SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5co8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 5co8 NUCLEASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 PRO A 206
GLY A 207
CYH A 208
LEU A 244
 None
 0.70A 1h4oG-5co8A:
undetectable		 1h4oG-5co8A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 5co8 NUCLEASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ILE A 107
PHE A 110
THR A 310
LEU A 306
PHE A  61
 None
 1.17A 1og5B-5co8A:
undetectable		 1og5B-5co8A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5co8 NUCLEASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 PHE A  76
ILE A  75
GLU A 122
LEU A 138
VAL A 134
 None
None
MG  A 501 ( 2.6A)
None
None
 1.20A 3fpjB-5co8A:
3.7		 3fpjB-5co8A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5co8 NUCLEASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 LEU A 325
LEU A 109
ILE A 303
GLY A 305
ALA A 304
 None
 1.08A 3n8zB-5co8A:
undetectable		 3n8zB-5co8A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 5co8 NUCLEASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 LYS A   8
GLY A 209
ALA A 213
ALA A 217
LEU A 191
 None
 1.05A 3p5nA-5co8A:
undetectable		 3p5nA-5co8A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5co8 NUCLEASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 LYS A 449
GLU A 445
TRP A 459
 None
 1.01A 3v4tH-5co8A:
undetectable		 3v4tH-5co8A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 5co8 NUCLEASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 HIS A 168
GLU A 379
ASP A 375
GLU A  27
 None
 1.26A 3vywA-5co8A:
undetectable		 3vywA-5co8A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5co8 NUCLEASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 PRO A  32
LEU A 339
LEU A  68
ILE A  72
PHE A 110
 None
 1.42A 4a79B-5co8A:
undetectable		 4a79B-5co8A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 5co8 NUCLEASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 PRO A 269
TYR A 276
GLU A 272
TYR A 277
 None
 1.05A 4lb2A-5co8A:
undetectable		 4lb2A-5co8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 5co8 NUCLEASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 LYS A   2
ARG A 154
HIS A 172
 None
 1.26A 4zbrA-5co8A:
2.2		 4zbrA-5co8A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 5co8 NUCLEASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 11 LEU A 138
ALA A 136
LEU A  21
LEU A  33
LEU A 171
 None
 1.31A 4zn7B-5co8A:
undetectable		 4zn7B-5co8A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 5co8 NUCLEASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 5 PHE A 295
HIS A  25
LEU A  35
PRO A 296
 None
 1.25A 5csyB-5co8A:
undetectable		 5csyB-5co8A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5co8 NUCLEASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 SER A  17
THR A 374
PRO A 444
ILE A 447
 None
 1.25A 5vkqA-5co8A:
undetectable
5vkqB-5co8A:
undetectable		 5vkqA-5co8A:
14.57
5vkqB-5co8A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5co8 NUCLEASE-LIKE
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 ARG A 341
LEU A 361
PHE A 384
 None
 0.58A 6nknP-5co8A:
undetectable		 6nknP-5co8A:
18.50