SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5chx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 5chx XRCC4-MYH7-1590-1657
(Homo
sapiens) 		5 / 11 LEU A 126
ALA A  42
GLY A  45
ILE A  34
VAL A 122
 None
 0.89A 1t7jA-5chxA:
undetectable		 1t7jA-5chxA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5chx XRCC4-MYH7-1590-1657
(Homo
sapiens) 		5 / 9 PHE A  32
VAL A  22
LEU A  75
PHE A 111
LEU A  28
 None
MLY  A   4 ( 4.4A)
MLY  A   4 ( 4.2A)
None
None
 1.27A 1wrkA-5chxA:
undetectable
1wrkB-5chxA:
undetectable		 1wrkA-5chxA:
16.59
1wrkB-5chxA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5chx XRCC4-MYH7-1590-1657
(Homo
sapiens) 		5 / 9 LEU A 108
VAL A  22
ILE A   8
VAL A  33
PHE A 111
 MLY  A  99 ( 4.5A)
MLY  A   4 ( 4.4A)
None
None
None
 0.97A 3cs9C-5chxA:
undetectable		 3cs9C-5chxA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)		 5chx XRCC4-MYH7-1590-1657
(Homo
sapiens) 		5 / 12 LEU A 126
ALA A  42
GLY A  45
ILE A  34
VAL A 122
 None
 0.79A 3gguA-5chxA:
undetectable		 3gguA-5chxA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_1
(POL POLYPROTEIN)		 5chx XRCC4-MYH7-1590-1657
(Homo
sapiens) 		5 / 9 LEU A 126
ALA A  42
GLY A  45
ILE A  34
VAL A 122
 None
 0.79A 3u7sA-5chxA:
undetectable		 3u7sA-5chxA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 5chx XRCC4-MYH7-1590-1657
(Homo
sapiens) 		4 / 7 PHE A  95
PHE A 111
ALA A  73
LEU A  28
 None
None
MLY  A  72 ( 3.6A)
None
 0.75A 4ejgC-5chxA:
undetectable		 4ejgC-5chxA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 5chx XRCC4-MYH7-1590-1657
(Homo
sapiens) 		4 / 7 SER A  53
ALA A  56
GLY A  64
VAL A  67
 MLY  A  63 ( 3.7A)
MLY  A  63 ( 4.0A)
MLY  A  65 ( 2.4A)
MLY  A  63 ( 3.8A)
 0.66A 5fpdA-5chxA:
undetectable		 5fpdA-5chxA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5chx XRCC4-MYH7-1590-1657
(Homo
sapiens) 		5 / 12 LEU A  28
ILE A  34
LEU A 108
ALA A  73
TYR A  66
 None
None
MLY  A  99 ( 4.5A)
MLY  A  72 ( 3.6A)
None
 1.07A 6djzA-5chxA:
undetectable		 6djzA-5chxA:
21.48