SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cm9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2
(Mus
musculus) 		5 / 9 ALA A 138
GLU A 142
ARG A 191
ILE A 208
LEU A 163
 None
 1.47A 1ereA-5cm9A:
undetectable		 1ereA-5cm9A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2
(Mus
musculus) 		5 / 9 ALA A 138
GLU A 142
ARG A 191
ILE A 208
LEU A 163
 None
 1.47A 1ereB-5cm9A:
undetectable		 1ereB-5cm9A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2
(Mus
musculus) 		5 / 9 ALA A 138
GLU A 142
ARG A 191
ILE A 208
LEU A 163
 None
 1.49A 1ereC-5cm9A:
undetectable		 1ereC-5cm9A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2
(Mus
musculus) 		5 / 9 ALA A 138
GLU A 142
ARG A 191
ILE A 208
LEU A 163
 None
 1.48A 1ereD-5cm9A:
undetectable		 1ereD-5cm9A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2
(Mus
musculus) 		5 / 12 ALA A 234
LEU A 492
VAL A 241
THR A 309
LEU A 495
 None
 1.29A 1jipA-5cm9A:
undetectable		 1jipA-5cm9A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2
(Mus
musculus) 		4 / 6 ARG A 184
ASP A 139
LEU A 136
GLY A 135
 None
 0.91A 1n13H-5cm9A:
undetectable
1n13K-5cm9A:
undetectable		 1n13H-5cm9A:
12.68
1n13K-5cm9A:
6.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2
(Mus
musculus) 		4 / 7 ASP A 139
LEU A 136
GLY A 135
ARG A 184
 None
 0.91A 1n13G-5cm9A:
undetectable
1n13J-5cm9A:
undetectable		 1n13G-5cm9A:
6.87
1n13J-5cm9A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2
(Mus
musculus) 		4 / 5 SER A 356
SER A 360
PHE A 294
VAL A 301
 None
 1.04A 1oipA-5cm9A:
undetectable		 1oipA-5cm9A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2
(Mus
musculus) 		5 / 10 LEU A 492
ALA A 298
ALA A 300
LEU A 247
ASP A 255
 None
 1.24A 1rlbE-5cm9A:
undetectable		 1rlbE-5cm9A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2
(Mus
musculus) 		3 / 3 ALA A 308
VAL A 305
TRP A 335
 None
 0.70A 1tkqB-5cm9A:
undetectable		 1tkqB-5cm9A:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2
(Mus
musculus) 		5 / 11 SER A 164
VAL A 162
LEU A 105
LEU A 185
LEU A 141
 None
 1.29A 2a15A-5cm9A:
undetectable		 2a15A-5cm9A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2
(Mus
musculus) 		4 / 7 VAL A 162
LEU A 120
HIS A 103
THR A 109
 None
 0.91A 2f78A-5cm9A:
undetectable		 2f78A-5cm9A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2
(Mus
musculus) 		4 / 7 VAL A 162
LEU A 120
HIS A 103
THR A 109
 None
 0.92A 2f78B-5cm9A:
undetectable		 2f78B-5cm9A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2
(Mus
musculus) 		4 / 5 ILE A 160
LEU A 207
ALA A 159
PHE A 174
 None
 1.03A 2opxA-5cm9A:
undetectable		 2opxA-5cm9A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2
(Mus
musculus) 		4 / 8 ARG A 184
ASP A 139
LEU A 136
GLY A 135
 None
 0.86A 2qqdB-5cm9A:
undetectable
2qqdC-5cm9A:
undetectable		 2qqdB-5cm9A:
12.68
2qqdC-5cm9A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2
(Mus
musculus) 		5 / 12 VAL A 354
VAL A 239
ALA A 300
SER A 304
LEU A 331
 None
 1.01A 4m11B-5cm9A:
undetectable		 4m11B-5cm9A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2
(Mus
musculus) 		3 / 3 SER A 265
ARG A 125
HIS A 124
 None
 1.03A 4mjwA-5cm9A:
undetectable
4mjwB-5cm9A:
undetectable		 4mjwA-5cm9A:
22.71
4mjwB-5cm9A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2
(Mus
musculus) 		5 / 12 TYR A 431
ALA A 298
GLY A 433
SER A 349
SER A 350
 None
 1.20A 4mmdB-5cm9A:
0.8		 4mmdB-5cm9A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2
(Mus
musculus) 		5 / 12 VAL A 354
LEU A 358
VAL A 239
ALA A 300
SER A 304
 None
 0.95A 4o1zB-5cm9A:
undetectable		 4o1zB-5cm9A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2
(Mus
musculus) 		5 / 9 VAL A 305
LEU A 306
SER A 304
ALA A 357
LEU A 358
 None
 1.08A 4rs0A-5cm9A:
undetectable		 4rs0A-5cm9A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2
(Mus
musculus) 		5 / 11 LEU A 100
ARG A 102
LEU A 120
ALA A 132
LEU A 133
 None
 1.20A 4wg0H-5cm9A:
undetectable
4wg0I-5cm9A:
undetectable
4wg0J-5cm9A:
undetectable		 4wg0H-5cm9A:
3.19
4wg0I-5cm9A:
3.19
4wg0J-5cm9A:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2
(Mus
musculus) 		5 / 11 ALA A 132
LEU A 133
LEU A 120
LEU A 100
ARG A 102
 None
 1.19A 4wg0G-5cm9A:
undetectable
4wg0H-5cm9A:
undetectable
4wg0I-5cm9A:
undetectable		 4wg0G-5cm9A:
3.19
4wg0H-5cm9A:
3.19
4wg0I-5cm9A:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2
(Mus
musculus) 		5 / 11 ALA A 132
LEU A 133
LEU A 120
LEU A 100
ARG A 102
 None
 1.19A 4wg0I-5cm9A:
undetectable
4wg0J-5cm9A:
undetectable
4wg0K-5cm9A:
undetectable		 4wg0I-5cm9A:
3.19
4wg0J-5cm9A:
3.19
4wg0K-5cm9A:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2
(Mus
musculus) 		5 / 12 PHE A 174
LEU A 121
TRP A 166
LEU A 133
LEU A 105
 None
 1.16A 5iepA-5cm9A:
undetectable		 5iepA-5cm9A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2
(Mus
musculus) 		3 / 3 VAL A 318
ALA A 308
GLN A 502
 None
 0.69A 6gb9A-5cm9A:
undetectable		 6gb9A-5cm9A:
22.83