SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5co4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_2
(HMG-COA REDUCTASE)
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Thermus
thermophilus)
5 / 11 GLU B 110
SER B  80
LEU B 107
ALA B  78
LEU B  99
None
1.00A 1hwkB-5co4B:
undetectable
1hwkB-5co4B:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_B_117B1_1
(HMG-COA REDUCTASE)
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Thermus
thermophilus)
5 / 11 GLU B 110
SER B  80
LEU B 107
ALA B  78
LEU B  99
None
0.99A 1hwkA-5co4B:
undetectable
1hwkA-5co4B:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_2
(HMG-COA REDUCTASE)
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Thermus
thermophilus)
5 / 11 GLU B 110
SER B  80
LEU B 107
ALA B  78
LEU B  99
None
0.97A 1hwkD-5co4B:
undetectable
1hwkD-5co4B:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_1
(HMG-COA REDUCTASE)
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Thermus
thermophilus)
5 / 11 GLU B 110
SER B  80
LEU B 107
ALA B  78
LEU B  99
None
0.98A 1hwkC-5co4B:
undetectable
1hwkC-5co4B:
16.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Thermus
thermophilus)
5 / 12 GLY B 106
LYS B 119
ILE B 120
MET B 122
LEU B 129
MTA  B 401 (-3.2A)
None
MTA  B 401 (-3.7A)
MTA  B 401 (-3.4A)
MTA  B 401 (-4.3A)
0.77A 1v2xA-5co4B:
17.7
1v2xA-5co4B:
33.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Thermus
thermophilus)
9 / 12 PHE B 100
GLY B 101
GLY B 106
LYS B 119
ILE B 120
MET B 122
SER B 128
LEU B 129
ALA B 134
MTA  B 401 (-4.9A)
MTA  B 401 (-3.2A)
MTA  B 401 (-3.2A)
None
MTA  B 401 (-3.7A)
MTA  B 401 (-3.4A)
MTA  B 401 ( 3.9A)
MTA  B 401 (-4.3A)
MTA  B 401 (-3.5A)
0.56A 1v2xA-5co4B:
17.7
1v2xA-5co4B:
33.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Thermus
thermophilus)
7 / 11 GLY B 101
GLY B 106
ILE B 120
MET B 122
SER B 128
LEU B 129
ALA B 134
MTA  B 401 (-3.2A)
MTA  B 401 (-3.2A)
MTA  B 401 (-3.7A)
MTA  B 401 (-3.4A)
MTA  B 401 ( 3.9A)
MTA  B 401 (-4.3A)
MTA  B 401 (-3.5A)
0.77A 1x7pA-5co4B:
19.4
1x7pB-5co4B:
19.6
1x7pA-5co4B:
26.07
1x7pB-5co4B:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Thermus
thermophilus)
6 / 10 GLY B 101
GLY B 106
ILE B 120
MET B 122
LEU B 129
ALA B 134
MTA  B 401 (-3.2A)
MTA  B 401 (-3.2A)
MTA  B 401 (-3.7A)
MTA  B 401 (-3.4A)
MTA  B 401 (-4.3A)
MTA  B 401 (-3.5A)
0.56A 1x7pA-5co4B:
19.4
1x7pB-5co4B:
19.6
1x7pA-5co4B:
26.07
1x7pB-5co4B:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Thermus
thermophilus)
5 / 12 LEU B   6
LEU B 131
GLY B  16
ALA B  19
ALA B  23
None
MTA  B 401 ( 4.2A)
None
None
None
1.18A 2br4E-5co4B:
2.7
2br4E-5co4B:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Thermus
thermophilus)
6 / 11 ALA B  81
GLY B 101
GLY B 106
ILE B 120
LEU B 129
ALA B 134
MTA  B 401 (-3.7A)
MTA  B 401 (-3.2A)
MTA  B 401 (-3.2A)
MTA  B 401 (-3.7A)
MTA  B 401 (-4.3A)
MTA  B 401 (-3.5A)
0.53A 3dcmX-5co4B:
14.0
3dcmX-5co4B:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Thermus
thermophilus)
6 / 12 ALA B  81
GLY B 101
ILE B 120
MET B 122
SER B 128
LEU B 129
MTA  B 401 (-3.7A)
MTA  B 401 (-3.2A)
MTA  B 401 (-3.7A)
MTA  B 401 (-3.4A)
MTA  B 401 ( 3.9A)
MTA  B 401 (-4.3A)
0.64A 3gyqA-5co4B:
17.2
3gyqB-5co4B:
17.1
3gyqA-5co4B:
21.22
3gyqB-5co4B:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Thermus
thermophilus)
6 / 11 ALA B  81
GLY B 101
ILE B 120
MET B 122
SER B 128
LEU B 129
MTA  B 401 (-3.7A)
MTA  B 401 (-3.2A)
MTA  B 401 (-3.7A)
MTA  B 401 (-3.4A)
MTA  B 401 ( 3.9A)
MTA  B 401 (-4.3A)
0.39A 3gyqB-5co4B:
17.1
3gyqB-5co4B:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Thermus
thermophilus)
6 / 12 ASN B  14
GLY B 101
GLY B 106
ILE B 120
MET B 122
ASN B 130
None
MTA  B 401 (-3.2A)
MTA  B 401 (-3.2A)
MTA  B 401 (-3.7A)
MTA  B 401 (-3.4A)
None
0.49A 3nk7A-5co4B:
17.6
3nk7A-5co4B:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Thermus
thermophilus)
6 / 12 ASN B  14
GLY B 101
ILE B 120
MET B 122
SER B 128
ASN B 130
None
MTA  B 401 (-3.2A)
MTA  B 401 (-3.7A)
MTA  B 401 (-3.4A)
MTA  B 401 ( 3.9A)
None
0.43A 3nk7A-5co4B:
17.6
3nk7A-5co4B:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Thermus
thermophilus)
6 / 12 ASN B  14
GLY B 106
ILE B 120
MET B 122
SER B 128
LEU B 129
None
MTA  B 401 (-3.2A)
MTA  B 401 (-3.7A)
MTA  B 401 (-3.4A)
MTA  B 401 ( 3.9A)
MTA  B 401 (-4.3A)
1.21A 3nk7B-5co4B:
17.5
3nk7B-5co4B:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Thermus
thermophilus)
8 / 12 ASN B  14
PHE B 100
GLY B 101
GLY B 106
ILE B 120
MET B 122
SER B 128
LEU B 129
None
MTA  B 401 (-4.9A)
MTA  B 401 (-3.2A)
MTA  B 401 (-3.2A)
MTA  B 401 (-3.7A)
MTA  B 401 (-3.4A)
MTA  B 401 ( 3.9A)
MTA  B 401 (-4.3A)
0.62A 3nk7B-5co4B:
17.5
3nk7B-5co4B:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Thermus
thermophilus)
5 / 9 GLY B 101
GLU B 103
ILE B 120
MET B 122
SER B 128
MTA  B 401 (-3.2A)
MTA  B 401 (-4.3A)
MTA  B 401 (-3.7A)
MTA  B 401 (-3.4A)
MTA  B 401 ( 3.9A)
0.62A 4x3mA-5co4B:
19.1
4x3mA-5co4B:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Thermus
thermophilus)
5 / 9 GLY B 101
ILE B 120
MET B 122
SER B 128
LEU B 129
MTA  B 401 (-3.2A)
MTA  B 401 (-3.7A)
MTA  B 401 (-3.4A)
MTA  B 401 ( 3.9A)
MTA  B 401 (-4.3A)
0.55A 4x3mB-5co4B:
18.0
4x3mB-5co4B:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Thermus
thermophilus)
5 / 12 ILE B 120
GLY B 136
THR B  21
LEU B   4
HIS B   3
MTA  B 401 (-3.7A)
None
None
None
None
1.28A 5esgA-5co4B:
undetectable
5esgA-5co4B:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Thermus
thermophilus)
6 / 12 LEU B  98
LEU B 107
ALA B  90
GLY B 136
ALA B 134
LEU B 131
None
None
None
None
MTA  B 401 (-3.5A)
MTA  B 401 ( 4.2A)
1.30A 5jw1B-5co4B:
undetectable
5jw1B-5co4B:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Thermus
thermophilus)
7 / 12 GLY B 101
GLY B 106
ILE B 120
SER B 128
LEU B 129
LEU B 131
ALA B 134
MTA  B 401 (-3.2A)
MTA  B 401 (-3.2A)
MTA  B 401 (-3.7A)
MTA  B 401 ( 3.9A)
MTA  B 401 (-4.3A)
MTA  B 401 ( 4.2A)
MTA  B 401 (-3.5A)
0.47A 5l0zA-5co4B:
20.0
5l0zA-5co4B:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Thermus
thermophilus)
7 / 10 GLY B 101
GLY B 106
ILE B 120
SER B 128
LEU B 129
LEU B 131
ALA B 134
MTA  B 401 (-3.2A)
MTA  B 401 (-3.2A)
MTA  B 401 (-3.7A)
MTA  B 401 ( 3.9A)
MTA  B 401 (-4.3A)
MTA  B 401 ( 4.2A)
MTA  B 401 (-3.5A)
0.44A 5l0zB-5co4B:
8.0
5l0zB-5co4B:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Thermus
thermophilus)
5 / 10 GLY B 101
GLU B 103
GLY B 106
LEU B 129
ALA B 134
MTA  B 401 (-3.2A)
MTA  B 401 (-4.3A)
MTA  B 401 (-3.2A)
MTA  B 401 (-4.3A)
MTA  B 401 (-3.5A)
0.81A 5o96C-5co4B:
13.3
5o96D-5co4B:
13.0
5o96C-5co4B:
19.59
5o96D-5co4B:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Thermus
thermophilus)
5 / 10 GLY B 101
GLU B 103
GLY B 106
LEU B 129
ALA B 134
MTA  B 401 (-3.2A)
MTA  B 401 (-4.3A)
MTA  B 401 (-3.2A)
MTA  B 401 (-4.3A)
MTA  B 401 (-3.5A)
0.87A 5o96E-5co4B:
9.6
5o96F-5co4B:
11.0
5o96E-5co4B:
19.59
5o96F-5co4B:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Thermus
thermophilus)
5 / 12 ILE B  32
LEU B   6
LEU B  70
ALA B 138
GLY B 136
None
1.10A 5uxdB-5co4B:
undetectable
5uxdB-5co4B:
24.75