SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cmn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5cmn LATROPHILIN-3
(Homo
sapiens) 		4 / 5 THR E 179
GLU E 223
THR E 225
HIS E 204
 None
 1.48A 1d4fD-5cmnE:
undetectable		 1d4fD-5cmnE:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 5cmn LATROPHILIN-3
(Homo
sapiens) 		3 / 3 TRP E 379
VAL E 367
TRP E 158
 None
CA  E 401 (-4.8A)
None
 0.77A 1gmkC-5cmnE:
undetectable
1gmkD-5cmnE:
undetectable		 1gmkC-5cmnE:
4.23
1gmkD-5cmnE:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5cmn LATROPHILIN-3
(Homo
sapiens) 		5 / 12 TYR E 143
ALA E 366
ILE E 364
LEU E 139
PHE E 357
 None
 1.26A 1udtA-5cmnE:
undetectable		 1udtA-5cmnE:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 5cmn LATROPHILIN-3
(Homo
sapiens) 		5 / 10 TYR E 363
GLY E 208
GLY E 156
ALA E 365
ALA E 366
 None
 1.04A 2ej3B-5cmnE:
undetectable		 2ej3B-5cmnE:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 5cmn LATROPHILIN-3
(Homo
sapiens) 		4 / 8 ILE E 169
TRP E 158
PHE E 149
TYR E 185
 None
 1.27A 3ccfB-5cmnE:
undetectable		 3ccfB-5cmnE:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 5cmn LATROPHILIN-3
(Homo
sapiens) 		5 / 11 ALA E 266
GLY E 318
ILE E 319
ILE E 285
ILE E 275
 None
 0.83A 3ebzA-5cmnE:
undetectable		 3ebzA-5cmnE:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M8P_A_65BA562_0
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 5cmn LATROPHILIN-3
(Homo
sapiens) 		5 / 11 LEU E 376
VAL E 355
VAL E 323
TYR E 321
LEU E 389
 None
 1.22A 3m8pA-5cmnE:
undetectable
3m8pB-5cmnE:
undetectable		 3m8pA-5cmnE:
17.54
3m8pB-5cmnE:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 5cmn LATROPHILIN-3
(Homo
sapiens) 		5 / 9 ALA E 266
GLY E 318
ILE E 319
ILE E 285
ILE E 275
 None
 0.69A 3s43A-5cmnE:
undetectable		 3s43A-5cmnE:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 5cmn LATROPHILIN-3
(Homo
sapiens) 		5 / 9 ALA E 266
GLY E 318
ILE E 319
ILE E 285
ILE E 275
 None
 0.80A 3s45A-5cmnE:
undetectable		 3s45A-5cmnE:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 5cmn LATROPHILIN-3
(Homo
sapiens) 		5 / 11 ALA E 266
GLY E 318
ILE E 319
ILE E 285
ILE E 275
 None
 0.74A 3s53B-5cmnE:
undetectable		 3s53B-5cmnE:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 5cmn LATROPHILIN-3
(Homo
sapiens) 		3 / 3 TRP E 379
VAL E 367
TRP E 158
 None
CA  E 401 (-4.8A)
None
 1.16A 3zq8C-5cmnE:
undetectable
3zq8D-5cmnE:
undetectable		 3zq8C-5cmnE:
4.23
3zq8D-5cmnE:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5cmn LATROPHILIN-3
(Homo
sapiens) 		4 / 8 PHE E 314
VAL E 367
ILE E 364
ASN E 312
 None
CA  E 401 (-4.8A)
None
CA  E 401 (-3.3A)
 1.01A 4a97C-5cmnE:
undetectable		 4a97C-5cmnE:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5cmn LATROPHILIN-3
(Homo
sapiens) 		4 / 8 PHE E 314
VAL E 367
ILE E 364
ASN E 312
 None
CA  E 401 (-4.8A)
None
CA  E 401 (-3.3A)
 1.02A 4a97G-5cmnE:
undetectable		 4a97G-5cmnE:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 5cmn LATROPHILIN-3
(Homo
sapiens) 		5 / 12 LEU E 233
GLY E 216
TYR E 214
TYR E 200
LEU E 182
 None
 1.37A 5czyA-5cmnE:
undetectable		 5czyA-5cmnE:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 5cmn LATROPHILIN-3
(Homo
sapiens) 		5 / 12 ALA E 266
GLY E 318
ILE E 319
ILE E 285
ILE E 275
 None
 0.74A 5e5jA-5cmnE:
undetectable		 5e5jA-5cmnE:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 5cmn LATROPHILIN-3
(Homo
sapiens) 		5 / 12 ALA E 266
GLY E 318
ILE E 319
ILE E 285
ILE E 275
 None
 0.75A 5e5kB-5cmnE:
undetectable		 5e5kB-5cmnE:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5cmn LATROPHILIN-3
(Homo
sapiens) 		4 / 4 ASN E 312
SER E 155
ALA E 366
VAL E 378
 CA  E 401 (-3.3A)
None
None
None
 1.40A 5nm5A-5cmnE:
undetectable		 5nm5A-5cmnE:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 5cmn LATROPHILIN-3
(Homo
sapiens) 		5 / 12 LEU E 376
VAL E 355
VAL E 323
TYR E 321
LEU E 389
 None
 1.32A 6eliA-5cmnE:
undetectable		 6eliA-5cmnE:
13.48