SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5coc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 5coc IMMUNOGLOBULIN
G-BINDING PROTEIN
A,CALMODULIN
(Homo
sapiens;
Staphylococcus
aureus) 		8 / 11 PHE A1020
ILE A1028
LEU A1033
MET A1037
LEU A1040
MET A1052
VAL A1056
MET A1072
 None
 0.55A 1dtlA-5cocA:
12.6		 1dtlA-5cocA:
40.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 5coc IMMUNOGLOBULIN
G-BINDING PROTEIN
A,CALMODULIN
(Homo
sapiens;
Staphylococcus
aureus) 		4 / 8 MET A1037
GLN A1042
PRO A1044
GLU A1048
 None
 0.91A 1dtlA-5cocA:
12.6		 1dtlA-5cocA:
40.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LIN_A_TFPA155_1
(CALMODULIN)		 5coc IMMUNOGLOBULIN
G-BINDING PROTEIN
A,CALMODULIN
(Homo
sapiens;
Staphylococcus
aureus) 		4 / 7 PHE A1020
MET A1072
MET A1073
ALA A1074
 None
 1.31A 1linA-5cocA:
13.2		 1linA-5cocA:
57.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5coc IMMUNOGLOBULIN
G-BINDING PROTEIN
A,CALMODULIN
(Homo
sapiens;
Staphylococcus
aureus) 		7 / 12 PHE A1020
ILE A1028
LEU A1033
MET A1037
MET A1052
ILE A1053
GLU A1055
 None
 1.08A 1lxfC-5cocA:
9.2		 1lxfC-5cocA:
40.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRK_A_TFPA202_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5coc IMMUNOGLOBULIN
G-BINDING PROTEIN
A,CALMODULIN
(Homo
sapiens;
Staphylococcus
aureus) 		5 / 10 MET A1037
LEU A1040
GLN A1042
GLU A1048
MET A1052
 None
 0.86A 1wrkA-5cocA:
10.8
1wrkB-5cocA:
10.8		 1wrkA-5cocA:
40.60
1wrkB-5cocA:
40.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_C_TFPC206_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5coc IMMUNOGLOBULIN
G-BINDING PROTEIN
A,CALMODULIN
(Homo
sapiens;
Staphylococcus
aureus) 		5 / 9 MET A1037
LEU A1040
GLN A1042
GLU A1048
MET A1052
 None
 0.80A 1wrlC-5cocA:
10.8
1wrlD-5cocA:
10.8		 1wrlC-5cocA:
40.60
1wrlD-5cocA:
40.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WRL_E_TFPE210_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5coc IMMUNOGLOBULIN
G-BINDING PROTEIN
A,CALMODULIN
(Homo
sapiens;
Staphylococcus
aureus) 		5 / 9 MET A1037
LEU A1040
GLN A1042
GLU A1048
MET A1052
 None
 0.75A 1wrlE-5cocA:
10.9
1wrlF-5cocA:
10.7		 1wrlE-5cocA:
40.60
1wrlF-5cocA:
40.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRI_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 5coc IMMUNOGLOBULIN
G-BINDING PROTEIN
A,CALMODULIN
(Homo
sapiens;
Staphylococcus
aureus) 		5 / 10 LEU A1070
ARG A1075
THR A1027
ASP A1021
PHE A1013
 None
None
None
CA  A1102 (-3.4A)
None
 1.44A 4driB-5cocA:
0.3		 4driB-5cocA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 5coc IMMUNOGLOBULIN
G-BINDING PROTEIN
A,CALMODULIN
(Homo
sapiens;
Staphylococcus
aureus) 		4 / 6 ASP A1059
ASP A1057
ASN A1054
ASP A1065
 CA  A1101 (-2.9A)
CA  A1101 (-3.1A)
None
CA  A1101 ( 4.1A)
 1.16A 4mdaA-5cocA:
undetectable		 4mdaA-5cocA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_A_TFPA203_1
(CALMODULIN)		 5coc IMMUNOGLOBULIN
G-BINDING PROTEIN
A,CALMODULIN
(Homo
sapiens;
Staphylococcus
aureus) 		4 / 8 PHE A1020
ILE A1028
LEU A1033
MET A1052
 None
 0.57A 4rjdA-5cocA:
12.7		 4rjdA-5cocA:
27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_A_TFPA203_1
(CALMODULIN)		 5coc IMMUNOGLOBULIN
G-BINDING PROTEIN
A,CALMODULIN
(Homo
sapiens;
Staphylococcus
aureus) 		4 / 8 PHE A1020
ILE A1028
LEU A1033
MET A1072
 None
 0.70A 4rjdA-5cocA:
12.7		 4rjdA-5cocA:
27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB203_1
(CALMODULIN)		 5coc IMMUNOGLOBULIN
G-BINDING PROTEIN
A,CALMODULIN
(Homo
sapiens;
Staphylococcus
aureus) 		4 / 7 PHE A1020
LEU A1033
MET A1052
MET A1072
 None
 0.76A 4rjdB-5cocA:
12.6		 4rjdB-5cocA:
27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB203_1
(CALMODULIN)		 5coc IMMUNOGLOBULIN
G-BINDING PROTEIN
A,CALMODULIN
(Homo
sapiens;
Staphylococcus
aureus) 		4 / 7 PHE A1020
LEU A1033
MET A1052
MET A1072
 None
 1.03A 4rjdB-5cocA:
12.6		 4rjdB-5cocA:
27.50