SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5coz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 5coz UNCHARACTERIZED
PROTEIN
([Eubacterium]
rectale) 		5 / 12 ILE A 110
ILE A 276
LEU A 106
LEU A 267
ILE A 204
 None
 1.01A 1bsxA-5cozA:
undetectable		 1bsxA-5cozA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 5coz UNCHARACTERIZED
PROTEIN
([Eubacterium]
rectale) 		5 / 12 ILE A 110
ILE A 276
LEU A 106
LEU A 267
ILE A 204
 None
 1.01A 1bsxB-5cozA:
undetectable		 1bsxB-5cozA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5coz UNCHARACTERIZED
PROTEIN
([Eubacterium]
rectale) 		4 / 6 TYR A 168
CYH A 251
TYR A 347
ILE A 380
 None
 1.28A 2xz5A-5cozA:
undetectable
2xz5B-5cozA:
undetectable		 2xz5A-5cozA:
19.76
2xz5B-5cozA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5coz UNCHARACTERIZED
PROTEIN
([Eubacterium]
rectale) 		4 / 7 TYR A 168
CYH A 251
TYR A 347
ILE A 380
 None
 1.24A 2xz5B-5cozA:
undetectable
2xz5E-5cozA:
undetectable		 2xz5B-5cozA:
19.76
2xz5E-5cozA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5coz UNCHARACTERIZED
PROTEIN
([Eubacterium]
rectale) 		4 / 7 VAL A 346
CYH A 251
TYR A 347
ILE A 380
 None
 1.30A 2xz5B-5cozA:
undetectable
2xz5E-5cozA:
undetectable		 2xz5B-5cozA:
19.76
2xz5E-5cozA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5coz UNCHARACTERIZED
PROTEIN
([Eubacterium]
rectale) 		4 / 8 ILE A 380
TYR A 168
CYH A 251
TYR A 347
 None
 1.30A 2xz5A-5cozA:
undetectable
2xz5C-5cozA:
undetectable		 2xz5A-5cozA:
19.76
2xz5C-5cozA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5coz UNCHARACTERIZED
PROTEIN
([Eubacterium]
rectale) 		4 / 8 ILE A 380
TYR A 168
CYH A 251
TYR A 347
 None
 1.30A 2xz5C-5cozA:
undetectable
2xz5D-5cozA:
undetectable		 2xz5C-5cozA:
19.76
2xz5D-5cozA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5coz UNCHARACTERIZED
PROTEIN
([Eubacterium]
rectale) 		4 / 8 THR A 234
GLN A 231
ASP A 272
SER A 277
 None
NA  A 401 (-2.8A)
None
None
 1.25A 2xz5C-5cozA:
undetectable
2xz5D-5cozA:
undetectable		 2xz5C-5cozA:
19.76
2xz5D-5cozA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5coz UNCHARACTERIZED
PROTEIN
([Eubacterium]
rectale) 		4 / 7 ILE A 380
TYR A 168
CYH A 251
TYR A 347
 None
 1.27A 2xz5D-5cozA:
undetectable
2xz5E-5cozA:
undetectable		 2xz5D-5cozA:
19.76
2xz5E-5cozA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5coz UNCHARACTERIZED
PROTEIN
([Eubacterium]
rectale) 		4 / 7 ILE A 380
VAL A 346
CYH A 251
TYR A 347
 None
 1.32A 2xz5D-5cozA:
undetectable
2xz5E-5cozA:
undetectable		 2xz5D-5cozA:
19.76
2xz5E-5cozA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5coz UNCHARACTERIZED
PROTEIN
([Eubacterium]
rectale) 		4 / 7 ILE A 380
SER A 249
TYR A 168
TYR A 347
 None
 1.35A 2xz5D-5cozA:
undetectable
2xz5E-5cozA:
undetectable		 2xz5D-5cozA:
19.76
2xz5E-5cozA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5coz UNCHARACTERIZED
PROTEIN
([Eubacterium]
rectale) 		4 / 8 VAL A 346
TYR A 168
CYH A 251
TYR A 347
 None
 1.22A 4bqtC-5cozA:
undetectable
4bqtD-5cozA:
undetectable		 4bqtC-5cozA:
19.24
4bqtD-5cozA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 5coz UNCHARACTERIZED
PROTEIN
([Eubacterium]
rectale) 		4 / 6 PRO A 283
TYR A 260
TYR A 285
TYR A 338
 None
 1.20A 4g10A-5cozA:
undetectable		 4g10A-5cozA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5coz UNCHARACTERIZED
PROTEIN
([Eubacterium]
rectale) 		4 / 6 GLU A 323
GLU A 211
TYR A 213
PHE A 238
 None
 1.44A 4twdG-5cozA:
undetectable
4twdH-5cozA:
undetectable		 4twdG-5cozA:
20.05
4twdH-5cozA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AIN_B_QMRB1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5coz UNCHARACTERIZED
PROTEIN
([Eubacterium]
rectale) 		5 / 10 VAL A 346
TYR A 168
CYH A 251
TYR A 347
ILE A 380
 None
 1.31A 5ainB-5cozA:
0.0
5ainC-5cozA:
0.0		 5ainB-5cozA:
21.19
5ainC-5cozA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AIN_E_QMRE1207_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5coz UNCHARACTERIZED
PROTEIN
([Eubacterium]
rectale) 		5 / 10 ILE A 380
VAL A 346
TYR A 168
CYH A 251
TYR A 347
 None
 1.35A 5ainA-5cozA:
0.0
5ainE-5cozA:
0.0		 5ainA-5cozA:
21.19
5ainE-5cozA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 5coz UNCHARACTERIZED
PROTEIN
([Eubacterium]
rectale) 		3 / 3 ASN A  91
SER A  93
ARG A 144
 None
 0.83A 5b2qA-5cozA:
undetectable		 5b2qA-5cozA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5coz UNCHARACTERIZED
PROTEIN
([Eubacterium]
rectale) 		4 / 4 ASN A 254
ILE A 340
TYR A 285
PHE A 240
 None
 1.50A 5igvA-5cozA:
2.4		 5igvA-5cozA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 5coz UNCHARACTERIZED
PROTEIN
([Eubacterium]
rectale) 		4 / 4 ASP A 371
ILE A 302
PRO A 299
LEU A 297
 None
 1.32A 6mkeB-5cozA:
undetectable		 6mkeB-5cozA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 5coz UNCHARACTERIZED
PROTEIN
([Eubacterium]
rectale) 		4 / 4 ASP A 371
ILE A 302
PRO A 299
LEU A 297
 None
 1.37A 6mkeA-5cozA:
undetectable		 6mkeA-5cozA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5coz UNCHARACTERIZED
PROTEIN
([Eubacterium]
rectale) 		4 / 6 ASP A 175
TYR A 349
GLU A 320
ASP A  69
 None
 1.05A 6mn5A-5cozA:
undetectable		 6mn5A-5cozA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 5coz UNCHARACTERIZED
PROTEIN
([Eubacterium]
rectale) 		4 / 6 THR A 234
LEU A 215
THR A 152
LEU A 221
 None
 1.22A 6mvxA-5cozA:
undetectable
6mvxB-5cozA:
undetectable
6mvxC-5cozA:
undetectable		 6mvxA-5cozA:
18.36
6mvxB-5cozA:
18.36
6mvxC-5cozA:
18.36