SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cm2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_2
(BILE ACID RECEPTOR)		 5cm2 TRNA
METHYLTRANSFERASE
TRNA
METHYLTRANSFERASE
ACTIVATOR SUBUNIT
(Yarrowia
lipolytica) 		4 / 5 MET M  47
ARG M  50
ILE Z 120
HIS Z 111
 None
 1.27A 1osvB-5cm2M:
undetectable		 1osvB-5cm2M:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 5cm2 TRNA
METHYLTRANSFERASE
(Yarrowia
lipolytica) 		5 / 12 GLY Z  66
SER Z  85
ALA Z 106
ILE Z 122
PHE Z 128
 None
 0.82A 1ve3A-5cm2Z:
17.7		 1ve3A-5cm2Z:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 5cm2 TRNA
METHYLTRANSFERASE
(Yarrowia
lipolytica) 		5 / 12 GLY Z  66
SER Z  85
ALA Z 106
ILE Z 122
PHE Z 128
 None
 0.86A 1ve3B-5cm2Z:
17.1		 1ve3B-5cm2Z:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 5cm2 TRNA
METHYLTRANSFERASE
(Yarrowia
lipolytica) 		5 / 12 GLY Z  64
GLY Z  66
GLY Z  68
ASP Z 105
PHE Z 128
 None
 0.72A 3ihtA-5cm2Z:
8.8		 3ihtA-5cm2Z:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5cm2 TRNA
METHYLTRANSFERASE
(Yarrowia
lipolytica) 		5 / 12 ILE Z  63
GLY Z  64
ASP Z  83
ILE Z 122
ALA Z 123
 None
 0.71A 3jb1A-5cm2Z:
6.7		 3jb1A-5cm2Z:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)		 5cm2 TRNA
METHYLTRANSFERASE
ACTIVATOR SUBUNIT
(Yarrowia
lipolytica) 		5 / 11 PHE M  23
LEU M   4
SER M   6
PHE M   8
ILE M  51
 None
 1.30A 3ko0C-5cm2M:
undetectable
3ko0D-5cm2M:
undetectable
3ko0E-5cm2M:
undetectable
3ko0F-5cm2M:
undetectable		 3ko0C-5cm2M:
27.61
3ko0D-5cm2M:
27.61
3ko0E-5cm2M:
27.61
3ko0F-5cm2M:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 5cm2 TRNA
METHYLTRANSFERASE
ACTIVATOR SUBUNIT
(Yarrowia
lipolytica) 		5 / 11 PHE M  23
LEU M   4
SER M   6
PHE M   8
ILE M  51
 None
 1.19A 3ko0Q-5cm2M:
undetectable
3ko0R-5cm2M:
undetectable
3ko0S-5cm2M:
undetectable
3ko0T-5cm2M:
undetectable		 3ko0Q-5cm2M:
27.61
3ko0R-5cm2M:
27.61
3ko0S-5cm2M:
27.61
3ko0T-5cm2M:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5cm2 TRNA
METHYLTRANSFERASE
(Yarrowia
lipolytica) 		3 / 3 GLY Z  66
ASP Z  83
ASP Z 105
 None
 0.36A 3ou7C-5cm2Z:
15.7		 3ou7C-5cm2Z:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5cm2 TRNA
METHYLTRANSFERASE
(Yarrowia
lipolytica) 		5 / 12 GLY Z  64
GLY Z  66
SER Z  85
ALA Z 106
VAL Z 124
 None
 0.76A 4htfA-5cm2Z:
16.1		 4htfA-5cm2Z:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5cm2 TRNA
METHYLTRANSFERASE
(Yarrowia
lipolytica) 		5 / 12 GLY Z  64
GLY Z  66
SER Z  85
ALA Z 106
VAL Z 124
 None
 0.72A 4htfB-5cm2Z:
15.3		 4htfB-5cm2Z:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5cm2 TRNA
METHYLTRANSFERASE
(Yarrowia
lipolytica) 		6 / 12 GLY Z  64
GLY Z  66
SER Z  85
ASP Z 105
ALA Z 106
HIS Z 127
 None
 1.10A 4krhA-5cm2Z:
15.7		 4krhA-5cm2Z:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 5cm2 TRNA
METHYLTRANSFERASE
(Yarrowia
lipolytica) 		5 / 11 LEU Z 145
VAL Z  61
ILE Z 120
SER Z 121
LEU Z  51
 None
 1.49A 4lhmA-5cm2Z:
undetectable		 4lhmA-5cm2Z:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 5cm2 TRNA
METHYLTRANSFERASE
(Yarrowia
lipolytica) 		5 / 12 GLY Z  64
GLY Z  66
SER Z  85
VAL Z 124
HIS Z 127
 None
 0.30A 4qdjA-5cm2Z:
16.6		 4qdjA-5cm2Z:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5cm2 TRNA
METHYLTRANSFERASE
(Yarrowia
lipolytica) 		5 / 12 GLY Z  64
GLY Z  66
SER Z  85
ILE Z 122
ARG Z 133
 None
 0.90A 4qtuB-5cm2Z:
15.1		 4qtuB-5cm2Z:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5cm2 TRNA
METHYLTRANSFERASE
(Yarrowia
lipolytica) 		5 / 12 GLY Z  64
GLY Z  66
SER Z  85
ILE Z 122
ARG Z 133
 None
 0.93A 4qtuD-5cm2Z:
15.8		 4qtuD-5cm2Z:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 5cm2 TRNA
METHYLTRANSFERASE
(Yarrowia
lipolytica) 		3 / 3 GLU Z 219
TYR Z  70
GLU Z  48
 None
 0.60A 4ryaA-5cm2Z:
undetectable		 4ryaA-5cm2Z:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 5cm2 TRNA
METHYLTRANSFERASE
(Yarrowia
lipolytica) 		4 / 7 ILE Z 141
LEU Z 145
ALA Z 227
ILE Z 153
 None
 0.85A 4y03A-5cm2Z:
undetectable		 4y03A-5cm2Z:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 5cm2 TRNA
METHYLTRANSFERASE
(Yarrowia
lipolytica) 		4 / 4 ASP Z  62
GLY Z  66
ASP Z  83
ASP Z 105
 None
 0.49A 5e72A-5cm2Z:
14.5		 5e72A-5cm2Z:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5cm2 TRNA
METHYLTRANSFERASE
ACTIVATOR SUBUNIT
TRNA
METHYLTRANSFERASE
(Yarrowia
lipolytica;
Yarrowia
lipolytica) 		5 / 12 ALA M  55
PRO Z 112
PHE M  23
GLY M  20
SER M  19
 None
 1.27A 5hfjB-5cm2M:
undetectable		 5hfjB-5cm2M:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5cm2 TRNA
METHYLTRANSFERASE
ACTIVATOR SUBUNIT
TRNA
METHYLTRANSFERASE
(Yarrowia
lipolytica;
Yarrowia
lipolytica) 		5 / 12 ALA M  55
PRO Z 112
PHE M  23
GLY M  20
SER M  19
 None
 1.29A 5hfjF-5cm2M:
undetectable		 5hfjF-5cm2M:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5cm2 TRNA
METHYLTRANSFERASE
TRNA
METHYLTRANSFERASE
ACTIVATOR SUBUNIT
(Yarrowia
lipolytica) 		4 / 5 ILE M 115
LEU M 123
HIS Z 111
VAL M   9
 None
 1.22A 5jmnB-5cm2M:
undetectable		 5jmnB-5cm2M:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 5cm2 TRNA
METHYLTRANSFERASE
(Yarrowia
lipolytica) 		5 / 12 GLY Z  64
GLY Z  66
SER Z  85
ASP Z 105
ALA Z 123
 None
 0.85A 5kpcB-5cm2Z:
12.9		 5kpcB-5cm2Z:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 5cm2 TRNA
METHYLTRANSFERASE
(Yarrowia
lipolytica) 		5 / 12 GLY Z  64
GLY Z  66
ASP Z  83
ILE Z 122
HIS Z 127
 None
 0.40A 5wy0A-5cm2Z:
13.5		 5wy0A-5cm2Z:
23.27