SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cm8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 5cm8 RAS-RELATED PROTEIN
RAL-A
(Drosophila
melanogaster) 		5 / 12 VAL B  22
GLY B  23
LEU B  27
GLY B  18
VAL B 164
 None
 0.99A 1fduC-5cm8B:
6.1		 1fduC-5cm8B:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 5cm8 RAS-RELATED PROTEIN
RAL-A
(Drosophila
melanogaster) 		3 / 3 GLN B  69
TYR B  48
ARG B  49
 None
 0.92A 1gtbA-5cm8B:
undetectable		 1gtbA-5cm8B:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 5cm8 RAS-RELATED PROTEIN
RAL-A
(Drosophila
melanogaster) 		4 / 6 MET B 169
ARG B  49
PRO B 118
GLY B  83
 None
 1.46A 3aqiA-5cm8B:
2.5		 3aqiA-5cm8B:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB4_0
(FERROCHELATASE)		 5cm8 RAS-RELATED PROTEIN
RAL-A
(Drosophila
melanogaster) 		4 / 6 MET B 169
ARG B  49
PRO B 118
GLY B  83
 None
 1.49A 3aqiB-5cm8B:
3.6		 3aqiB-5cm8B:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 5cm8 RAS-RELATED PROTEIN
RAL-A
(Drosophila
melanogaster) 		4 / 7 ASP B  94
SER B  91
GLU B  70
ASP B  71
 None
 1.17A 3bc9A-5cm8B:
undetectable		 3bc9A-5cm8B:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_SALA601_1
(SALICYLATE-AMP
LIGASE)		 5cm8 RAS-RELATED PROTEIN
RAL-A
(Drosophila
melanogaster) 		5 / 9 GLY B  83
VAL B  14
GLY B  85
LEU B 168
LYS B 112
 None
 1.39A 5wm2A-5cm8B:
3.1		 5wm2A-5cm8B:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5cm8 RAS-RELATED PROTEIN
RAL-A
(Drosophila
melanogaster) 		3 / 3 LYS B  13
LEU B  11
ARG B  49
 None
 0.85A 5yw0A-5cm8B:
undetectable		 5yw0A-5cm8B:
24.76