SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5chs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)
5chs RNA-DIRECTED RNA
POLYMERASE L

(Indiana
vesiculovirus)
4 / 4 ILE A 238
MET A 233
VAL A 275
GLY A 240
None
1.17A 1e06B-5chsA:
undetectable
1e06B-5chsA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)
5chs RNA-DIRECTED RNA
POLYMERASE L

(Indiana
vesiculovirus)
5 / 12 LEU A 231
ILE A 212
THR A 210
ILE A  54
LEU A  53
None
1.18A 2jn3A-5chsA:
undetectable
2jn3A-5chsA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)
5chs RNA-DIRECTED RNA
POLYMERASE L

(Indiana
vesiculovirus)
4 / 6 ILE A 199
CYH A  81
PRO A  85
LEU A  53
None
0.99A 2q83B-5chsA:
2.1
2q83B-5chsA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
5chs RNA-DIRECTED RNA
POLYMERASE L

(Indiana
vesiculovirus)
5 / 12 PRO A 291
GLY A 271
ALA A 326
GLY A 325
ILE A 274
None
0.96A 3ku1A-5chsA:
undetectable
3ku1A-5chsA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)
5chs RNA-DIRECTED RNA
POLYMERASE L

(Indiana
vesiculovirus)
5 / 10 TYR A 218
ASP A 223
LEU A  78
LEU A  53
ILE A  50
None
1.07A 4odoB-5chsA:
undetectable
4odoB-5chsA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)
5chs RNA-DIRECTED RNA
POLYMERASE L

(Indiana
vesiculovirus)
5 / 12 GLY A 359
LEU A  99
MET A  95
MET A  91
ILE A 239
None
0.96A 4okbA-5chsA:
undetectable
4okbA-5chsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)
5chs RNA-DIRECTED RNA
POLYMERASE L

(Indiana
vesiculovirus)
5 / 9 LEU A 297
ILE A 351
LEU A 347
VAL A 345
THR A 348
None
1.16A 4x3mB-5chsA:
undetectable
4x3mB-5chsA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)
5chs RNA-DIRECTED RNA
POLYMERASE L

(Indiana
vesiculovirus)
5 / 10 ILE A 286
ILE A 274
TRP A 358
VAL A 289
ILE A 270
None
1.27A 5mvnD-5chsA:
3.1
5mvnD-5chsA:
14.24