SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cqr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 5cqr ELONGATOR COMPLEX
PROTEIN 1
(Homo
sapiens) 		4 / 4 HIS A1015
ALA A1010
PHE A1009
GLY A1013
 None
 1.34A 1mj2B-5cqrA:
undetectable		 1mj2B-5cqrA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 5cqr ELONGATOR COMPLEX
PROTEIN 1
(Homo
sapiens) 		4 / 4 HIS A1015
ALA A1010
PHE A1009
GLY A1013
 None
 1.41A 1mj2D-5cqrA:
undetectable		 1mj2D-5cqrA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 5cqr ELONGATOR COMPLEX
PROTEIN 1
(Homo
sapiens) 		4 / 4 HIS A1015
ALA A1010
PHE A1009
GLY A1013
 None
 1.37A 1mjoB-5cqrA:
undetectable		 1mjoB-5cqrA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 5cqr ELONGATOR COMPLEX
PROTEIN 1
(Homo
sapiens) 		4 / 4 HIS A1015
ALA A1010
PHE A1009
GLY A1013
 None
 1.40A 1mjoA-5cqrA:
undetectable		 1mjoA-5cqrA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 5cqr ELONGATOR COMPLEX
PROTEIN 1
(Homo
sapiens) 		4 / 4 HIS A1015
ALA A1010
PHE A1009
GLY A1013
 None
 1.37A 1mjoD-5cqrA:
undetectable		 1mjoD-5cqrA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 5cqr ELONGATOR COMPLEX
PROTEIN 1
(Homo
sapiens) 		3 / 3 THR A 795
THR A 793
PRO A 798
 None
 0.86A 1qfiB-5cqrA:
undetectable		 1qfiB-5cqrA:
1.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 5cqr ELONGATOR COMPLEX
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 918
LEU A 921
ASN A 922
LEU A 924
GLN A 932
 None
 0.94A 1sqnA-5cqrA:
undetectable		 1sqnA-5cqrA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 5cqr ELONGATOR COMPLEX
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 918
LEU A 921
ASN A 922
LEU A 924
GLN A 932
 None
 0.90A 3d90A-5cqrA:
undetectable		 3d90A-5cqrA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 5cqr ELONGATOR COMPLEX
PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU A1255
LEU A1240
ILE A1239
LEU A1232
LEU A1263
 None
 0.96A 4dm8A-5cqrA:
undetectable		 4dm8A-5cqrA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 5cqr ELONGATOR COMPLEX
PROTEIN 1
(Homo
sapiens) 		4 / 5 ILE A 947
ASN A 972
TYR A 971
ILE A 965
 None
 0.86A 4jtpA-5cqrA:
undetectable		 4jtpA-5cqrA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 5cqr ELONGATOR COMPLEX
PROTEIN 1
(Homo
sapiens) 		3 / 3 TYR A1099
ARG A1094
LYS A1098
 None
 1.44A 4wq5B-5cqrA:
undetectable		 4wq5B-5cqrA:
21.25