SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cqe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5cqe MATRIX PROTEIN 1
(Influenza
A
virus) 		5 / 12 GLY A 122
ALA A 123
SER A 126
GLY A 129
LEU A 130
 None
 0.94A 1fe2A-5cqeA:
undetectable		 1fe2A-5cqeA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5cqe MATRIX PROTEIN 1
(Influenza
A
virus) 		5 / 12 TYR A 132
ALA A 125
ALA A  96
GLY A  86
GLY A 122
 None
 1.05A 2igtA-5cqeA:
undetectable		 2igtA-5cqeA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5cqe MATRIX PROTEIN 1
(Influenza
A
virus) 		5 / 12 TYR A 132
ALA A 125
ALA A  96
GLY A  86
GLY A 122
 None
 1.05A 2igtB-5cqeA:
undetectable		 2igtB-5cqeA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 5cqe MATRIX PROTEIN 1
(Influenza
A
virus) 		4 / 8 ASP A 156
ALA A 155
SER A  13
TYR A  10
 None
 0.92A 3rodA-5cqeA:
undetectable		 3rodA-5cqeA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 5cqe MATRIX PROTEIN 1
(Influenza
A
virus) 		5 / 9 ALA A 123
LEU A 146
LEU A  84
ASN A  85
ILE A 131
 None
 1.22A 3wdmC-5cqeA:
undetectable		 3wdmC-5cqeA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5cqe MATRIX PROTEIN 1
(Influenza
A
virus) 		5 / 12 GLY A 122
ALA A 123
SER A 126
GLY A 129
LEU A 130
 None
 0.84A 4e1gA-5cqeA:
undetectable		 4e1gA-5cqeA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5cqe MATRIX PROTEIN 1
(Influenza
A
virus) 		5 / 12 GLY A 122
ALA A 123
SER A 126
GLY A 129
LEU A 130
 None
 0.82A 4e1gB-5cqeA:
undetectable		 4e1gB-5cqeA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5cqe MATRIX PROTEIN 1
(Influenza
A
virus) 		5 / 10 GLY A  61
THR A  56
VAL A  63
LEU A  52
LEU A  28
 None
 1.29A 4yb6B-5cqeA:
undetectable
4yb6C-5cqeA:
undetectable		 4yb6B-5cqeA:
20.72
4yb6C-5cqeA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5cqe MATRIX PROTEIN 1
(Influenza
A
virus) 		5 / 10 GLY A  61
THR A  56
VAL A  63
LEU A  52
LEU A  28
 None
 1.31A 4yb6C-5cqeA:
undetectable
4yb6F-5cqeA:
undetectable		 4yb6C-5cqeA:
20.72
4yb6F-5cqeA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5cqe MATRIX PROTEIN 1
(Influenza
A
virus) 		5 / 10 LEU A  52
LEU A  28
GLY A  61
THR A  56
VAL A  63
 None
 1.28A 4yb6A-5cqeA:
undetectable
4yb6D-5cqeA:
undetectable		 4yb6A-5cqeA:
20.72
4yb6D-5cqeA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5cqe MATRIX PROTEIN 1
(Influenza
A
virus) 		5 / 10 LEU A  52
LEU A  28
GLY A  61
THR A  56
VAL A  63
 None
 1.29A 4yb6D-5cqeA:
undetectable
4yb6E-5cqeA:
undetectable		 4yb6D-5cqeA:
20.72
4yb6E-5cqeA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5cqe MATRIX PROTEIN 1
(Influenza
A
virus) 		5 / 10 LEU A  52
LEU A  28
GLY A  61
THR A  56
VAL A  63
 None
 1.29A 4yb6B-5cqeA:
undetectable
4yb6F-5cqeA:
undetectable		 4yb6B-5cqeA:
20.72
4yb6F-5cqeA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5cqe MATRIX PROTEIN 1
(Influenza
A
virus) 		5 / 12 ALA A  83
PRO A  54
GLY A  61
GLY A  58
GLU A  71
 None
 1.03A 5c0oE-5cqeA:
undetectable		 5c0oE-5cqeA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 5cqe MATRIX PROTEIN 1
(Influenza
A
virus) 		4 / 7 GLY A  58
PHE A  62
ARG A  78
ASN A  85
 None
 1.07A 5n5dB-5cqeA:
undetectable		 5n5dB-5cqeA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5cqe MATRIX PROTEIN 1
(Influenza
A
virus) 		3 / 3 LYS A  95
ASN A  92
SER A 120
 None
 1.10A 5yw0A-5cqeA:
undetectable		 5yw0A-5cqeA:
21.17