SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cml'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 5cml OSMC FAMILY PROTEIN
(Rhodothermus
marinus) 		5 / 11 LEU A 193
ALA A 248
LEU A  54
GLU A 242
VAL A 222
 None
 1.23A 1ictA-5cmlA:
undetectable
1ictC-5cmlA:
undetectable		 1ictA-5cmlA:
18.42
1ictC-5cmlA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 5cml OSMC FAMILY PROTEIN
(Rhodothermus
marinus) 		5 / 12 GLY A 132
VAL A 240
LEU A 224
LEU A 230
PHE A  34
 None
 1.07A 1mx1F-5cmlA:
12.9		 1mx1F-5cmlA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 5cml OSMC FAMILY PROTEIN
(Rhodothermus
marinus) 		4 / 8 ILE A 106
LEU A 104
LYS A   1
GLY A  58
 None
 1.02A 1os6A-5cmlA:
undetectable		 1os6A-5cmlA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 5cml OSMC FAMILY PROTEIN
(Rhodothermus
marinus) 		5 / 11 LEU A  54
VAL A 252
GLY A 253
ALA A  30
LEU A 104
 None
 1.26A 2bxgA-5cmlA:
undetectable		 2bxgA-5cmlA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5cml OSMC FAMILY PROTEIN
(Rhodothermus
marinus) 		5 / 12 ALA A 117
ARG A 141
THR A  83
LEU A 144
LEU A 110
 None
 1.04A 3k2hA-5cmlA:
undetectable		 3k2hA-5cmlA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 5cml OSMC FAMILY PROTEIN
(Rhodothermus
marinus) 		4 / 8 ILE A 106
LEU A 104
LYS A   1
GLY A  58
 None
 1.05A 3selX-5cmlA:
undetectable		 3selX-5cmlA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5cml OSMC FAMILY PROTEIN
(Rhodothermus
marinus) 		5 / 12 LEU A 244
VAL A 240
ALA A 227
PHE A  38
VAL A  47
 None
 1.09A 4ib4A-5cmlA:
undetectable		 4ib4A-5cmlA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 5cml OSMC FAMILY PROTEIN
(Rhodothermus
marinus) 		6 / 12 LEU A 244
VAL A 240
LEU A 230
ILE A  50
ILE A 106
ALA A  35
 None
 1.36A 4ltwA-5cmlA:
undetectable		 4ltwA-5cmlA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 5cml OSMC FAMILY PROTEIN
(Rhodothermus
marinus) 		3 / 3 ARG A  63
HIS A  36
SER A  51
 None
 0.98A 4mjwA-5cmlA:
undetectable
4mjwB-5cmlA:
undetectable		 4mjwA-5cmlA:
18.69
4mjwB-5cmlA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 5cml OSMC FAMILY PROTEIN
(Rhodothermus
marinus) 		3 / 3 SER A  51
ARG A  63
HIS A  36
 None
 1.02A 4mjwA-5cmlA:
undetectable
4mjwB-5cmlA:
undetectable		 4mjwA-5cmlA:
18.69
4mjwB-5cmlA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5cml OSMC FAMILY PROTEIN
(Rhodothermus
marinus) 		5 / 12 LEU A 244
VAL A 240
ALA A 227
PHE A  38
VAL A  47
 None
 1.08A 4nc3A-5cmlA:
undetectable		 4nc3A-5cmlA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5cml OSMC FAMILY PROTEIN
(Rhodothermus
marinus) 		5 / 9 ALA A 127
ILE A  50
VAL A 240
GLY A 245
SER A 220
 None
 1.31A 4r20B-5cmlA:
undetectable		 4r20B-5cmlA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 5cml OSMC FAMILY PROTEIN
(Rhodothermus
marinus) 		4 / 7 LEU A 104
LEU A 193
LEU A 192
ILE A 131
 None
 0.75A 4ubsA-5cmlA:
undetectable		 4ubsA-5cmlA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5cml OSMC FAMILY PROTEIN
(Rhodothermus
marinus) 		4 / 7 PHE A  34
ILE A 106
PHE A  38
LEU A 224
 None
 0.81A 4zdzA-5cmlA:
undetectable		 4zdzA-5cmlA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5cml OSMC FAMILY PROTEIN
(Rhodothermus
marinus) 		4 / 7 PHE A  34
ILE A 106
PHE A  38
LEU A 224
 None
 0.71A 4ze3A-5cmlA:
undetectable		 4ze3A-5cmlA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5cml OSMC FAMILY PROTEIN
(Rhodothermus
marinus) 		5 / 12 VAL A 179
GLU A 175
LEU A 116
ALA A 117
ARG A  89
 None
 1.24A 5nd4B-5cmlA:
4.5		 5nd4B-5cmlA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 5cml OSMC FAMILY PROTEIN
(Rhodothermus
marinus) 		5 / 12 ALA A  35
GLY A 111
GLU A 174
LEU A 176
GLU A 177
 None
 1.25A 5nwuA-5cmlA:
undetectable		 5nwuA-5cmlA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 5cml OSMC FAMILY PROTEIN
(Rhodothermus
marinus) 		4 / 5 LEU A 244
PHE A 239
PHE A 195
LEU A 193
 None
 1.11A 5x1bP-5cmlA:
undetectable		 5x1bP-5cmlA:
22.26