SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cma'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 5cma ANTIBODY CH8H9 FAB
HEAVY CHAIN
ANTIBODY CH8H9 FAB
LIGHT CHAIN
(Mus
musculus) 		8 / 12 TYR A  36
GLN A  89
LEU A  96
PHE A  98
ASN B  35
VAL B  37
ALA B  97
TRP B 108
 None
 0.69A 1h8sA-5cmaA:
21.6		 1h8sA-5cmaA:
39.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 5cma ANTIBODY CH8H9 FAB
LIGHT CHAIN
(Mus
musculus) 		4 / 7 LEU A 135
THR A 172
SER A 162
THR A 164
 None
 0.75A 1ictD-5cmaA:
3.7		 1ictD-5cmaA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5cma ANTIBODY CH8H9 FAB
HEAVY CHAIN
(Mus
musculus) 		5 / 7 GLY B  54
PRO B  53
THR B  58
ILE B  51
GLY B  56
 None
 1.04A 1usqA-5cmaB:
undetectable		 1usqA-5cmaB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5cma ANTIBODY CH8H9 FAB
HEAVY CHAIN
(Mus
musculus) 		4 / 6 GLY B  54
PRO B  53
ILE B  51
GLY B  56
 None
 0.74A 1usqB-5cmaB:
undetectable		 1usqB-5cmaB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5cma ANTIBODY CH8H9 FAB
HEAVY CHAIN
(Mus
musculus) 		4 / 6 GLY B  54
PRO B  53
ILE B  51
GLY B  56
 None
 0.74A 1usqC-5cmaB:
undetectable		 1usqC-5cmaB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5cma ANTIBODY CH8H9 FAB
HEAVY CHAIN
(Mus
musculus) 		4 / 6 GLY B  54
PRO B  53
ILE B  51
GLY B  56
 None
 0.75A 1usqD-5cmaB:
undetectable		 1usqD-5cmaB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5cma ANTIBODY CH8H9 FAB
HEAVY CHAIN
(Mus
musculus) 		4 / 6 GLY B  54
PRO B  53
ILE B  51
GLY B  56
 None
 0.74A 1usqE-5cmaB:
undetectable		 1usqE-5cmaB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5cma ANTIBODY CH8H9 FAB
HEAVY CHAIN
(Mus
musculus) 		4 / 6 GLY B  54
PRO B  53
ILE B  51
GLY B  56
 None
 0.83A 2jkjA-5cmaB:
undetectable		 2jkjA-5cmaB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5cma ANTIBODY CH8H9 FAB
HEAVY CHAIN
(Mus
musculus) 		4 / 6 GLY B  54
PRO B  53
ILE B  51
GLY B  56
 None
 0.83A 2jkjB-5cmaB:
undetectable		 2jkjB-5cmaB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5cma ANTIBODY CH8H9 FAB
HEAVY CHAIN
(Mus
musculus) 		4 / 6 GLY B  54
PRO B  53
ILE B  51
GLY B  56
 None
 0.83A 2jkjC-5cmaB:
undetectable		 2jkjC-5cmaB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5cma ANTIBODY CH8H9 FAB
HEAVY CHAIN
(Mus
musculus) 		5 / 7 GLY B  54
PRO B  53
THR B  58
ILE B  51
GLY B  56
 None
 1.06A 2jklA-5cmaB:
undetectable		 2jklA-5cmaB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5cma ANTIBODY CH8H9 FAB
HEAVY CHAIN
(Mus
musculus) 		4 / 6 GLY B  54
PRO B  53
ILE B  51
GLY B  56
 None
 0.80A 2jklB-5cmaB:
undetectable		 2jklB-5cmaB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5cma ANTIBODY CH8H9 FAB
HEAVY CHAIN
(Mus
musculus) 		5 / 7 GLY B  54
PRO B  53
THR B  58
ILE B  51
GLY B  56
 None
 1.06A 2jklC-5cmaB:
undetectable		 2jklC-5cmaB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5cma ANTIBODY CH8H9 FAB
HEAVY CHAIN
(Mus
musculus) 		5 / 7 GLY B  54
PRO B  53
THR B  58
ILE B  51
GLY B  56
 None
 1.05A 2jklD-5cmaB:
undetectable		 2jklD-5cmaB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5cma ANTIBODY CH8H9 FAB
HEAVY CHAIN
(Mus
musculus) 		5 / 7 GLY B  54
PRO B  53
THR B  58
ILE B  51
GLY B  56
 None
 1.06A 2jklF-5cmaB:
undetectable		 2jklF-5cmaB:
19.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 5cma ANTIBODY CH8H9 FAB
LIGHT CHAIN
(Mus
musculus) 		4 / 5 TYR A  36
GLN A  89
LEU A  96
PHE A  98
 None
 0.46A 3ls4L-5cmaA:
26.4		 3ls4L-5cmaA:
60.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M7K_H_ACTH302_0
(10H10 HEAVY CHAIN)		 5cma ANTIBODY CH8H9 FAB
HEAVY CHAIN
(Mus
musculus) 		4 / 5 VAL B   2
TYR B  27
ARG B  98
TYR B 107
 None
 0.31A 4m7kH-5cmaB:
29.2		 4m7kH-5cmaB:
86.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 5cma ANTIBODY CH8H9 FAB
HEAVY CHAIN
(Mus
musculus) 		5 / 12 ALA B  16
PHE B 151
TYR B 150
LEU B 113
THR B  87
 None
 1.11A 5tl8A-5cmaB:
undetectable		 5tl8A-5cmaB:
18.52