SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ck3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN
(Chaetomium
thermophilum) 		4 / 4 THR B 216
LEU B 220
VAL B 223
LEU B 227
 None
 0.72A 1fbmB-5ck3B:
undetectable		 1fbmB-5ck3B:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN
(Chaetomium
thermophilum) 		4 / 4 THR B 216
LEU B 220
VAL B 223
LEU B 227
 None
 0.90A 1mz9D-5ck3B:
undetectable		 1mz9D-5ck3B:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 LEU B  75
VAL B  83
GLY B  84
ASP B 133
 None
 0.71A 1p2yA-5ck3B:
undetectable		 1p2yA-5ck3B:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 LEU B  75
VAL B  83
GLY B  84
ASP B 133
 None
 0.71A 1t88A-5ck3B:
undetectable		 1t88A-5ck3B:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 GLY B 327
GLY B 326
LEU B 246
LEU B 199
LEU B 267
 None
 1.03A 1ya4A-5ck3B:
2.4		 1ya4A-5ck3B:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN
SRX DOMAIN
(Chaetomium
thermophilum) 		4 / 7 SER B 107
SER A  12
VAL A  14
LEU B 115
 GTP  B 402 ( 2.3A)
None
None
None
 0.80A 2hdnE-5ck3B:
undetectable
2hdnF-5ck3B:
6.4
2hdnH-5ck3B:
6.6		 2hdnE-5ck3B:
9.31
2hdnF-5ck3B:
20.98
2hdnH-5ck3B:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN
SRX DOMAIN
(Chaetomium
thermophilum) 		4 / 7 SER A  12
VAL A  14
LEU B 115
SER B 107
 None
None
None
GTP  B 402 ( 2.3A)
 0.81A 2hdnF-5ck3A:
undetectable
2hdnG-5ck3A:
undetectable
2hdnH-5ck3A:
undetectable		 2hdnF-5ck3A:
21.36
2hdnG-5ck3A:
21.33
2hdnH-5ck3A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 LEU B 254
TRP B 339
MET B 325
LEU B 200
 GTP  B 402 (-4.5A)
None
None
None
 1.06A 2oz7A-5ck3B:
undetectable		 2oz7A-5ck3B:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 PRO B  58
GLY B  60
ALA B  61
ALA B 202
 None
GTP  B 402 (-3.9A)
GTP  B 402 (-4.1A)
None
 0.85A 3ur0B-5ck3B:
undetectable		 3ur0B-5ck3B:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 PRO B  58
GLY B  60
ALA B  61
ALA B 203
 None
GTP  B 402 (-3.9A)
GTP  B 402 (-4.1A)
None
 0.57A 3ur0B-5ck3B:
undetectable		 3ur0B-5ck3B:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN
(Chaetomium
thermophilum) 		5 / 10 PHE B 310
SER B 307
LEU B 302
GLY B 303
ALA B  61
 None
None
None
None
GTP  B 402 (-4.1A)
 1.46A 4fe1A-5ck3B:
undetectable
4fe1J-5ck3B:
undetectable		 4fe1A-5ck3B:
19.10
4fe1J-5ck3B:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 ASP B 222
THR B 216
LEU B 302
GLN B 279
 None
 1.04A 4ib4A-5ck3B:
undetectable		 4ib4A-5ck3B:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN
(Chaetomium
thermophilum) 		4 / 5 VAL B 196
LEU B 161
ILE B  56
LEU B  55
 None
 0.82A 4mghA-5ck3B:
2.8		 4mghA-5ck3B:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ALA B 249
GLY B 335
ASP B 253
ALA B 336
TYR B 128
 None
None
GTP  B 402 (-3.3A)
None
None
 1.16A 4pclA-5ck3B:
2.2		 4pclA-5ck3B:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL B 130
LEU B  67
LEU B  69
LEU B 115
ALA B 336
 None
 1.22A 4x1kA-5ck3B:
undetectable
4x1kB-5ck3B:
3.5		 4x1kA-5ck3B:
23.72
4x1kB-5ck3B:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 ASP B 146
THR B 147
PRO B 110
SER B 107
 GTP  B 402 ( 4.7A)
None
None
GTP  B 402 ( 2.3A)
 1.19A 5b6iA-5ck3B:
undetectable		 5b6iA-5ck3B:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 ARG B 234
ARG B 238
ALA B 239
PRO B 240
 None
 1.19A 5odqA-5ck3B:
3.3		 5odqA-5ck3B:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 5ck3 SRX DOMAIN
PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN
(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		3 / 3 GLY A  13
LEU A   9
HIS B 105
 MG  B 401 ( 4.5A)
None
None
 0.69A 5u63A-5ck3A:
undetectable		 5u63A-5ck3A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 5ck3 SRX DOMAIN
(Chaetomium
thermophilum) 		5 / 12 ALA A 100
SER A 104
GLU A 108
LEU A 105
PHE A 110
 None
 1.39A 5vlmA-5ck3A:
undetectable		 5vlmA-5ck3A:
21.43