SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cm5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 5cm5 HYDROXYETHYLTHIAZOLE
KINASE
(Staphylococcus
aureus) 		5 / 12 LEU A  30
ILE A 196
ALA A 197
ALA A  55
VAL A  86
 None
 1.10A 1cbsA-5cm5A:
undetectable		 1cbsA-5cm5A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 5cm5 HYDROXYETHYLTHIAZOLE
KINASE
(Staphylococcus
aureus) 		5 / 12 LEU A  30
ILE A 196
ALA A 197
ALA A  55
VAL A  86
 None
 1.03A 2fr3A-5cm5A:
undetectable		 2fr3A-5cm5A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5cm5 HYDROXYETHYLTHIAZOLE
KINASE
(Staphylococcus
aureus) 		5 / 9 GLU A 209
ILE A 212
ILE A 259
GLU A 261
ILE A 173
 None
 1.02A 2j9dA-5cm5A:
undetectable
2j9dB-5cm5A:
undetectable
2j9dC-5cm5A:
undetectable		 2j9dA-5cm5A:
18.82
2j9dB-5cm5A:
18.82
2j9dC-5cm5A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5cm5 HYDROXYETHYLTHIAZOLE
KINASE
(Staphylococcus
aureus) 		5 / 9 GLU A 261
ILE A 173
GLU A 209
ILE A 212
ILE A 259
 None
 0.98A 2j9dA-5cm5A:
undetectable
2j9dB-5cm5A:
undetectable
2j9dC-5cm5A:
undetectable		 2j9dA-5cm5A:
18.82
2j9dB-5cm5A:
18.82
2j9dC-5cm5A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5cm5 HYDROXYETHYLTHIAZOLE
KINASE
(Staphylococcus
aureus) 		5 / 9 ILE A 259
GLU A 261
ILE A 173
GLU A 209
ILE A 212
 None
 1.02A 2j9dA-5cm5A:
undetectable
2j9dB-5cm5A:
undetectable
2j9dC-5cm5A:
undetectable		 2j9dA-5cm5A:
18.82
2j9dB-5cm5A:
18.82
2j9dC-5cm5A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_E_ACTE1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5cm5 HYDROXYETHYLTHIAZOLE
KINASE
(Staphylococcus
aureus) 		5 / 10 GLU A 209
ILE A 212
ILE A 259
GLU A 261
ILE A 173
 None
 1.01A 2j9dD-5cm5A:
undetectable
2j9dE-5cm5A:
undetectable
2j9dF-5cm5A:
undetectable		 2j9dD-5cm5A:
18.82
2j9dE-5cm5A:
18.82
2j9dF-5cm5A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_E_ACTE1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5cm5 HYDROXYETHYLTHIAZOLE
KINASE
(Staphylococcus
aureus) 		5 / 10 GLU A 261
ILE A 173
GLU A 209
ILE A 212
ILE A 259
 None
 1.00A 2j9dD-5cm5A:
undetectable
2j9dE-5cm5A:
undetectable
2j9dF-5cm5A:
undetectable		 2j9dD-5cm5A:
18.82
2j9dE-5cm5A:
18.82
2j9dF-5cm5A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_E_ACTE1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5cm5 HYDROXYETHYLTHIAZOLE
KINASE
(Staphylococcus
aureus) 		5 / 10 ILE A 259
GLU A 261
ILE A 173
GLU A 209
ILE A 212
 None
 1.00A 2j9dD-5cm5A:
undetectable
2j9dE-5cm5A:
undetectable
2j9dF-5cm5A:
undetectable		 2j9dD-5cm5A:
18.82
2j9dE-5cm5A:
18.82
2j9dF-5cm5A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_H_ACTH1113_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5cm5 HYDROXYETHYLTHIAZOLE
KINASE
(Staphylococcus
aureus) 		5 / 9 GLU A 209
ILE A 212
ILE A 259
GLU A 261
ILE A 173
 None
 0.99A 2j9dG-5cm5A:
undetectable
2j9dH-5cm5A:
undetectable
2j9dI-5cm5A:
0.6		 2j9dG-5cm5A:
18.82
2j9dH-5cm5A:
18.82
2j9dI-5cm5A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_H_ACTH1113_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5cm5 HYDROXYETHYLTHIAZOLE
KINASE
(Staphylococcus
aureus) 		5 / 9 GLU A 261
ILE A 173
GLU A 209
ILE A 212
ILE A 259
 None
 0.98A 2j9dG-5cm5A:
undetectable
2j9dH-5cm5A:
undetectable
2j9dI-5cm5A:
0.6		 2j9dG-5cm5A:
18.82
2j9dH-5cm5A:
18.82
2j9dI-5cm5A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_H_ACTH1113_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5cm5 HYDROXYETHYLTHIAZOLE
KINASE
(Staphylococcus
aureus) 		5 / 9 ILE A 259
GLU A 261
ILE A 173
GLU A 209
ILE A 212
 None
 1.00A 2j9dG-5cm5A:
undetectable
2j9dH-5cm5A:
undetectable
2j9dI-5cm5A:
0.6		 2j9dG-5cm5A:
18.82
2j9dH-5cm5A:
18.82
2j9dI-5cm5A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 5cm5 HYDROXYETHYLTHIAZOLE
KINASE
(Staphylococcus
aureus) 		5 / 12 ASN A  19
LEU A  63
LEU A 105
CYH A 190
THR A  26
 None
 1.41A 2oaxF-5cm5A:
undetectable		 2oaxF-5cm5A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 5cm5 HYDROXYETHYLTHIAZOLE
KINASE
(Staphylococcus
aureus) 		5 / 11 LEU A  30
LEU A 191
ARG A   8
ILE A   7
VAL A 217
 None
 1.28A 2qd3A-5cm5A:
3.2		 2qd3A-5cm5A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5cm5 HYDROXYETHYLTHIAZOLE
KINASE
(Staphylococcus
aureus) 		4 / 8 ILE A 212
ALA A 214
LEU A 192
ILE A 166
 None
 0.78A 2w9sE-5cm5A:
undetectable		 2w9sE-5cm5A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 5cm5 HYDROXYETHYLTHIAZOLE
KINASE
(Staphylococcus
aureus) 		5 / 12 PHE A 237
LEU A 182
ALA A 222
ALA A 225
THR A 244
 None
 1.17A 3cwkA-5cm5A:
undetectable		 3cwkA-5cm5A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5cm5 HYDROXYETHYLTHIAZOLE
KINASE
(Staphylococcus
aureus) 		4 / 5 LEU A 241
LEU A 191
GLY A 189
GLY A 187
 None
 0.74A 3si7C-5cm5A:
undetectable
3si7D-5cm5A:
undetectable		 3si7C-5cm5A:
22.91
3si7D-5cm5A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 5cm5 HYDROXYETHYLTHIAZOLE
KINASE
(Staphylococcus
aureus) 		5 / 11 ALA A 210
ILE A 196
GLY A 198
PRO A  84
THR A 204
 None
 1.03A 3spkA-5cm5A:
undetectable		 3spkA-5cm5A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5cm5 HYDROXYETHYLTHIAZOLE
KINASE
(Staphylococcus
aureus) 		5 / 12 CYH A 102
LEU A 106
THR A 160
VAL A  92
ILE A 121
 None
 1.18A 4x1yB-5cm5A:
3.2		 4x1yB-5cm5A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5cm5 HYDROXYETHYLTHIAZOLE
KINASE
(Staphylococcus
aureus) 		5 / 11 GLY A 187
LEU A 182
ALA A 222
PHE A  25
PHE A 218
 None
 1.39A 6qgbA-5cm5A:
2.5		 6qgbA-5cm5A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_B_BEZB802_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5cm5 HYDROXYETHYLTHIAZOLE
KINASE
(Staphylococcus
aureus) 		5 / 10 GLY A 187
LEU A 182
ALA A 222
PHE A  25
PHE A 218
 None
 1.35A 6qgbB-5cm5A:
2.5		 6qgbB-5cm5A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_D_BEZD701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5cm5 HYDROXYETHYLTHIAZOLE
KINASE
(Staphylococcus
aureus) 		5 / 10 GLY A 187
LEU A 182
ALA A 222
PHE A  25
PHE A 218
 None
 1.34A 6qgbD-5cm5A:
2.5		 6qgbD-5cm5A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5cm5 HYDROXYETHYLTHIAZOLE
KINASE
(Staphylococcus
aureus) 		5 / 11 GLY A 187
LEU A 182
ALA A 222
PHE A  25
PHE A 218
 None
 1.35A 6qgbE-5cm5A:
2.6		 6qgbE-5cm5A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_F_BEZF701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5cm5 HYDROXYETHYLTHIAZOLE
KINASE
(Staphylococcus
aureus) 		5 / 10 GLY A 187
LEU A 182
ALA A 222
PHE A  25
PHE A 218
 None
 1.39A 6qgbF-5cm5A:
2.7		 6qgbF-5cm5A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 5cm5 HYDROXYETHYLTHIAZOLE
KINASE
(Staphylococcus
aureus) 		5 / 12 LEU A 122
ILE A 145
GLY A 116
ILE A 157
ALA A 156
 None
 1.12A 6qyaB-5cm5A:
undetectable		 6qyaB-5cm5A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 5cm5 HYDROXYETHYLTHIAZOLE
KINASE
(Staphylococcus
aureus) 		5 / 12 LEU A 122
ILE A 145
GLY A 116
ILE A 157
ALA A 156
 None
 1.15A 6qyaD-5cm5A:
undetectable		 6qyaD-5cm5A:
21.52