SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5clr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5clr LEGK4
(Legionella
pneumophila) 		4 / 7 LEU A  27
ILE A  36
ILE A  72
ASP A  96
 None
 0.87A 1uwjA-5clrA:
15.7		 1uwjA-5clrA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 5clr LEGK4
(Legionella
pneumophila) 		3 / 3 SER A 217
SER A 218
HIS A 187
 None
 0.76A 3mzeA-5clrA:
undetectable		 3mzeA-5clrA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5clr LEGK4
(Legionella
pneumophila) 		4 / 5 LEU A 123
THR A 145
GLU A 119
HIS A 193
 None
 1.30A 3n58C-5clrA:
undetectable		 3n58C-5clrA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 5clr LEGK4
(Legionella
pneumophila) 		4 / 5 TYR A 332
THR A 331
PHE A 330
LEU A 337
 None
 0.77A 3qelC-5clrA:
undetectable		 3qelC-5clrA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 5clr LEGK4
(Legionella
pneumophila) 		4 / 5 SER A 390
LYS A 387
ARG A 312
LEU A 316
 None
 1.44A 4xdtA-5clrA:
undetectable		 4xdtA-5clrA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5clr LEGK4
(Legionella
pneumophila) 		4 / 9 TYR A 364
ILE A 360
ILE A 356
LEU A 353
 None
 0.74A 5vkqB-5clrA:
2.4
5vkqC-5clrA:
2.4		 5vkqB-5clrA:
14.54
5vkqC-5clrA:
14.54