SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cio'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		3 / 3 GLN A 175
ILE A 126
HIS A  48
 None
None
ZN  A 801 (-3.2A)
 0.69A 1fm9A-5cioA:
undetectable		 1fm9A-5cioA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		3 / 3 GLN A 175
ILE A 126
HIS A  52
 None
None
ZN  A 801 (-3.2A)
 0.61A 1fm9A-5cioA:
undetectable		 1fm9A-5cioA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 11 LEU A 326
LEU A 323
GLU A 319
LEU A 246
LEU A 266
 None
 1.28A 1g50A-5cioA:
undetectable		 1g50A-5cioA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		3 / 3 GLU A 314
HIS A 309
ASP A 285
 None
 0.86A 1i9gA-5cioA:
undetectable		 1i9gA-5cioA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		3 / 3 GLN A 175
ILE A 126
HIS A  48
 None
None
ZN  A 801 (-3.2A)
 0.67A 1k74A-5cioA:
undetectable		 1k74A-5cioA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		3 / 3 GLN A 175
ILE A 126
HIS A  52
 None
None
ZN  A 801 (-3.2A)
 0.57A 1k74A-5cioA:
undetectable		 1k74A-5cioA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		4 / 6 TRP A 373
ARG A 261
GLY A 257
ASP A 371
 None
 1.05A 1kf6M-5cioA:
undetectable
1kf6N-5cioA:
undetectable		 1kf6M-5cioA:
21.50
1kf6N-5cioA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		3 / 3 ARG A 245
ARG A 146
ARG A 288
 None
 1.01A 1l7fA-5cioA:
undetectable		 1l7fA-5cioA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		3 / 3 ARG A 245
ARG A 146
ARG A 288
 None
 1.00A 1l7hA-5cioA:
undetectable		 1l7hA-5cioA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		4 / 5 GLU A 495
ARG A 279
ASP A 269
LEU A 267
 None
 1.23A 1n13B-5cioA:
undetectable
1n13C-5cioA:
undetectable		 1n13B-5cioA:
8.26
1n13C-5cioA:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 12 LEU A 200
LEU A 203
LEU A 206
ALA A 207
LEU A 192
 None
 0.98A 1s9pC-5cioA:
undetectable		 1s9pC-5cioA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		4 / 4 LEU A 503
PRO A 733
ILE A 512
LEU A 456
 None
 1.09A 1ya4B-5cioA:
undetectable		 1ya4B-5cioA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 12 ALA A  80
HIS A  52
GLU A  51
HIS A  48
GLU A 129
 None
ZN  A 801 (-3.2A)
None
ZN  A 801 (-3.2A)
ZN  A 801 (-2.6A)
 0.80A 2c6nA-5cioA:
undetectable		 2c6nA-5cioA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 11 ALA A 477
LEU A 505
LEU A 503
LEU A 523
ASN A 520
 None
 1.06A 2ceoA-5cioA:
undetectable		 2ceoA-5cioA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 10 ALA A 477
LEU A 505
LEU A 503
LEU A 523
ASN A 520
 None
 1.06A 2ceoB-5cioA:
undetectable		 2ceoB-5cioA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		4 / 5 ARG A 693
THR A 613
LEU A 554
ALA A 689
 None
 1.34A 2e1qD-5cioA:
undetectable		 2e1qD-5cioA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 11 LEU A 554
ALA A 681
GLY A 662
ALA A 550
ILE A 551
 None
 0.92A 2idwA-5cioA:
undetectable		 2idwA-5cioA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 10 ALA A 477
LEU A 505
LEU A 503
LEU A 523
ASN A 520
 None
 1.03A 2riwA-5cioA:
undetectable
2riwB-5cioA:
undetectable		 2riwA-5cioA:
16.77
2riwB-5cioA:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_1
(PROTEASE RETROPEPSIN)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 12 LEU A 554
ALA A 681
GLY A 662
ALA A 550
ILE A 551
 None
 0.89A 2rkfA-5cioA:
undetectable		 2rkfA-5cioA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 9 ALA A  39
ALA A  34
GLY A 295
SER A  36
ALA A  84
 None
 1.45A 2vh3A-5cioA:
undetectable		 2vh3A-5cioA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		4 / 8 LEU A 614
LEU A 558
ALA A 556
HIS A 670
 None
 1.03A 2wekA-5cioA:
undetectable		 2wekA-5cioA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 10 ALA A 477
LEU A 505
LEU A 503
LEU A 523
ASN A 520
 None
 1.08A 2xn7A-5cioA:
undetectable
2xn7B-5cioA:
undetectable		 2xn7A-5cioA:
18.11
2xn7B-5cioA:
3.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 10 LEU A 554
ALA A 681
GLY A 662
ALA A 550
ILE A 551
 None
 1.00A 3ekpC-5cioA:
undetectable		 3ekpC-5cioA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 10 LEU A 474
ALA A 522
GLY A 515
LEU A 516
VAL A 494
 None
 0.77A 3em3A-5cioA:
undetectable		 3em3A-5cioA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 12 CYH A 141
ALA A 143
ALA A 144
GLN A 147
LEU A 408
 None
 0.79A 3fc6C-5cioA:
undetectable		 3fc6C-5cioA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 12 CYH A 141
ALA A 143
ALA A 144
LEU A 408
LEU A 404
 None
 0.93A 3fc6C-5cioA:
undetectable		 3fc6C-5cioA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FGR_B_ACTB21_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		4 / 4 ARG A 279
ASP A 268
ASP A 269
PRO A 480
 None
 1.02A 3fgrB-5cioA:
undetectable		 3fgrB-5cioA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		4 / 4 LEU A 404
PRO A 405
LEU A 406
ARG A 245
 None
 1.39A 3hcoA-5cioA:
undetectable		 3hcoA-5cioA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		3 / 3 ARG A 553
ASP A 136
GLN A 243
 None
 0.90A 3lcvB-5cioA:
undetectable		 3lcvB-5cioA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TF1_A_ACTA191_0
(METHYL-ACCEPTING
CHEMOTAXIS PROTEIN)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		4 / 5 THR A  87
ILE A  32
PHE A  89
LEU A  50
 None
 1.40A 3tf1A-5cioA:
0.8		 3tf1A-5cioA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		4 / 7 ARG A 736
ALA A 737
ILE A 740
GLY A 578
 None
 0.97A 3v4tH-5cioA:
undetectable		 3v4tH-5cioA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 12 PRO A 454
LEU A 583
LEU A 587
ILE A 512
PHE A 594
 None
 0.98A 4a7aB-5cioA:
undetectable		 4a7aB-5cioA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 12 PHE A 411
LEU A 391
VAL A 307
ALA A 316
SER A 313
 None
 1.34A 4a84A-5cioA:
2.7		 4a84A-5cioA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 12 LEU A 562
VAL A 612
PRO A 628
PHE A 669
GLY A 636
 None
 1.17A 4hvcB-5cioA:
undetectable		 4hvcB-5cioA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 11 LEU A 391
LEU A 408
CYH A 141
LEU A 388
ALA A 389
 None
 1.14A 4p65B-5cioA:
undetectable
4p65D-5cioA:
undetectable
4p65G-5cioA:
undetectable
4p65H-5cioA:
undetectable		 4p65B-5cioA:
3.52
4p65D-5cioA:
3.52
4p65G-5cioA:
11.01
4p65H-5cioA:
3.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 12 LEU A 562
VAL A 612
PRO A 628
PHE A 669
GLY A 636
 None
 1.13A 4q15A-5cioA:
undetectable		 4q15A-5cioA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 12 LEU A 562
VAL A 612
PRO A 628
PHE A 669
GLY A 636
 None
 1.08A 4q15B-5cioA:
undetectable		 4q15B-5cioA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 12 GLN A 174
LEU A  49
ALA A 116
GLY A 167
ASP A 169
 None
 1.16A 4qckA-5cioA:
undetectable		 4qckA-5cioA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		4 / 8 LEU A 503
PRO A 460
LEU A 457
VAL A 500
 None
 1.09A 4qknA-5cioA:
undetectable		 4qknA-5cioA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 12 PHE A 303
PHE A 248
LEU A 380
LEU A 262
LEU A 259
 None
 1.28A 4xumA-5cioA:
undetectable		 4xumA-5cioA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 12 LEU A 562
VAL A 612
PRO A 628
PHE A 669
GLY A 636
 None
 1.11A 4ydqA-5cioA:
undetectable		 4ydqA-5cioA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		4 / 5 ALA A 556
HIS A 463
ALA A 560
GLU A 468
 None
 0.96A 5a06C-5cioA:
undetectable
5a06D-5cioA:
undetectable		 5a06C-5cioA:
18.90
5a06D-5cioA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		3 / 3 THR A 718
HIS A 705
LEU A 760
 None
 0.81A 5axdA-5cioA:
undetectable		 5axdA-5cioA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 9 ALA A  34
THR A  82
HIS A  48
ILE A  32
SER A  36
 None
None
ZN  A 801 (-3.2A)
None
None
 1.26A 5eeuA-5cioA:
undetectable
5eeuK-5cioA:
undetectable		 5eeuA-5cioA:
6.05
5eeuK-5cioA:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 9 ALA A  34
THR A  82
HIS A  48
ILE A  32
SER A  36
 None
None
ZN  A 801 (-3.2A)
None
None
 1.26A 5eevA-5cioA:
undetectable
5eevK-5cioA:
undetectable		 5eevA-5cioA:
6.05
5eevK-5cioA:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 9 ALA A  34
THR A  82
HIS A  48
ILE A  32
SER A  36
 None
None
ZN  A 801 (-3.2A)
None
None
 1.26A 5eewA-5cioA:
undetectable
5eewK-5cioA:
undetectable		 5eewA-5cioA:
6.05
5eewK-5cioA:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 10 ALA A  34
THR A  82
HIS A  48
ILE A  32
SER A  36
 None
None
ZN  A 801 (-3.2A)
None
None
 1.26A 5eexA-5cioA:
undetectable
5eexK-5cioA:
undetectable		 5eexA-5cioA:
6.05
5eexK-5cioA:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 9 ALA A  34
THR A  82
HIS A  48
ILE A  32
SER A  36
 None
None
ZN  A 801 (-3.2A)
None
None
 1.27A 5eeyA-5cioA:
undetectable
5eeyK-5cioA:
undetectable		 5eeyA-5cioA:
6.05
5eeyK-5cioA:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 9 ALA A  34
THR A  82
HIS A  48
ILE A  32
SER A  36
 None
None
ZN  A 801 (-3.2A)
None
None
 1.27A 5eezA-5cioA:
undetectable
5eezK-5cioA:
undetectable		 5eezA-5cioA:
6.05
5eezK-5cioA:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 10 ALA A  34
THR A  82
HIS A  48
ILE A  32
SER A  36
 None
None
ZN  A 801 (-3.2A)
None
None
 1.27A 5ef0A-5cioA:
undetectable
5ef0K-5cioA:
undetectable		 5ef0A-5cioA:
6.05
5ef0K-5cioA:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 9 ALA A  34
THR A  82
HIS A  48
ILE A  32
SER A  36
 None
None
ZN  A 801 (-3.2A)
None
None
 1.26A 5ef1A-5cioA:
undetectable
5ef1K-5cioA:
undetectable		 5ef1A-5cioA:
6.05
5ef1K-5cioA:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 9 ALA A  34
THR A  82
HIS A  48
ILE A  32
SER A  36
 None
None
ZN  A 801 (-3.2A)
None
None
 1.27A 5ef2A-5cioA:
undetectable
5ef2K-5cioA:
undetectable		 5ef2A-5cioA:
6.05
5ef2K-5cioA:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 10 ALA A  34
THR A  82
HIS A  48
ILE A  32
SER A  36
 None
None
ZN  A 801 (-3.2A)
None
None
 1.26A 5ef3A-5cioA:
undetectable
5ef3K-5cioA:
undetectable		 5ef3A-5cioA:
6.05
5ef3K-5cioA:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 12 LEU A 562
VAL A 612
PRO A 628
PHE A 669
GLY A 636
 None
 1.21A 5f9zA-5cioA:
undetectable		 5f9zA-5cioA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 12 LEU A 562
VAL A 612
PRO A 628
PHE A 669
GLY A 636
 None
 1.21A 5f9zB-5cioA:
undetectable		 5f9zB-5cioA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		4 / 8 LEU A 726
LEU A 640
THR A 668
GLN A  72
 None
 1.20A 5hbsA-5cioA:
undetectable		 5hbsA-5cioA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		3 / 3 THR A 708
MET A 703
HIS A 704
 None
 1.01A 5uunA-5cioA:
undetectable		 5uunA-5cioA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		3 / 3 ARG A 360
ARG A 260
ARG A 358
 None
 0.96A 5vcgA-5cioA:
undetectable		 5vcgA-5cioA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 12 LEU A 562
VAL A 612
PRO A 628
PHE A 669
GLY A 636
 None
 1.20A 5xipA-5cioA:
undetectable		 5xipA-5cioA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 12 LEU A 562
VAL A 612
PRO A 628
PHE A 669
GLY A 636
 None
 1.17A 5xipC-5cioA:
undetectable		 5xipC-5cioA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 12 LEU A 562
VAL A 612
PRO A 628
PHE A 669
GLY A 636
 None
 1.18A 5xiqA-5cioA:
undetectable		 5xiqA-5cioA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 12 LEU A 562
VAL A 612
PRO A 628
PHE A 669
GLY A 636
 None
 1.18A 5xiqD-5cioA:
undetectable		 5xiqD-5cioA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		3 / 3 GLN A 175
ILE A 126
HIS A  48
 None
None
ZN  A 801 (-3.2A)
 0.53A 5z12B-5cioA:
undetectable		 5z12B-5cioA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		3 / 3 GLN A 175
ILE A 126
HIS A  52
 None
None
ZN  A 801 (-3.2A)
 0.52A 5z12B-5cioA:
undetectable		 5z12B-5cioA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		5 / 12 LEU A 203
ALA A 103
TRP A  70
PHE A  91
VAL A  93
 None
 1.40A 6drxA-5cioA:
undetectable		 6drxA-5cioA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF
(Serratia
sp.
FS14) 		4 / 5 LEU A 391
THR A 235
THR A 407
GLY A 409
 None
 0.98A 6gtqA-5cioA:
undetectable		 6gtqA-5cioA:
14.03