SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cnx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5cnx AMINOPEPTIDASE YPDF
(Escherichia
coli) 		5 / 12 VAL A  81
TRP A  10
ILE A  42
ALA A  18
LEU A  93
 None
 1.03A 1eqhA-5cnxA:
undetectable		 1eqhA-5cnxA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5cnx AMINOPEPTIDASE YPDF
(Escherichia
coli) 		5 / 12 VAL A  81
TRP A  10
ILE A  42
ALA A  18
LEU A  93
 None
 1.04A 1eqhB-5cnxA:
undetectable		 1eqhB-5cnxA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 5cnx AMINOPEPTIDASE YPDF
(Escherichia
coli) 		5 / 11 LEU A 193
GLY A 191
GLY A 331
VAL A 245
LEU A 242
 None
 1.02A 1mx1A-5cnxA:
undetectable		 1mx1A-5cnxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ULV_A_ACRA3000_2
(GLUCODEXTRANASE)		 5cnx AMINOPEPTIDASE YPDF
(Escherichia
coli) 		4 / 5 GLN A  99
GLU A  96
LEU A   7
TRP A  10
 None
 1.35A 1ulvA-5cnxA:
undetectable		 1ulvA-5cnxA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 5cnx AMINOPEPTIDASE YPDF
(Escherichia
coli) 		3 / 3 MET A 224
VAL A 347
GLU A 321
 None
None
ZN  A 401 ( 2.3A)
 0.89A 3c6gA-5cnxA:
undetectable		 3c6gA-5cnxA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5cnx AMINOPEPTIDASE YPDF
(Escherichia
coli) 		4 / 5 LEU A 124
GLN A  14
HIS A  30
LEU A  21
 None
 1.19A 3ce6D-5cnxA:
undetectable		 3ce6D-5cnxA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 5cnx AMINOPEPTIDASE YPDF
(Escherichia
coli) 		5 / 12 ALA A 119
LEU A  11
LEU A  16
LEU A  93
HIS A  30
 None
 1.11A 3erdA-5cnxA:
undetectable		 3erdA-5cnxA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5cnx AMINOPEPTIDASE YPDF
(Escherichia
coli) 		5 / 12 GLN A 109
GLY A  94
ALA A  18
LEU A  77
ILE A  84
 NA  A 405 (-3.9A)
None
None
None
None
 1.16A 4hytA-5cnxA:
undetectable		 4hytA-5cnxA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5cnx AMINOPEPTIDASE YPDF
(Escherichia
coli) 		5 / 12 GLN A 109
GLY A  94
ALA A  18
LEU A  77
ILE A  84
 NA  A 405 (-3.9A)
None
None
None
None
 1.16A 4hytC-5cnxA:
2.2		 4hytC-5cnxA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 5cnx AMINOPEPTIDASE YPDF
(Escherichia
coli) 		3 / 3 VAL A 100
SER A 101
THR A 104
 None
 0.36A 4luhA-5cnxA:
undetectable		 4luhA-5cnxA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5cnx AMINOPEPTIDASE YPDF
(Escherichia
coli) 		5 / 12 ALA A 293
ILE A 294
ASN A  26
GLY A 219
GLN A  28
 None
 1.13A 4r38B-5cnxA:
undetectable		 4r38B-5cnxA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5cnx AMINOPEPTIDASE YPDF
(Escherichia
coli) 		5 / 12 ALA A 293
ILE A 294
ASN A  26
GLY A 219
GLN A  28
 None
 1.14A 4r38C-5cnxA:
undetectable		 4r38C-5cnxA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5cnx AMINOPEPTIDASE YPDF
(Escherichia
coli) 		5 / 12 ALA A 293
ILE A 294
ASN A  26
GLY A 219
GLN A  28
 None
 1.12A 4r38D-5cnxA:
undetectable		 4r38D-5cnxA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 5cnx AMINOPEPTIDASE YPDF
(Escherichia
coli) 		5 / 9 PRO A 194
GLY A 330
ILE A 184
VAL A 332
THR A 210
 None
 1.37A 4x3mA-5cnxA:
undetectable		 4x3mA-5cnxA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 5cnx AMINOPEPTIDASE YPDF
(Escherichia
coli) 		5 / 12 ALA A 119
LEU A  11
LEU A  16
LEU A  93
HIS A  30
 None
 1.14A 4zn7A-5cnxA:
undetectable		 4zn7A-5cnxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 5cnx AMINOPEPTIDASE YPDF
(Escherichia
coli) 		4 / 6 LEU A  20
LEU A  11
LEU A  16
LEU A  90
 None
 0.93A 5gs4A-5cnxA:
undetectable		 5gs4A-5cnxA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 5cnx AMINOPEPTIDASE YPDF
(Escherichia
coli) 		3 / 3 GLY A 295
GLN A  28
LYS A 128
 None
 0.91A 5imsB-5cnxA:
undetectable		 5imsB-5cnxA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5cnx AMINOPEPTIDASE YPDF
(Escherichia
coli) 		3 / 3 ASP A 301
ASN A  26
GLN A  25
 None
 0.82A 5k7uA-5cnxA:
undetectable		 5k7uA-5cnxA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 5cnx AMINOPEPTIDASE YPDF
(Escherichia
coli) 		4 / 7 GLY A 291
HIS A 292
ASP A 223
HIS A 195
 None
ZN  A 401 (-3.3A)
ZN  A 402 (-2.5A)
CAC  A 403 (-4.1A)
 0.88A 5nnwD-5cnxA:
undetectable		 5nnwD-5cnxA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 5cnx AMINOPEPTIDASE YPDF
(Escherichia
coli) 		4 / 7 GLY A 291
HIS A 292
ASP A 223
HIS A 195
 None
ZN  A 401 (-3.3A)
ZN  A 402 (-2.5A)
CAC  A 403 (-4.1A)
 0.90A 5no9D-5cnxA:
undetectable		 5no9D-5cnxA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5cnx AMINOPEPTIDASE YPDF
(Escherichia
coli) 		4 / 8 PHE A 304
ARG A 261
ILE A 260
GLY A 344
 None
 0.98A 5nzxA-5cnxA:
undetectable		 5nzxA-5cnxA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5cnx AMINOPEPTIDASE YPDF
(Escherichia
coli) 		3 / 3 GLY A 359
VAL A 203
MET A 158
 None
 0.59A 5ycpA-5cnxA:
undetectable		 5ycpA-5cnxA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 5cnx AMINOPEPTIDASE YPDF
(Escherichia
coli) 		4 / 4 LEU A 318
ASP A 301
PRO A 302
ARG A 303
 None
 0.98A 6fgdA-5cnxA:
undetectable		 6fgdA-5cnxA:
23.79