SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cju'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		3 / 3 ALA A 355
VAL A 391
TRP A 368
 None
 0.91A 1av2A-5cjuA:
undetectable
1av2B-5cjuA:
undetectable		 1av2A-5cjuA:
2.13
1av2B-5cjuA:
2.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		3 / 3 TRP A 368
ALA A 355
VAL A 391
 None
 0.86A 1av2C-5cjuA:
undetectable
1av2D-5cjuA:
undetectable		 1av2C-5cjuA:
2.13
1av2D-5cjuA:
2.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 11 ALA A 414
LEU A 415
LEU A 411
LEU A 229
ILE A 308
 None
 1.04A 1ha2A-5cjuA:
undetectable		 1ha2A-5cjuA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 6 ASP A  40
GLY A 741
ILE A 981
ARG A 978
 B12  A1101 (-3.5A)
None
None
None
 0.89A 1mt1G-5cjuA:
undetectable
1mt1J-5cjuA:
0.0		 1mt1G-5cjuA:
4.03
1mt1J-5cjuA:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		3 / 3 PHE A 771
LEU A 688
MET A 756
 None
 0.86A 1mx1D-5cjuA:
2.4		 1mx1D-5cjuA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P5Z_B_AR3B304_1
(DEOXYCYTIDINE KINASE)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 12 LEU A 512
ARG A 848
ASP A 855
PHE A 578
GLU A 509
 None
 1.39A 1p5zB-5cjuA:
5.8		 1p5zB-5cjuA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_A_ADNA1245_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 9 ARG A1053
GLY A1076
GLU A1084
SER A1074
ASP A 636
 None
 1.39A 1pk7A-5cjuA:
undetectable		 1pk7A-5cjuA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		3 / 3 ALA A 355
VAL A 391
TRP A 368
 None
 0.88A 1w5uA-5cjuA:
undetectable
1w5uB-5cjuA:
undetectable		 1w5uA-5cjuA:
2.13
1w5uB-5cjuA:
2.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		3 / 3 TRP A 368
ALA A 355
VAL A 391
 None
 0.85A 1w5uA-5cjuA:
undetectable
1w5uB-5cjuA:
undetectable		 1w5uA-5cjuA:
2.13
1w5uB-5cjuA:
2.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 10 PHE A 747
THR A 686
LEU A1066
VAL A1062
VAL A1085
 None
 1.35A 2cp4A-5cjuA:
undetectable		 2cp4A-5cjuA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 11 ILE A  81
HIS A 108
LEU A  74
ARG A 178
GLY A  80
 None
 1.27A 2fn1A-5cjuA:
undetectable		 2fn1A-5cjuA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 12 ASN A1061
ALA A1064
VAL A 731
PHE A 763
HIS A 766
 None
 1.31A 2gl0A-5cjuA:
undetectable
2gl0C-5cjuA:
undetectable		 2gl0A-5cjuA:
10.33
2gl0C-5cjuA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		3 / 3 ALA A 355
VAL A 391
TRP A 368
 None
 0.85A 2izqA-5cjuA:
undetectable
2izqB-5cjuA:
undetectable		 2izqA-5cjuA:
2.13
2izqB-5cjuA:
2.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		3 / 3 TRP A 368
ALA A 355
VAL A 391
 None
 0.98A 2izqC-5cjuA:
undetectable
2izqD-5cjuA:
undetectable		 2izqC-5cjuA:
2.13
2izqD-5cjuA:
2.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 5 ALA A1020
ALA A 902
ALA A 918
VAL A 614
 None
 0.94A 2nyrB-5cjuA:
undetectable		 2nyrB-5cjuA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 6 LEU A 161
TYR A 164
ILE A 109
ILE A 159
 None
 1.00A 2q8hA-5cjuA:
undetectable		 2q8hA-5cjuA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 10 ASP A 880
SER A 624
LEU A 885
THR A 884
GLY A 868
 None
BCO  A1103 (-3.4A)
None
None
5AD  A1102 ( 3.5A)
 1.33A 2v0mA-5cjuA:
undetectable		 2v0mA-5cjuA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSC_A_PQNA1802_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 9 PHE A 747
ARG A1053
ALA A1081
LEU A1082
GLY A1086
 None
 1.44A 2wscA-5cjuA:
3.1		 2wscA-5cjuA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSE_A_PQNA1801_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 9 PHE A 747
ARG A1053
ALA A1081
LEU A1082
GLY A1086
 None
 1.44A 2wseA-5cjuA:
3.2		 2wseA-5cjuA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSF_A_PQNA1802_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 9 PHE A 747
ARG A1053
ALA A1081
LEU A1082
GLY A1086
 None
 1.43A 2wsfA-5cjuA:
undetectable		 2wsfA-5cjuA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 8 GLY A 741
HIS A 780
ASN A 798
ALA A 784
 None
BCO  A1103 ( 3.8A)
None
B12  A1101 (-3.7A)
 0.83A 2x0pA-5cjuA:
undetectable		 2x0pA-5cjuA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 12 PHE A 611
TYR A 664
ALA A 599
ALA A 626
MET A 690
 None
None
None
B12  A1101 (-3.6A)
None
 1.30A 2x2nB-5cjuA:
undetectable		 2x2nB-5cjuA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 12 PHE A 611
TYR A 664
ALA A 599
ALA A 626
MET A 690
 None
None
None
B12  A1101 (-3.6A)
None
 1.32A 2x2nC-5cjuA:
undetectable		 2x2nC-5cjuA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 7 GLY A 190
ASN A 189
ALA A 291
VAL A 295
 None
 0.74A 3a2qA-5cjuA:
undetectable		 3a2qA-5cjuA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 7 VAL A  91
LYS A  95
ILE A  98
LEU A  74
 None
 0.75A 3bjwH-5cjuA:
undetectable		 3bjwH-5cjuA:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 5 LYS A 553
TYR A 862
GLU A 590
GLU A 935
 None
 1.43A 3dh0B-5cjuA:
undetectable		 3dh0B-5cjuA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 7 ILE A  43
GLY A 113
VAL A  69
LEU A  50
 None
B12  A1101 ( 4.8A)
None
None
 0.88A 3elzA-5cjuA:
undetectable		 3elzA-5cjuA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 5 ILE A 776
THR A 730
PHE A 771
PHE A 763
 None
BCO  A1103 (-3.2A)
None
None
 1.28A 3em0A-5cjuA:
undetectable		 3em0A-5cjuA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 12 VAL A 295
CYH A 299
ALA A 301
ALA A 302
LEU A 200
 None
 0.77A 3fc6C-5cjuA:
undetectable		 3fc6C-5cjuA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 6 LEU A 556
ASN A 936
TRP A 568
PHE A 559
 None
 1.23A 3i9jB-5cjuA:
2.6		 3i9jB-5cjuA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 7 LEU A 736
VAL A 768
ILE A 759
ARG A 728
 None
None
None
BCO  A1103 (-3.6A)
 1.19A 3ik3B-5cjuA:
undetectable		 3ik3B-5cjuA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		3 / 3 TRP A 368
ALA A 355
VAL A 391
 None
 0.93A 3l8lC-5cjuA:
undetectable
3l8lD-5cjuA:
undetectable		 3l8lC-5cjuA:
2.13
3l8lD-5cjuA:
2.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 9 PHE A 747
ARG A1053
ALA A1081
LEU A1082
GLY A1086
 None
 1.45A 3lw5A-5cjuA:
0.0		 3lw5A-5cjuA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 9 LEU A1066
LEU A1075
ILE A 687
ALA A 684
THR A1079
 None
 0.99A 3mdvA-5cjuA:
undetectable		 3mdvA-5cjuA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 12 LEU A1066
LEU A1075
ILE A 687
ALA A 684
THR A1079
 None
 1.00A 3mdvB-5cjuA:
undetectable		 3mdvB-5cjuA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 8 PHE A 822
ILE A 842
PHE A 800
VAL A 955
 None
 0.84A 3me6B-5cjuA:
undetectable		 3me6B-5cjuA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 10 ASP A 659
ALA A 604
GLY A 648
VAL A 647
ILE A 654
 None
 0.94A 3oxwD-5cjuA:
undetectable		 3oxwD-5cjuA:
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 6 VAL A 731
PHE A 763
VAL A 727
PHE A1063
 None
 1.14A 3soaA-5cjuA:
undetectable		 3soaA-5cjuA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 12 ILE A 274
LEU A 260
ALA A 181
PHE A 275
ILE A 246
 None
 1.08A 3w67C-5cjuA:
1.3		 3w67C-5cjuA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 6 ARG A 472
GLU A 562
LEU A 513
ASP A 561
 None
 1.47A 4cevA-5cjuA:
1.0
4cevB-5cjuA:
undetectable		 4cevA-5cjuA:
14.61
4cevB-5cjuA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 6 ASP A 561
ARG A 472
GLU A 562
LEU A 513
 None
 1.44A 4cevA-5cjuA:
1.0
4cevC-5cjuA:
undetectable		 4cevA-5cjuA:
14.61
4cevC-5cjuA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 6 ARG A 472
GLU A 562
LEU A 513
ASP A 561
 None
 1.47A 4cevD-5cjuA:
1.6
4cevE-5cjuA:
undetectable		 4cevD-5cjuA:
14.61
4cevE-5cjuA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 6 ARG A 472
GLU A 562
LEU A 513
ASP A 561
 None
 1.46A 4cevE-5cjuA:
undetectable
4cevF-5cjuA:
undetectable		 4cevE-5cjuA:
14.61
4cevF-5cjuA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 12 GLU A 310
MET A 266
LEU A 415
GLY A 213
ILE A 214
 MG  A1105 (-3.2A)
None
None
None
None
 1.47A 4djeA-5cjuA:
8.4		 4djeA-5cjuA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 6 PHE A 304
GLY A 175
LEU A 180
VAL A 172
 None
 1.03A 4dubA-5cjuA:
undetectable		 4dubA-5cjuA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 9 PHE A 747
THR A 686
LEU A1066
VAL A1062
VAL A1085
 None
 1.31A 4ek1B-5cjuA:
undetectable		 4ek1B-5cjuA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 7 GLY A 682
ILE A 735
GLU A 738
MET A 660
 None
 0.91A 4g0vA-5cjuA:
undetectable		 4g0vA-5cjuA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		6 / 11 PHE A 304
GLN A  75
ALA A 181
ALA A 179
THR A 171
LEU A 200
 None
 1.42A 4j6cA-5cjuA:
undetectable		 4j6cA-5cjuA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		6 / 10 PHE A 304
GLN A  75
ALA A 181
ALA A 179
THR A 171
LEU A 200
 None
 1.42A 4j6cB-5cjuA:
undetectable		 4j6cB-5cjuA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		6 / 12 PHE A 304
GLN A  75
ALA A 181
ALA A 179
THR A 171
LEU A 200
 None
 1.45A 4j6dA-5cjuA:
undetectable		 4j6dA-5cjuA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		6 / 12 PHE A 304
GLN A  75
ALA A 181
ALA A 179
THR A 171
LEU A 200
 None
 1.46A 4j6dB-5cjuA:
undetectable		 4j6dB-5cjuA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 12 GLN A  75
ALA A 181
ALA A 179
THR A 171
LEU A 200
 None
 1.08A 4jbtA-5cjuA:
undetectable		 4jbtA-5cjuA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 11 GLN A  75
ALA A 181
ALA A 179
THR A 171
LEU A 200
 None
 1.09A 4jbtB-5cjuA:
undetectable		 4jbtB-5cjuA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 9 PHE A1063
PHE A 771
ILE A 680
MET A 678
 None
 1.29A 4jvlA-5cjuA:
undetectable		 4jvlA-5cjuA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		3 / 3 ILE A  81
MET A 153
ARG A 156
 None
B12  A1101 ( 3.7A)
None
 0.76A 4lnwA-5cjuA:
undetectable		 4lnwA-5cjuA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		3 / 3 ILE A  81
MET A 153
ARG A 156
 None
B12  A1101 ( 3.7A)
None
 0.75A 4lnxA-5cjuA:
undetectable		 4lnxA-5cjuA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 8 PHE A 627
THR A 625
VAL A 676
PHE A 611
 None
 0.99A 4ltwA-5cjuA:
undetectable		 4ltwA-5cjuA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 6 MET A 660
MET A 690
LEU A1075
ILE A 643
 None
 1.06A 4okxA-5cjuA:
undetectable		 4okxA-5cjuA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 12 GLY A 106
ILE A 159
ILE A  81
VAL A  69
ILE A  83
 None
 1.00A 4q5mA-5cjuA:
undetectable		 4q5mA-5cjuA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		3 / 3 PHE A 959
THR A 581
LEU A 792
 None
 0.51A 4qztA-5cjuA:
undetectable		 4qztA-5cjuA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 12 ALA A 355
ILE A 356
ASN A 378
LEU A 348
GLN A 374
 None
 1.14A 4r38C-5cjuA:
undetectable		 4r38C-5cjuA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 12 GLY A 216
GLY A 219
ALA A 220
PRO A 250
GLN A  51
 None
GDP  A1104 (-3.2A)
GDP  A1104 (-4.8A)
None
None
 0.97A 4rtmA-5cjuA:
undetectable		 4rtmA-5cjuA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 6 ALA A 320
LYS A 286
THR A 215
THR A 311
 None
 1.44A 4w5rA-5cjuA:
2.4		 4w5rA-5cjuA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 6 ALA A 320
LYS A 286
THR A 215
THR A 311
 None
 1.48A 4w5tA-5cjuA:
undetectable		 4w5tA-5cjuA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 9 GLY A 648
ILE A 687
MET A 690
LEU A1075
THR A 631
 None
 1.26A 4x3mB-5cjuA:
undetectable		 4x3mB-5cjuA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 4 LEU A 292
ILE A 321
HIS A 324
VAL A 309
 None
 1.30A 4xyzA-5cjuA:
undetectable		 4xyzA-5cjuA:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y28_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 9 ARG A1053
ALA A1081
LEU A1082
GLY A1086
PHE A 771
 None
 1.34A 4y28A-5cjuA:
undetectable
4y28J-5cjuA:
undetectable		 4y28A-5cjuA:
20.30
4y28J-5cjuA:
4.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 6 ALA A 320
LYS A 286
THR A 215
THR A 311
 None
 1.45A 4z4cA-5cjuA:
2.1		 4z4cA-5cjuA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 7 VAL A 309
LEU A 292
SER A 289
GLU A 188
 None
 1.07A 4zphA-5cjuA:
undetectable
4zphB-5cjuA:
undetectable		 4zphA-5cjuA:
16.43
4zphB-5cjuA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 5 ALA A  32
ARG A1091
ALA A  72
GLU A  68
 None
 1.34A 5a06C-5cjuA:
2.2
5a06D-5cjuA:
3.7		 5a06C-5cjuA:
15.64
5a06D-5cjuA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 12 GLY A 410
GLY A 413
GLY A 416
LEU A 415
LEU A 329
 None
 0.99A 5c0oF-5cjuA:
undetectable		 5c0oF-5cjuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		3 / 3 ARG A 571
THR A 948
ASP A 949
 None
 0.85A 5g5gA-5cjuA:
undetectable
5g5gB-5cjuA:
undetectable		 5g5gA-5cjuA:
11.77
5g5gB-5cjuA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 12 ASP A 360
SER A 435
THR A 226
ARG A 265
ARG A 361
 GDP  A1104 (-3.0A)
None
None
GDP  A1104 (-3.5A)
None
 1.37A 5hnxB-5cjuA:
0.4		 5hnxB-5cjuA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 9 MET A 266
VAL A 331
LEU A 329
ILE A 214
TYR A 408
 None
 1.43A 5iepA-5cjuA:
undetectable		 5iepA-5cjuA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 12 ALA A 793
LEU A 796
ALA A 797
PHE A 800
THR A 801
 None
 0.40A 5k9dA-5cjuA:
1.7		 5k9dA-5cjuA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 5 ARG A 232
THR A 394
ALA A 396
ASP A 401
 None
None
GDP  A1104 (-3.8A)
None
 1.37A 5mfxA-5cjuA:
2.1		 5mfxA-5cjuA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 10 ILE A  43
ILE A  81
GLY A 113
LEU A  60
VAL A  69
 None
None
B12  A1101 ( 4.8A)
None
None
 1.08A 5twjB-5cjuA:
undetectable		 5twjB-5cjuA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 12 LEU A 212
ILE A 321
ILE A 308
SER A 328
LEU A 329
 None
 1.12A 5twjC-5cjuA:
2.4		 5twjC-5cjuA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		3 / 3 GLU A 639
HIS A 638
ARG A 640
 None
 0.63A 5uunA-5cjuA:
0.0		 5uunA-5cjuA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 5 ASN A  44
ASP A  40
ASN A 743
ASP A 739
 None
B12  A1101 (-3.5A)
B12  A1101 ( 4.6A)
None
 1.25A 5vooA-5cjuA:
3.1		 5vooA-5cjuA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 5 ASN A  44
ASP A  40
ASN A 743
ASP A 739
 None
B12  A1101 (-3.5A)
B12  A1101 ( 4.6A)
None
 1.27A 5vooC-5cjuA:
3.2		 5vooC-5cjuA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 5 ASN A  44
ASP A  40
ASN A 743
ASP A 739
 None
B12  A1101 (-3.5A)
B12  A1101 ( 4.6A)
None
 1.19A 5vooE-5cjuA:
8.1		 5vooE-5cjuA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		5 / 9 THR A 217
GLY A 218
ALA A 220
GLY A 313
GLU A 310
 None
GDP  A1104 ( 4.5A)
GDP  A1104 (-4.8A)
None
MG  A1105 (-3.2A)
 1.06A 5vw4A-5cjuA:
undetectable		 5vw4A-5cjuA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 5 HIS A1038
ALA A 655
SER A1074
GLY A1076
 None
 1.27A 5yodD-5cjuA:
undetectable		 5yodD-5cjuA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 6 ILE A 700
ALA A 717
ARG A 720
ASP A1068
 None
 1.12A 6hu9m-5cjuA:
undetectable
6hu9q-5cjuA:
undetectable		 6hu9m-5cjuA:
19.50
6hu9q-5cjuA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 5cju ISOBUTYRYL-COA
MUTASE FUSED
(Cupriavidus
metallidurans) 		4 / 6 THR A 656
LEU A 657
THR A 631
LEU A1066
 None
 1.20A 6mvxA-5cjuA:
undetectable
6mvxB-5cjuA:
undetectable
6mvxC-5cjuA:
undetectable		 6mvxA-5cjuA:
14.12
6mvxB-5cjuA:
14.12
6mvxC-5cjuA:
14.12