SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cov'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 5cov NAEGLERIA GRUBERI
RNA LIGASE
(Naegleria
gruberi) 		3 / 3 ASP A 183
GLU A 193
ARG A 207
 None
 0.88A 1wopA-5covA:
undetectable		 1wopA-5covA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 5cov NAEGLERIA GRUBERI
RNA LIGASE
(Naegleria
gruberi) 		5 / 12 GLU A 193
ALA A 206
GLY A 186
ILE A 212
ILE A 253
 None
 1.11A 1x1aA-5covA:
undetectable		 1x1aA-5covA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 5cov NAEGLERIA GRUBERI
RNA LIGASE
(Naegleria
gruberi) 		4 / 6 ILE A 328
PRO A 124
ILE A 233
VAL A 281
 None
 0.93A 3n3iA-5covA:
undetectable		 3n3iA-5covA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 5cov NAEGLERIA GRUBERI
RNA LIGASE
(Naegleria
gruberi) 		6 / 12 GLU A 227
PHE A 248
VAL A 281
VAL A 315
LYS A 317
LYS A 326
 MN  A 401 ( 4.5A)
None
None
None
None
None
 0.60A 3qwuA-5covA:
13.9		 3qwuA-5covA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_B_ADNB501_1
(DNA LIGASE)		 5cov NAEGLERIA GRUBERI
RNA LIGASE
(Naegleria
gruberi) 		5 / 11 GLU A 227
PHE A 248
VAL A 281
VAL A 315
LYS A 317
 MN  A 401 ( 4.5A)
None
None
None
None
 0.47A 3qwuB-5covA:
15.4		 3qwuB-5covA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 5cov NAEGLERIA GRUBERI
RNA LIGASE
(Naegleria
gruberi) 		4 / 7 ILE A  56
PHE A 101
MET A  98
GLY A  47
 None
 1.15A 3sj0X-5covA:
undetectable		 3sj0X-5covA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 5cov NAEGLERIA GRUBERI
RNA LIGASE
(Naegleria
gruberi) 		5 / 9 LEU A  94
ILE A  15
GLY A  39
PRO A  97
LEU A  96
 None
 1.11A 3u7sA-5covA:
undetectable		 3u7sA-5covA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 5cov NAEGLERIA GRUBERI
RNA LIGASE
(Naegleria
gruberi) 		3 / 3 ARG A 149
ASP A 172
GLN A 234
 None
 0.77A 4azsA-5covA:
undetectable		 4azsA-5covA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 5cov NAEGLERIA GRUBERI
RNA LIGASE
(Naegleria
gruberi) 		4 / 6 ILE A 228
ILE A 126
SER A 131
LEU A 194
 None
 0.71A 4m51A-5covA:
undetectable		 4m51A-5covA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 5cov NAEGLERIA GRUBERI
RNA LIGASE
(Naegleria
gruberi) 		4 / 6 PHE A  50
THR A 114
ASP A 111
GLY A 110
 None
 1.23A 5mraA-5covA:
undetectable
5mraB-5covA:
undetectable		 5mraA-5covA:
18.79
5mraB-5covA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5cov NAEGLERIA GRUBERI
RNA LIGASE
(Naegleria
gruberi) 		3 / 3 GLN A  92
TRP A  32
VAL A  29
 None
 0.99A 6auuA-5covA:
undetectable		 6auuA-5covA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 5cov NAEGLERIA GRUBERI
RNA LIGASE
(Naegleria
gruberi) 		4 / 6 GLN A 202
ASN A 200
LEU A 130
SER A 131
 None
 1.25A 6ekuA-5covA:
undetectable		 6ekuA-5covA:
20.40