SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cmc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 5cmc ML032222A IGLUR
(Mnemiopsis
leidyi) 		5 / 12 ASP A  60
ARG A 144
ILE A  88
LEU A  92
ILE A  77
 None
GLY  A 301 (-3.0A)
None
GLY  A 301 ( 4.7A)
None
 1.13A 1d1gB-5cmcA:
undetectable		 1d1gB-5cmcA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 5cmc ML032222A IGLUR
(Mnemiopsis
leidyi) 		5 / 12 PHE A  20
SER A  14
MET A  41
ILE A 241
LEU A 232
 None
 1.16A 1lhuA-5cmcA:
undetectable		 1lhuA-5cmcA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5cmc ML032222A IGLUR
(Mnemiopsis
leidyi) 		4 / 5 ASP A 187
LEU A 150
ALA A 115
LEU A 192
 None
 1.14A 1nh8A-5cmcA:
6.5		 1nh8A-5cmcA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 5cmc ML032222A IGLUR
(Mnemiopsis
leidyi) 		4 / 5 ILE A 241
PHE A  20
VAL A 116
PHE A 212
 None
 0.96A 2ygnA-5cmcA:
undetectable		 2ygnA-5cmcA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 5cmc ML032222A IGLUR
(Mnemiopsis
leidyi) 		4 / 5 PHE A  20
PRO A 107
VAL A 116
PHE A 212
 None
 1.11A 2ygnA-5cmcA:
undetectable		 2ygnA-5cmcA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5cmc ML032222A IGLUR
(Mnemiopsis
leidyi) 		5 / 12 ILE A 186
VAL A 140
GLY A 165
LEU A 131
LEU A 124
 None
 0.96A 3em0B-5cmcA:
undetectable		 3em0B-5cmcA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 5cmc ML032222A IGLUR
(Mnemiopsis
leidyi) 		5 / 9 ASN A  31
VAL A  42
GLY A  13
ILE A  56
THR A  52
 None
 1.16A 3spkA-5cmcA:
undetectable		 3spkA-5cmcA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 5cmc ML032222A IGLUR
(Mnemiopsis
leidyi) 		3 / 3 ASP A 187
TRP A 245
SER A  17
 None
 0.95A 4lrhB-5cmcA:
undetectable		 4lrhB-5cmcA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 5cmc ML032222A IGLUR
(Mnemiopsis
leidyi) 		3 / 3 ASP A 187
TRP A 245
SER A  17
 None
 0.93A 4lrhF-5cmcA:
undetectable		 4lrhF-5cmcA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5cmc ML032222A IGLUR
(Mnemiopsis
leidyi) 		5 / 12 GLY A 142
GLY A  64
ALA A  65
ILE A  90
SER A  14
 None
 1.04A 4rtmA-5cmcA:
undetectable		 4rtmA-5cmcA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 5cmc ML032222A IGLUR
(Mnemiopsis
leidyi) 		4 / 5 LEU A 131
ASP A 132
TYR A 158
LEU A 161
 None
 1.18A 4wozF-5cmcA:
undetectable
4wozH-5cmcA:
undetectable		 4wozF-5cmcA:
20.06
4wozH-5cmcA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 5cmc ML032222A IGLUR
(Mnemiopsis
leidyi) 		5 / 12 ASP A 229
LEU A 232
LEU A  45
LEU A 227
ILE A 228
 None
 1.11A 4x1fA-5cmcA:
undetectable		 4x1fA-5cmcA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 5cmc ML032222A IGLUR
(Mnemiopsis
leidyi) 		5 / 12 ASP A 229
LEU A 232
LEU A  45
LEU A 227
ILE A 228
 None
 1.13A 4x1gA-5cmcA:
undetectable		 4x1gA-5cmcA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5cmc ML032222A IGLUR
(Mnemiopsis
leidyi) 		4 / 5 TYR A 104
SER A 100
ALA A  97
THR A 148
 None
 1.34A 5n0wB-5cmcA:
undetectable		 5n0wB-5cmcA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5cmc ML032222A IGLUR
(Mnemiopsis
leidyi) 		4 / 5 TYR A 104
SER A 100
ALA A  97
THR A 148
 None
 1.37A 5n4iA-5cmcA:
undetectable		 5n4iA-5cmcA:
19.86