SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5clw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
5 / 12 LEU A 525
HIS A 528
LEU A 597
GLY A 531
PHE A 625
None
1.40A 1d4fC-5clwA:
undetectable
1d4fC-5clwA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
3 / 3 TRP A 548
ALA A 483
VAL A 485
None
0.95A 1w5uA-5clwA:
undetectable
1w5uB-5clwA:
undetectable
1w5uA-5clwA:
2.52
1w5uB-5clwA:
2.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
3 / 3 ALA A 483
VAL A 485
TRP A 548
None
0.94A 2izqA-5clwA:
undetectable
2izqB-5clwA:
undetectable
2izqA-5clwA:
2.52
2izqB-5clwA:
2.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
3 / 3 TRP A 548
ALA A 483
VAL A 485
None
0.89A 2izqC-5clwA:
undetectable
2izqD-5clwA:
undetectable
2izqC-5clwA:
2.52
2izqD-5clwA:
2.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
5 / 10 ILE A  55
ILE A  59
LEU A 395
ASN A 397
ILE A 424
None
1.15A 2nnhB-5clwA:
undetectable
2nnhB-5clwA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
4 / 8 ILE A 439
PHE A 616
GLY A 532
ILE A 474
None
0.94A 2qwxA-5clwA:
undetectable
2qwxB-5clwA:
undetectable
2qwxA-5clwA:
15.84
2qwxB-5clwA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
3 / 3 GLU A 271
HIS A 277
HIS A 188
None
0.91A 3co4A-5clwA:
4.7
3co4A-5clwA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
3 / 3 TYR A 200
ASP A 584
HIS A 545
None
0.95A 3e23A-5clwA:
undetectable
3e23A-5clwA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
5 / 12 LEU A 525
HIS A 528
LEU A 597
GLY A 531
PHE A 625
None
1.27A 3glqA-5clwA:
undetectable
3glqA-5clwA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
5 / 12 LEU A 525
HIS A 528
LEU A 597
GLY A 531
PHE A 625
None
1.27A 3glqB-5clwA:
undetectable
3glqB-5clwA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
3 / 3 TRP A 548
ALA A 483
VAL A 485
None
0.95A 3l8lA-5clwA:
undetectable
3l8lB-5clwA:
undetectable
3l8lA-5clwA:
2.52
3l8lB-5clwA:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
3 / 3 TRP A 548
ALA A 483
VAL A 485
None
0.89A 3l8lC-5clwA:
undetectable
3l8lD-5clwA:
undetectable
3l8lC-5clwA:
2.52
3l8lD-5clwA:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
4 / 5 TYR A 433
THR A 409
ARG A 355
LEU A 435
None
1.29A 3qelC-5clwA:
undetectable
3qelC-5clwA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
5 / 12 ARG A 226
PHE A 551
PHE A 249
PHE A 538
GLY A 540
None
0.97A 4e1gB-5clwA:
undetectable
4e1gB-5clwA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG5_A_MMZA616_1
(LACTOPEROXIDASE)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
4 / 5 GLN A 566
HIS A 545
ARG A 565
LEU A 569
None
1.47A 4ig5A-5clwA:
undetectable
4ig5A-5clwA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG5_B_MMZB617_1
(LACTOPEROXIDASE)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
4 / 5 GLN A 566
HIS A 545
ARG A 565
LEU A 569
None
1.47A 4ig5B-5clwA:
undetectable
4ig5B-5clwA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
5 / 12 VAL A 145
TYR A 155
PHE A 110
SER A 148
GLY A  97
None
1.33A 4mm4A-5clwA:
undetectable
4mm4A-5clwA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM7_A_29JA603_1
(TRANSPORTER)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
5 / 10 VAL A 145
TYR A 155
PHE A 110
SER A 148
GLY A  97
None
1.31A 4mm7A-5clwA:
undetectable
4mm7A-5clwA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
5 / 10 VAL A 145
TYR A 155
PHE A 110
SER A 148
GLY A  97
None
1.35A 4mmcA-5clwA:
undetectable
4mmcA-5clwA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
4 / 7 ASP A 274
THR A 275
PHE A 186
HIS A 188
None
1.46A 4o4dA-5clwA:
undetectable
4o4dA-5clwA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
4 / 7 PHE A 249
HIS A 203
ILE A 206
ASN A 541
None
1.31A 4o7gA-5clwA:
undetectable
4o7gB-5clwA:
undetectable
4o7gA-5clwA:
14.91
4o7gB-5clwA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
4 / 6 ASP A 286
ARG A 355
GLY A 358
HIS A 480
None
1.07A 4oltA-5clwA:
undetectable
4oltA-5clwA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
4 / 6 ASP A 286
ARG A 355
GLY A 358
HIS A 480
None
1.06A 4oltB-5clwA:
undetectable
4oltB-5clwA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
5 / 12 LEU A 525
HIS A 528
LEU A 597
GLY A 531
PHE A 625
None
1.24A 4pgfA-5clwA:
undetectable
4pgfA-5clwA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
3 / 3 GLN A 566
HIS A 545
ARG A 565
None
1.20A 4qyqA-5clwA:
undetectable
4qyqA-5clwA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
3 / 3 GLN A 566
HIS A 545
ARG A 565
None
1.18A 4qyqB-5clwA:
undetectable
4qyqB-5clwA:
20.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CLT_A_ACRA1000_1
(1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
10 / 10 ASN A  62
GLU A  63
TRP A  91
PRO A  93
TYR A 119
GLY A 120
LYS A 121
TRP A 332
GLU A 333
ARG A 336
GLC  A1004 ( 3.2A)
GLC  A1004 ( 3.4A)
GLC  A1006 ( 3.8A)
GLC  A1007 ( 4.0A)
GLC  A1005 ( 3.8A)
GLC  A1007 ( 3.7A)
GLC  A1005 ( 2.9A)
GLC  A1005 ( 4.8A)
GLC  A1005 ( 3.5A)
GLC  A1005 ( 4.3A)
0.32A 5cltA-5clwA:
64.8
5cltA-5clwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CLT_B_ACRB1000_1
(1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
10 / 10 ASN A  62
GLU A  63
TRP A  91
PRO A  93
TYR A 119
GLY A 120
LYS A 121
TRP A 332
GLU A 333
ARG A 336
GLC  A1004 ( 3.2A)
GLC  A1004 ( 3.4A)
GLC  A1006 ( 3.8A)
GLC  A1007 ( 4.0A)
GLC  A1005 ( 3.8A)
GLC  A1007 ( 3.7A)
GLC  A1005 ( 2.9A)
GLC  A1005 ( 4.8A)
GLC  A1005 ( 3.5A)
GLC  A1005 ( 4.3A)
0.36A 5cltB-5clwA:
67.0
5cltB-5clwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CLT_C_ACRC1000_1
(1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
10 / 10 ASN A  62
GLU A  63
TRP A  91
PRO A  93
TYR A 119
GLY A 120
LYS A 121
TRP A 332
GLU A 333
ARG A 336
GLC  A1004 ( 3.2A)
GLC  A1004 ( 3.4A)
GLC  A1006 ( 3.8A)
GLC  A1007 ( 4.0A)
GLC  A1005 ( 3.8A)
GLC  A1007 ( 3.7A)
GLC  A1005 ( 2.9A)
GLC  A1005 ( 4.8A)
GLC  A1005 ( 3.5A)
GLC  A1005 ( 4.3A)
0.29A 5cltC-5clwA:
66.1
5cltC-5clwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
3 / 3 ASP A 573
ARG A 226
ARG A 585
None
0.95A 5eajB-5clwA:
undetectable
5eajB-5clwA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FF1_A_MMZA601_1
(LACTOPEROXIDASE)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
4 / 5 GLN A 566
HIS A 545
ARG A 565
LEU A 569
None
1.45A 5ff1A-5clwA:
1.0
5ff1A-5clwA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FF1_A_MMZA602_1
(LACTOPEROXIDASE)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
4 / 5 GLN A 566
HIS A 545
ARG A 565
LEU A 569
None
1.45A 5ff1A-5clwA:
1.0
5ff1A-5clwA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FF1_B_MMZB601_1
(LACTOPEROXIDASE)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
4 / 5 GLN A 566
HIS A 545
ARG A 565
LEU A 569
None
1.45A 5ff1B-5clwA:
undetectable
5ff1B-5clwA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FF1_B_MMZB613_1
(LACTOPEROXIDASE)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
4 / 5 GLN A 566
HIS A 545
ARG A 565
LEU A 569
None
1.45A 5ff1B-5clwA:
undetectable
5ff1B-5clwA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
5 / 12 GLY A 358
TYR A 251
HIS A 480
ALA A 239
ILE A 410
None
1.13A 5igvA-5clwA:
2.4
5igvA-5clwA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
4 / 7 SER A 255
ILE A 176
ASP A 298
ASN A 170
None
0.93A 5n5dA-5clwA:
undetectable
5n5dA-5clwA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
4 / 5 ASP A 286
ILE A 206
PHE A 551
TYR A 251
None
1.08A 6a93B-5clwA:
undetectable
6a93B-5clwA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
5 / 12 LEU A 525
HIS A 528
LEU A 597
GLY A 531
PHE A 625
None
1.20A 6aphA-5clwA:
undetectable
6aphA-5clwA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_A_SAMA401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
5 / 12 HIS A 203
SER A 324
GLN A 252
VAL A 288
ASP A 286
None
1.25A 6bxlA-5clwA:
undetectable
6bxlA-5clwA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
5 / 12 HIS A 203
SER A 324
GLN A 252
VAL A 288
ASP A 286
None
1.38A 6bxlB-5clwA:
undetectable
6bxlB-5clwA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo
sapiens)
5 / 12 LEU A 663
THR A 640
VAL A 638
ALA A 692
TYR A 657
None
1.13A 6djzA-5clwA:
undetectable
6djzA-5clwA:
16.29