SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ci6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
5 / 12 ALA A 342
MET A 328
LEU A 177
ILE A 253
LEU A 195
None
1.08A 1dreA-5ci6A:
undetectable
1dreA-5ci6A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
3 / 3 TRP A 228
HIS A 152
LYS A 191
None
1.29A 1l7xA-5ci6A:
undetectable
1l7xA-5ci6A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
5 / 12 ALA A 342
MET A 328
LEU A 177
ILE A 253
LEU A 195
None
1.09A 1rx3A-5ci6A:
undetectable
1rx3A-5ci6A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
4 / 7 ASP A 353
ASP A 356
LYS A 178
HIS A 119
None
1.43A 1t03A-5ci6A:
undetectable
1t03A-5ci6A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
4 / 6 ILE A  69
VAL A  77
ILE A 122
ASP A 207
None
0.70A 1uwhA-5ci6A:
21.3
1uwhA-5ci6A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
5 / 7 ILE A  69
LYS A  92
LEU A 114
ILE A 122
ASP A 207
None
1.02A 1uwjA-5ci6A:
7.8
1uwjA-5ci6A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
5 / 12 LEU A 195
LEU A 196
ILE A 122
GLY A 176
LEU A 177
None
1.26A 2j7xA-5ci6A:
undetectable
2j7xA-5ci6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
6 / 12 ILE A  69
VAL A  77
ALA A  90
LEU A 146
MET A 147
LEU A 196
None
0.61A 2y7jA-5ci6A:
24.5
2y7jA-5ci6A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
6 / 10 ILE A  69
VAL A  77
ALA A  90
LEU A 146
MET A 147
LEU A 196
None
0.56A 2y7jB-5ci6A:
24.7
2y7jB-5ci6A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
6 / 10 ILE A  69
VAL A  77
ALA A  90
LEU A 146
MET A 147
LEU A 196
None
0.61A 2y7jC-5ci6A:
24.6
2y7jC-5ci6A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
6 / 10 ILE A  69
VAL A  77
ALA A  90
LEU A 146
MET A 147
LEU A 196
None
0.52A 2y7jD-5ci6A:
24.8
2y7jD-5ci6A:
23.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
5 / 8 ALA A  90
LYS A  92
GLU A 110
LEU A 146
MET A 147
None
0.86A 3lfaA-5ci6A:
34.7
3lfaA-5ci6A:
44.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
6 / 11 ILE A  69
ALA A  90
LYS A  92
VAL A 123
MET A 147
LEU A 196
None
0.54A 3miyA-5ci6A:
22.0
3miyA-5ci6A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
5 / 9 ILE A  69
ALA A  90
LYS A  92
MET A 147
LEU A 196
None
0.56A 3miyB-5ci6A:
21.9
3miyB-5ci6A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
4 / 6 VAL A  77
VAL A 123
ILE A 142
MET A 147
None
0.80A 3mssD-5ci6A:
20.9
3mssD-5ci6A:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
5 / 12 ALA A 342
MET A 328
LEU A 177
ILE A 253
LEU A 195
None
1.17A 3ql0A-5ci6A:
undetectable
3ql0A-5ci6A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
4 / 8 VAL A 123
LEU A 196
ILE A 205
CYH A 206
None
0.27A 3wzeA-5ci6A:
20.4
3wzeA-5ci6A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
6 / 12 ALA A  90
LEU A 146
MET A 147
ASP A 150
LEU A 196
ASP A 207
None
0.66A 3zbfA-5ci6A:
16.2
3zbfA-5ci6A:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
4 / 6 VAL A 123
LEU A 196
ILE A 205
CYH A 206
None
0.28A 4asdA-5ci6A:
20.2
4asdA-5ci6A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
7 / 12 ALA A  90
LYS A  92
GLU A 110
LEU A 114
ILE A 142
HIS A 187
ASP A 207
None
1.15A 4c8bA-5ci6A:
21.2
4c8bA-5ci6A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
7 / 12 ALA A  90
LYS A  92
LEU A 114
ILE A 142
HIS A 187
LEU A 196
ASP A 207
None
0.92A 4c8bA-5ci6A:
21.2
4c8bA-5ci6A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
4 / 5 VAL A  77
ILE A 122
MET A 147
ILE A 205
None
0.76A 4c8bA-5ci6A:
21.2
4c8bA-5ci6A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
4 / 8 VAL A 339
HIS A 187
ASP A 246
HIS A 181
None
0.85A 4exsB-5ci6A:
undetectable
4exsB-5ci6A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
3 / 3 ARG A 175
GLU A 120
ASN A 121
None
0.73A 4imaD-5ci6A:
undetectable
4imaD-5ci6A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
3 / 3 ARG A 175
GLU A 120
ASN A 121
None
0.71A 4ip7D-5ci6A:
undetectable
4ip7D-5ci6A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
5 / 12 LEU A 195
LEU A 196
ILE A 122
GLY A 176
LEU A 177
None
1.30A 4j26A-5ci6A:
undetectable
4j26A-5ci6A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
3 / 3 LYS A 191
PRO A 192
SER A 193
None
0.37A 4k50I-5ci6A:
undetectable
4k50I-5ci6A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
3 / 3 LEU A 133
ARG A 134
MET A 378
None
0.90A 4m11C-5ci6A:
undetectable
4m11C-5ci6A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
6 / 12 ILE A  69
ALA A  90
LYS A  92
GLU A 110
ILE A 142
ASP A 207
None
0.79A 4qmnA-5ci6A:
23.5
4qmnA-5ci6A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
5 / 10 ILE A  69
ALA A  90
LYS A  92
LEU A 146
LEU A 196
None
0.87A 4rz7A-5ci6A:
10.4
4rz7A-5ci6A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
7 / 12 ALA A  90
LYS A  92
LEU A 114
HIS A 187
LEU A 196
CYH A 206
ASP A 207
None
1.07A 4u0iA-5ci6A:
20.3
4u0iA-5ci6A:
24.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
4 / 6 ALA A  90
LEU A 146
MET A 147
LEU A 196
None
0.32A 4xoyA-5ci6A:
37.7
4xoyA-5ci6A:
49.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
4 / 6 ALA A  90
LEU A 146
MET A 147
LEU A 196
None
0.30A 4xp3A-5ci6A:
38.3
4xp3A-5ci6A:
49.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
4 / 8 VAL A 339
HIS A 187
ASP A 246
HIS A 181
None
0.83A 5a5zA-5ci6A:
undetectable
5a5zA-5ci6A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
5 / 11 LEU A 195
LEU A 196
ILE A 122
GLY A 176
LEU A 177
None
1.22A 5dxbB-5ci6A:
undetectable
5dxbB-5ci6A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
5 / 12 LYS A 191
LEU A 235
LEU A 236
GLU A 233
LEU A 234
None
1.11A 5nwwA-5ci6A:
undetectable
5nwwA-5ci6A:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
4 / 5 LEU A 343
LEU A 340
MET A 328
TYR A 347
None
1.43A 5uc3A-5ci6A:
undetectable
5uc3A-5ci6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNM_A_1N1A1001_1
(-)
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana)
8 / 12 ILE A  69
VAL A  77
ALA A  90
LYS A  92
GLU A 110
ILE A 142
MET A 147
LEU A 196
None
0.63A 6fnmA-5ci6A:
22.2
6fnmA-5ci6A:
26.11