SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cj4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 5cj4 XRCC4-MYH7-(1562-162
2) CHIMERA PROTEIN
(Homo
sapiens) 		5 / 12 LEU A  70
PHE A  97
LEU A  20
ILE A   8
SER A   6
 None
 1.18A 2ydoA-5cj4A:
undetectable		 2ydoA-5cj4A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)		 5cj4 XRCC4-MYH7-(1562-162
2) CHIMERA PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 126
ALA A  42
GLY A  45
ILE A  34
VAL A 122
 None
 0.81A 3gguA-5cj4A:
undetectable		 3gguA-5cj4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_1
(POL POLYPROTEIN)		 5cj4 XRCC4-MYH7-(1562-162
2) CHIMERA PROTEIN
(Homo
sapiens) 		5 / 9 LEU A 126
ALA A  42
GLY A  45
ILE A  34
VAL A 122
 None
 0.80A 3u7sA-5cj4A:
undetectable		 3u7sA-5cj4A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 5cj4 XRCC4-MYH7-(1562-162
2) CHIMERA PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 126
ALA A  42
GLY A  45
ILE A  34
VAL A 122
 None
 0.85A 3ucbA-5cj4A:
undetectable		 3ucbA-5cj4A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 5cj4 XRCC4-MYH7-(1562-162
2) CHIMERA PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 126
ALA A  42
GLY A  45
ILE A  34
VAL A 122
 None
 0.88A 3ucbB-5cj4A:
undetectable		 3ucbB-5cj4A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5cj4 XRCC4-MYH7-(1562-162
2) CHIMERA PROTEIN
(Homo
sapiens) 		5 / 12 TYR A  66
PHE A  97
ILE A  34
VAL A  22
LEU A  20
 None
None
None
MLY  A   4 ( 4.2A)
None
 1.16A 3w68A-5cj4A:
undetectable		 3w68A-5cj4A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5cj4 XRCC4-MYH7-(1562-162
2) CHIMERA PROTEIN
(Homo
sapiens) 		5 / 12 VAL A  22
LEU A  36
SER A   6
PHE A  86
ARG A  71
 MLY  A   4 ( 4.2A)
None
None
None
None
 1.35A 5hnxB-5cj4A:
undetectable		 5hnxB-5cj4A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 5cj4 XRCC4-MYH7-(1562-162
2) CHIMERA PROTEIN
(Homo
sapiens) 		3 / 3 ARG A1608
ARG A1613
ARG A1606
 MLY  A1615 ( 4.2A)
None
None
 0.81A 5vcgA-5cj4A:
undetectable		 5vcgA-5cj4A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5cj4 XRCC4-MYH7-(1562-162
2) CHIMERA PROTEIN
(Homo
sapiens) 		5 / 12 LEU A  28
ILE A  34
LEU A 108
ALA A  73
TYR A  66
 None
None
MLY  A  99 ( 4.8A)
MLY  A  72 ( 3.6A)
None
 1.12A 6djzA-5cj4A:
undetectable		 6djzA-5cj4A:
22.13