SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cni'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A  62
PHE A  38
LEU A  26
ILE A 378
VAL A 385
 None
 1.16A 1hrkA-5cniA:
3.5		 1hrkA-5cniA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A  62
PHE A  38
LEU A  26
ILE A 378
VAL A 385
 None
 1.15A 1hrkB-5cniA:
3.9		 1hrkB-5cniA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 10 ILE A  88
GLY A  35
GLU A  29
GLY A  30
ARG A  83
 None
 1.24A 1mehA-5cniA:
undetectable		 1mehA-5cniA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 11 SER A 212
LEU A 278
VAL A 254
VAL A 210
THR A 270
 None
 1.31A 1q23F-5cniA:
undetectable		 1q23F-5cniA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_A_STRA301_1
(MINERALOCORTICOID
RECEPTOR)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A 155
ALA A 152
GLN A 162
SER A 148
LEU A  37
 None
 1.40A 2aa5A-5cniA:
undetectable		 2aa5A-5cniA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A 155
ALA A 152
GLN A 162
SER A 148
LEU A  37
 None
 1.39A 2aa5B-5cniA:
undetectable		 2aa5B-5cniA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A  62
PHE A  38
LEU A  26
ILE A 378
VAL A 385
 None
 1.15A 2hrcA-5cniA:
2.9		 2hrcA-5cniA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A  62
PHE A  38
LEU A  26
ILE A 378
VAL A 385
 None
 1.10A 2hrcB-5cniA:
4.7		 2hrcB-5cniA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_2
(PROTEASE)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 9 LEU A  79
GLY A  85
ASP A  70
ILE A 140
ILE A  72
 None
 0.94A 2idwB-5cniA:
undetectable		 2idwB-5cniA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 PHE A 432
TYR A 386
ALA A 389
ALA A  86
GLY A  30
 None
 1.08A 2igtA-5cniA:
3.6		 2igtA-5cniA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A  62
PHE A  38
LEU A  26
ILE A 378
VAL A 385
 None
 1.21A 2po7A-5cniA:
undetectable		 2po7A-5cniA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		4 / 8 ARG A 183
SER A 173
ASP A 444
ALA A 170
 None
 1.32A 2rk8A-5cniA:
undetectable		 2rk8A-5cniA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		4 / 7 GLN A 191
MET A 195
ILE A 317
SER A 376
 None
 1.21A 2xytI-5cniA:
undetectable		 2xytI-5cniA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		4 / 8 TYR A 468
GLN A 191
ILE A 317
SER A 376
 None
 1.08A 2xz5B-5cniA:
undetectable
2xz5E-5cniA:
undetectable		 2xz5B-5cniA:
17.94
2xz5E-5cniA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 THR A 237
GLU A 239
LEU A 278
ALA A 287
PHE A 289
 None
 1.50A 3apxA-5cniA:
undetectable		 3apxA-5cniA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A  62
PHE A  38
LEU A  26
ILE A 378
VAL A 385
 None
 1.16A 3aqiB-5cniA:
2.8		 3aqiB-5cniA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 9 TYR A 458
THR A 316
TYR A 468
GLY A 296
ALA A 275
 None
None
None
GGL  A 601 ( 4.3A)
None
 1.13A 3jusB-5cniA:
undetectable		 3jusB-5cniA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 10 ALA A 293
LEU A 279
VAL A 303
TYR A 216
THR A 316
 None
None
None
GGL  A 601 (-4.0A)
None
 1.09A 3jw3A-5cniA:
3.7		 3jw3A-5cniA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		4 / 6 GLN A 191
MET A 195
ILE A 317
SER A 376
 None
 1.13A 3pmzD-5cniA:
undetectable		 3pmzD-5cniA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 ALA A  98
LEU A 154
ILE A 136
GLY A  35
HIS A  87
 None
 0.90A 3q95A-5cniA:
undetectable		 3q95A-5cniA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A  99
ALA A  98
ILE A 136
GLY A  35
HIS A  87
 None
 1.00A 3q95B-5cniA:
undetectable		 3q95B-5cniA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		4 / 8 ASP A 188
ASP A 295
GLY A 296
ARG A  61
 None
GGL  A 601 (-3.0A)
GGL  A 601 ( 4.3A)
GGL  A 601 (-2.9A)
 0.98A 3s3nA-5cniA:
2.2		 3s3nA-5cniA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A  62
PHE A  38
LEU A  26
ILE A 378
VAL A 385
 None
 1.15A 3w1wA-5cniA:
4.0		 3w1wA-5cniA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A  62
PHE A  38
LEU A  26
ILE A 378
VAL A 385
 None
 1.15A 3w1wB-5cniA:
3.0		 3w1wB-5cniA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		4 / 7 MET A 195
ILE A 221
VAL A 265
TRP A 204
 None
 1.29A 4f4dA-5cniA:
6.4		 4f4dA-5cniA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		3 / 3 PRO A  39
TYR A 144
GLY A 142
 CL  A 602 ( 4.0A)
None
CL  A 602 ( 4.1A)
 0.73A 4g2zA-5cniA:
undetectable		 4g2zA-5cniA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PL1_A_SAMA401_0
(DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 11 PHE A 181
PRO A  39
SER A 167
ILE A 149
ASN A 153
 None
CL  A 602 ( 4.0A)
GGL  A 601 (-4.5A)
None
None
 1.37A 4pl1A-5cniA:
1.6		 4pl1A-5cniA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 11 LEU A  99
ALA A  98
ILE A 136
GLY A  35
HIS A  87
 None
 0.98A 4pxmB-5cniA:
undetectable		 4pxmB-5cniA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 9 LEU A  79
GLY A  85
ASP A  70
ILE A 140
ILE A  72
 None
 0.92A 4rvjB-5cniA:
undetectable		 4rvjB-5cniA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 9 LEU A  79
GLY A  85
ASP A  70
ILE A 140
ILE A  72
 None
 0.92A 4rvjD-5cniA:
undetectable		 4rvjD-5cniA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		4 / 6 GLY A 217
GLU A 218
ASP A 274
ASP A 295
 None
None
None
GGL  A 601 (-3.0A)
 1.06A 4uckB-5cniA:
undetectable		 4uckB-5cniA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 ALA A 166
SER A 143
GLU A 318
GLY A 298
GLN A  60
 GGL  A 601 (-3.8A)
CL  A 602 ( 4.1A)
GGL  A 601 ( 4.9A)
None
None
 1.13A 4uilH-5cniA:
undetectable
4uilL-5cniA:
undetectable		 4uilH-5cniA:
17.14
4uilL-5cniA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP9_C_1WEC706_1
(TRANSPORTER)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		4 / 4 PHE A 269
ASP A 295
GLY A 220
SER A 294
 None
GGL  A 601 (-3.0A)
None
None
 1.42A 4xp9C-5cniA:
undetectable		 4xp9C-5cniA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		4 / 8 ASP A 146
ASP A  95
GLU A 100
ASP A  49
 None
 1.06A 5cfsA-5cniA:
undetectable		 5cfsA-5cniA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 10 ALA A 293
ALA A 275
VAL A 303
VAL A 304
TYR A 468
 None
 0.88A 5eb5B-5cniA:
undetectable		 5eb5B-5cniA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 VAL A 413
LEU A 406
ALA A 108
GLY A 138
LEU A 392
 None
 1.07A 5jw1A-5cniA:
undetectable		 5jw1A-5cniA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		6 / 12 THR A 270
GLU A 218
GLY A 214
TYR A 216
ILE A 149
ASP A  95
 None
None
None
GGL  A 601 (-4.0A)
None
None
 1.41A 5kvaA-5cniA:
3.3		 5kvaA-5cniA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		4 / 6 TYR A 216
THR A 168
ASP A 215
GLY A 214
 GGL  A 601 (-4.0A)
GGL  A 601 (-3.0A)
None
None
 1.22A 5mraA-5cniA:
0.9
5mraB-5cniA:
0.8		 5mraA-5cniA:
14.69
5mraB-5cniA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		4 / 7 GLN A 162
GLY A 142
GLN A 191
ASP A  95
 None
CL  A 602 ( 4.1A)
None
None
 1.16A 5vlmE-5cniA:
undetectable		 5vlmE-5cniA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		3 / 3 HIS A 390
HIS A 393
ARG A 397
 None
 0.98A 6b58A-5cniA:
2.2		 6b58A-5cniA:
23.65