw1N-5chlB:
undetectable		 4qw1H-5chlB:
20.91
4qw1N-5chlB:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5chl HISTONE H2A.Z
(Homo
sapiens) 		5 / 11 SER B 128
THR B  57
GLY B 121
ALA B 124
THR B 123
 None
 1.10A 4qwuV-5chlB:
undetectable
4qwub-5chlB:
undetectable		 4qwuV-5chlB:
20.91
4qwub-5chlB:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5chl HISTONE H2A.Z
(Homo
sapiens) 		5 / 11 SER B 128
THR B  57
GLY B 121
ALA B 124
THR B 123
 None
 1.11A 5bxnV-5chlB:
undetectable
5bxnb-5chlB:
undetectable		 5bxnV-5chlB:
23.69
5bxnb-5chlB:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5chl HISTONE H2A.Z
(Homo
sapiens) 		5 / 11 SER B 128
THR B  57
GLY B 121
ALA B 124
THR B 123
 None
 1.11A 5bxnH-5chlB:
undetectable
5bxnN-5chlB:
undetectable		 5bxnH-5chlB:
23.69
5bxnN-5chlB:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5chl HISTONE H2A.Z
(Homo
sapiens) 		4 / 6 THR B 123
ALA B 124
THR B  59
VAL B 120
 None
 1.02A 5ecoA-5chlB:
undetectable		 5ecoA-5chlB:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5chl HISTONE H2A.Z
(Homo
sapiens) 		5 / 11 SER B 128
THR B  57
GLY B 121
ALA B 124
THR B 123
 None
 1.11A 5l66V-5chlB:
undetectable
5l66b-5chlB:
undetectable		 5l66V-5chlB:
20.91
5l66b-5chlB:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5chl HISTONE H2A.Z
(Homo
sapiens) 		5 / 11 SER B 128
THR B  57
GLY B 121
ALA B 124
THR B 123
 None
 1.11A 5l66H-5chlB:
undetectable
5l66N-5chlB:
undetectable		 5l66H-5chlB:
20.91
5l66N-5chlB:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5chl HISTONE H2A.Z
(Homo
sapiens) 		5 / 12 ILE B 155
GLY B 144
VAL B  17
ILE B  30
ALA B  27
 None
 1.09A 5n0tA-5chlB:
undetectable		 5n0tA-5chlB:
18.54