SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5chv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 5chv UBL
CARBOXYL-TERMINAL
HYDROLASE 18
(Mus
musculus) 		5 / 12 ALA A 358
LEU A 275
GLY A 348
TYR A 347
LEU A 206
 None
 1.25A 1qabF-5chvA:
undetectable		 1qabF-5chvA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5chv UBL
CARBOXYL-TERMINAL
HYDROLASE 18
(Mus
musculus) 		3 / 3 LEU A 300
VAL A 338
ARG A 320
 None
 0.91A 3b0wB-5chvA:
undetectable		 3b0wB-5chvA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 5chv UBL
CARBOXYL-TERMINAL
HYDROLASE 18
(Mus
musculus) 		4 / 6 PHE A 165
PHE A  70
THR A 247
VAL A 362
 None
 1.31A 3lb3B-5chvA:
undetectable		 3lb3B-5chvA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5chv UBL
CARBOXYL-TERMINAL
HYDROLASE 18
(Mus
musculus) 		3 / 3 THR A 179
VAL A 176
GLU A 181
 None
 0.73A 3v4tA-5chvA:
undetectable
3v4tD-5chvA:
undetectable		 3v4tA-5chvA:
21.23
3v4tD-5chvA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5chv UBL
CARBOXYL-TERMINAL
HYDROLASE 18
(Mus
musculus) 		4 / 8 LEU A 361
VAL A 343
LEU A 206
TYR A 363
 None
 1.06A 3v81C-5chvA:
undetectable		 3v81C-5chvA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 5chv UBL
CARBOXYL-TERMINAL
HYDROLASE 18
(Mus
musculus) 		5 / 11 ILE A 144
PHE A 165
LEU A  67
LEU A 104
ILE A  83
 None
 1.15A 4dm8A-5chvA:
undetectable		 4dm8A-5chvA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 5chv UBL
CARBOXYL-TERMINAL
HYDROLASE 18
(Mus
musculus) 		5 / 11 PHE A  76
PHE A 165
LEU A  67
LEU A 104
ILE A  83
 None
 1.17A 4dm8A-5chvA:
undetectable		 4dm8A-5chvA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5chv UBL
CARBOXYL-TERMINAL
HYDROLASE 18
(Mus
musculus) 		4 / 8 LEU A 361
VAL A 343
LEU A 206
TYR A 363
 None
 1.01A 4pwdC-5chvA:
undetectable		 4pwdC-5chvA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 5chv UBL
CARBOXYL-TERMINAL
HYDROLASE 18
(Mus
musculus) 		6 / 8 GLY A  53
LEU A  54
ASN A  64
GLN A  68
ALA A 317
PHE A 330
 None
 0.25A 5xu8A-5chvA:
30.8		 5xu8A-5chvA:
29.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 5chv UBL
CARBOXYL-TERMINAL
HYDROLASE 18
(Mus
musculus) 		6 / 8 GLY A  53
LEU A  54
SER A  65
GLN A  68
ALA A 317
PHE A 330
 None
 0.56A 5xu8A-5chvA:
30.8		 5xu8A-5chvA:
29.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5chv UBL
CARBOXYL-TERMINAL
HYDROLASE 18
(Mus
musculus) 		3 / 3 LYS A 201
PRO A 202
LYS A 204
 None
None
CL  A 403 ( 4.6A)
 0.94A 5y9yA-5chvA:
undetectable		 5y9yA-5chvA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5chv UBL
CARBOXYL-TERMINAL
HYDROLASE 18
(Mus
musculus) 		3 / 3 ASN A  56
VAL A 129
HIS A 135
 None
SO4  A 402 ( 4.0A)
SO4  A 402 (-3.5A)
 0.75A 6a5yD-5chvA:
undetectable		 6a5yD-5chvA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 5chv UBL
CARBOXYL-TERMINAL
HYDROLASE 18
(Mus
musculus) 		4 / 8 VAL A 303
ASN A 270
TYR A 347
GLU A 207
 None
 1.31A 6gneB-5chvA:
undetectable		 6gneB-5chvA:
21.00