SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cho'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 5cho FLAVIN REDUCTASE
(uncultured
bacterium) 		3 / 3 ALA A 154
VAL A 164
TRP A 152
 None
 0.86A 1kqeA-5choA:
undetectable
1kqeE-5choA:
undetectable		 1kqeA-5choA:
7.69
1kqeE-5choA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 5cho FLAVIN REDUCTASE
(uncultured
bacterium) 		3 / 3 ALA A 154
VAL A 164
TRP A 152
 None
 0.87A 1kqeB-5choA:
undetectable
1kqeD-5choA:
undetectable		 1kqeB-5choA:
7.69
1kqeD-5choA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 5cho FLAVIN REDUCTASE
(uncultured
bacterium) 		3 / 3 TRP A 152
ALA A 154
VAL A 164
 None
 0.88A 1kqeB-5choA:
undetectable
1kqeD-5choA:
undetectable		 1kqeB-5choA:
7.69
1kqeD-5choA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 5cho FLAVIN REDUCTASE
(uncultured
bacterium) 		3 / 3 TRP A 152
ALA A 154
VAL A 164
 None
 0.87A 1kqeA-5choA:
undetectable
1kqeE-5choA:
undetectable		 1kqeA-5choA:
7.69
1kqeE-5choA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_D_AZZD1211_1
(DEOXYNUCLEOSIDE
KINASE)		 5cho FLAVIN REDUCTASE
(uncultured
bacterium) 		5 / 10 ILE A 162
PHE A  96
VAL A  51
MET A  61
ALA A  63
 None
None
None
FAD  A 201 (-4.7A)
FAD  A 201 (-3.8A)
 1.46A 2jj8D-5choA:
undetectable		 2jj8D-5choA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5cho FLAVIN REDUCTASE
(uncultured
bacterium) 		5 / 12 VAL A  98
TRP A 129
PHE A 186
VAL A 100
THR A  52
 None
None
FAD  A 201 (-4.8A)
None
None
 1.43A 4kyaB-5choA:
undetectable		 4kyaB-5choA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5cho FLAVIN REDUCTASE
(uncultured
bacterium) 		5 / 12 VAL A  98
TRP A 129
PHE A 186
VAL A 100
THR A  52
 None
None
FAD  A 201 (-4.8A)
None
None
 1.42A 4kyaD-5choA:
undetectable		 4kyaD-5choA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5cho FLAVIN REDUCTASE
(uncultured
bacterium) 		5 / 12 VAL A  98
TRP A 129
PHE A 186
VAL A 100
THR A  52
 None
None
FAD  A 201 (-4.8A)
None
None
 1.42A 4kyaF-5choA:
undetectable		 4kyaF-5choA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5cho FLAVIN REDUCTASE
(uncultured
bacterium) 		5 / 12 VAL A  98
TRP A 129
PHE A 186
VAL A 100
THR A  52
 None
None
FAD  A 201 (-4.8A)
None
None
 1.45A 4kyaH-5choA:
undetectable		 4kyaH-5choA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5cho FLAVIN REDUCTASE
(uncultured
bacterium) 		5 / 12 GLY A 165
VAL A  78
ALA A  63
THR A  49
GLY A  97
 None
None
FAD  A 201 (-3.8A)
None
None
 0.87A 5hieB-5choA:
undetectable		 5hieB-5choA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5cho FLAVIN REDUCTASE
(uncultured
bacterium) 		5 / 12 GLY A 165
VAL A  78
ALA A  63
THR A  49
GLY A  97
 None
None
FAD  A 201 (-3.8A)
None
None
 0.85A 5hieD-5choA:
3.1		 5hieD-5choA:
19.48