SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5civ'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5civ SIBLING BACTERIOCIN
(Paenibacillus
dendritiformis) 		5 / 12 PHE A 170
TYR A  63
ALA A 105
SER A 102
ALA A 108
 None
 1.21A 2igtC-5civA:
undetectable		 2igtC-5civA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 5civ SIBLING BACTERIOCIN
(Paenibacillus
dendritiformis) 		4 / 6 ASP A 131
ILE A 130
LEU A  23
GLU A 123
 None
 1.07A 2ya7A-5civA:
undetectable		 2ya7A-5civA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 5civ SIBLING BACTERIOCIN
(Paenibacillus
dendritiformis) 		4 / 6 ASP A 131
ILE A 130
LEU A  23
GLU A 123
 None
 1.06A 2ya7D-5civA:
undetectable		 2ya7D-5civA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M7T_A_SAMA503_0
(BTRN)		 5civ SIBLING BACTERIOCIN
(Paenibacillus
dendritiformis) 		5 / 11 TYR A 107
TYR A  31
THR A 122
LEU A 118
LEU A 110
 None
 1.30A 4m7tA-5civA:
undetectable		 4m7tA-5civA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 5civ SIBLING BACTERIOCIN
(Paenibacillus
dendritiformis) 		5 / 12 TYR A  31
LEU A  34
ASP A  35
LEU A  68
ILE A  60
 None
 0.98A 4odrA-5civA:
undetectable
4odrB-5civA:
undetectable		 4odrA-5civA:
17.39
4odrB-5civA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 5civ SIBLING BACTERIOCIN
(Paenibacillus
dendritiformis) 		3 / 3 TRP A 129
ILE A 159
GLU A 123
 None
 0.56A 6hcxA-5civA:
undetectable		 6hcxA-5civA:
18.64