SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cm6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Pseudoalteromona
s
atlantica) 		4 / 6 LEU A 216
TRP A 211
PHE A  43
TYR A  95
 None
None
PYR  A 401 ( 4.2A)
PYR  A 401 (-4.6A)
 1.30A 1ibgH-5cm6A:
undetectable		 1ibgH-5cm6A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Pseudoalteromona
s
atlantica) 		4 / 5 PHE A 157
GLY A 154
THR A 297
PHE A 298
 None
 1.32A 1icuC-5cm6A:
undetectable
1icuD-5cm6A:
undetectable		 1icuC-5cm6A:
19.51
1icuD-5cm6A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Pseudoalteromona
s
atlantica) 		4 / 5 PHE A 157
GLY A 154
THR A 297
PHE A 298
 None
 1.39A 1icvA-5cm6A:
undetectable
1icvB-5cm6A:
undetectable		 1icvA-5cm6A:
19.51
1icvB-5cm6A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J78_B_VDYB500_1
(VITAMIN D BINDING
PROTEIN)		 5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Pseudoalteromona
s
atlantica) 		5 / 10 GLU A 210
VAL A 212
PHE A  43
TYR A  96
LEU A  76
 NA  A 402 ( 3.2A)
PYR  A 401 ( 4.6A)
PYR  A 401 ( 4.2A)
PYR  A 401 (-4.3A)
None
 1.43A 1j78B-5cm6A:
0.9		 1j78B-5cm6A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Pseudoalteromona
s
atlantica) 		4 / 6 THR A 297
PHE A 298
PHE A 157
GLY A 154
 None
 1.17A 1kqbA-5cm6A:
undetectable
1kqbB-5cm6A:
undetectable		 1kqbA-5cm6A:
20.44
1kqbB-5cm6A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Pseudoalteromona
s
atlantica) 		3 / 3 TRP A 211
PHE A  43
TRP A  36
 None
PYR  A 401 ( 4.2A)
None
 1.29A 1r15C-5cm6A:
undetectable		 1r15C-5cm6A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Pseudoalteromona
s
atlantica) 		3 / 3 TRP A 211
PHE A  43
TRP A  36
 None
PYR  A 401 ( 4.2A)
None
 1.28A 1r15F-5cm6A:
undetectable		 1r15F-5cm6A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Pseudoalteromona
s
atlantica) 		3 / 3 TRP A 211
PHE A  43
TRP A  36
 None
PYR  A 401 ( 4.2A)
None
 1.28A 1r15G-5cm6A:
undetectable		 1r15G-5cm6A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Pseudoalteromona
s
atlantica) 		3 / 3 TRP A 211
PHE A  43
TRP A  36
 None
PYR  A 401 ( 4.2A)
None
 1.27A 1r15H-5cm6A:
undetectable		 1r15H-5cm6A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Pseudoalteromona
s
atlantica) 		3 / 3 SER A 194
GLU A  34
ASP A  45
 None
 0.91A 2avdB-5cm6A:
undetectable		 2avdB-5cm6A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Pseudoalteromona
s
atlantica) 		4 / 7 TYR A 229
THR A 238
THR A 149
SER A 215
 None
PYR  A 401 (-3.8A)
None
None
 1.21A 2fb2B-5cm6A:
undetectable		 2fb2B-5cm6A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Pseudoalteromona
s
atlantica) 		4 / 6 TRP A  36
GLY A  77
GLY A  90
GLN A 241
 None
 0.97A 2qx6A-5cm6A:
undetectable
2qx6B-5cm6A:
undetectable		 2qx6A-5cm6A:
22.22
2qx6B-5cm6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Pseudoalteromona
s
atlantica) 		4 / 4 THR A 109
VAL A 212
GLY A 232
THR A 231
 None
PYR  A 401 ( 4.6A)
None
None
 1.07A 3cflA-5cm6A:
1.7		 3cflA-5cm6A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Pseudoalteromona
s
atlantica) 		5 / 12 MET A  50
THR A 149
PHE A 242
ILE A  66
ALA A 195
 None
 1.11A 3nxuB-5cm6A:
undetectable		 3nxuB-5cm6A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Pseudoalteromona
s
atlantica) 		5 / 12 MET A  50
THR A 238
PHE A 242
ILE A  66
ALA A 195
 None
PYR  A 401 (-3.8A)
None
None
None
 1.15A 3nxuB-5cm6A:
undetectable		 3nxuB-5cm6A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Pseudoalteromona
s
atlantica) 		3 / 3 PHE A  43
SER A 215
SER A 275
 PYR  A 401 ( 4.2A)
None
None
 0.97A 3ufgB-5cm6A:
undetectable		 3ufgB-5cm6A:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MF6_A_BEZA303_0
(GLUTATHIONE
S-TRANSFERASE DOMAIN)		 5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Pseudoalteromona
s
atlantica) 		4 / 5 THR A 238
PHE A 123
ASN A 148
TYR A 120
 PYR  A 401 (-3.8A)
None
None
None
 1.44A 4mf6A-5cm6A:
undetectable		 4mf6A-5cm6A:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Pseudoalteromona
s
atlantica) 		5 / 12 PRO A 193
ARG A 173
ALA A 178
GLY A 179
LEU A 182
 None
PYR  A 401 (-2.9A)
None
None
None
 1.43A 4oadA-5cm6A:
undetectable		 4oadA-5cm6A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Pseudoalteromona
s
atlantica) 		5 / 12 GLY A 179
ALA A 178
VAL A 302
TRP A 233
GLN A 234
 None
 1.15A 4ryaA-5cm6A:
3.7		 4ryaA-5cm6A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Pseudoalteromona
s
atlantica) 		5 / 12 GLU A 180
ILE A 306
ALA A 305
VAL A 302
PHE A 298
 None
 1.11A 4u95B-5cm6A:
undetectable		 4u95B-5cm6A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJQ_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Pseudoalteromona
s
atlantica) 		5 / 12 MET A 243
ILE A  78
ARG A 173
GLU A 210
GLU A 235
 None
None
PYR  A 401 (-2.9A)
NA  A 402 ( 3.2A)
NA  A 402 ( 2.5A)
 1.34A 4zjqD-5cm6A:
undetectable		 4zjqD-5cm6A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E2I_A_DMEA605_1
(ACETYLCHOLINESTERASE)		 5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Pseudoalteromona
s
atlantica) 		4 / 6 TYR A 139
ASP A 101
TYR A 136
PHE A 106
 None
 1.38A 5e2iA-5cm6A:
undetectable		 5e2iA-5cm6A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Pseudoalteromona
s
atlantica) 		4 / 7 VAL A 244
LEU A 252
MET A  50
VAL A  54
 None
 0.93A 5e4dA-5cm6A:
undetectable
5e4dB-5cm6A:
undetectable		 5e4dA-5cm6A:
21.65
5e4dB-5cm6A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		 5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Pseudoalteromona
s
atlantica) 		5 / 10 THR A 238
GLY A 147
LEU A 240
TYR A  95
HIS A  91
 PYR  A 401 (-3.8A)
None
PYR  A 401 (-4.6A)
PYR  A 401 (-4.6A)
None
 1.26A 6gnfC-5cm6A:
undetectable		 6gnfC-5cm6A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		 5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Pseudoalteromona
s
atlantica) 		5 / 11 ASN A 279
ASP A 217
THR A 231
GLY A 232
GLU A 210
 None
None
None
None
NA  A 402 ( 3.2A)
 0.94A 6mb5A-5cm6A:
undetectable		 6mb5A-5cm6A:
14.29