SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5com'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5com PUTATIVE CONJUGATIVE
TRANSPOSON PROTEIN
TN1549-LIKE,
CTN5-ORF2
(Clostridioides
difficile) 		4 / 8 LEU A  68
VAL A  82
TRP A 100
LEU A  97
 None
 0.90A 4pwdC-5comA:
undetectable		 4pwdC-5comA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5com PUTATIVE CONJUGATIVE
TRANSPOSON PROTEIN
TN1549-LIKE,
CTN5-ORF2
(Clostridioides
difficile) 		4 / 8 LEU A  68
VAL A  82
TRP A 100
LEU A  97
 None
 0.94A 4q0bA-5comA:
undetectable		 4q0bA-5comA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5com PUTATIVE CONJUGATIVE
TRANSPOSON PROTEIN
TN1549-LIKE,
CTN5-ORF2
(Clostridioides
difficile) 		5 / 11 VAL A 156
ILE A 160
ASN A 163
THR A 164
ILE A 128
 None
None
TAR  A 201 (-2.3A)
None
None
 1.15A 5y80A-5comA:
undetectable		 5y80A-5comA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 5com PUTATIVE CONJUGATIVE
TRANSPOSON PROTEIN
TN1549-LIKE,
CTN5-ORF2
(Clostridioides
difficile) 		4 / 4 ARG A  77
GLU A  73
GLU A 135
ARG A 142
 None
 1.22A 6fk2A-5comA:
undetectable		 6fk2A-5comA:
17.49