SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cjp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 5cjp RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP2
(Homo
sapiens) 		5 / 12 LEU E 984
LEU E 981
LEU E1069
ILE E1063
ILE E1113
 None
 1.13A 1tw4B-5cjpE:
undetectable		 1tw4B-5cjpE:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 5cjp RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP2
(Homo
sapiens) 		5 / 12 LEU E1103
ASN E1102
LEU E1104
VAL E1079
LEU E 943
 None
 1.36A 2q7kA-5cjpE:
undetectable		 2q7kA-5cjpE:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 5cjp RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP2
(Homo
sapiens) 		5 / 11 GLY E1139
ILE E1000
THR E1055
LEU E1051
THR E1002
 None
 1.32A 3bf1C-5cjpE:
undetectable
3bf1D-5cjpE:
undetectable		 3bf1C-5cjpE:
21.83
3bf1D-5cjpE:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 5cjp RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP2
(Homo
sapiens) 		4 / 6 THR E 980
ILE E 919
TYR E 923
ASP E1120
 None
 1.11A 3q70A-5cjpE:
undetectable		 3q70A-5cjpE:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 5cjp RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP2
(Homo
sapiens) 		4 / 5 GLY E1072
TYR E 933
TYR E1075
GLU E1189
 None
 1.19A 4ae1B-5cjpE:
undetectable		 4ae1B-5cjpE:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5cjp RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP2
(Homo
sapiens) 		5 / 12 ILE E 992
ARG E1135
GLY E1139
ALA E1142
VAL E1058
 None
 1.14A 4nkvA-5cjpE:
undetectable		 4nkvA-5cjpE:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 5cjp RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP2
(Homo
sapiens) 		4 / 6 LEU E1103
ASN E1102
LEU E 943
VAL E 951
 None
 1.02A 4okbA-5cjpE:
undetectable		 4okbA-5cjpE:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 5cjp RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP2
(Homo
sapiens) 		4 / 6 PRO E 987
TYR E1105
LEU E1068
LEU E 981
 None
 1.06A 5tl8A-5cjpE:
undetectable		 5tl8A-5cjpE:
22.22