SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cqs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5cqs ELONGATOR COMPLEX
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 4 THR A1269
LEU A1266
VAL A1299
LEU A1302
 None
 0.94A 1mz9D-5cqsA:
undetectable		 1mz9D-5cqsA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 5cqs ELONGATOR COMPLEX
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 968
GLU A 982
SER A 985
VAL A 997
 None
 1.31A 3n61A-5cqsA:
undetectable
3n61B-5cqsA:
undetectable		 3n61A-5cqsA:
20.34
3n61B-5cqsA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5cqs ELONGATOR COMPLEX
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 968
GLU A 982
SER A 985
VAL A 997
 None
 1.33A 3nlyA-5cqsA:
undetectable
3nlyB-5cqsA:
undetectable		 3nlyA-5cqsA:
20.34
3nlyB-5cqsA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5cqs ELONGATOR COMPLEX
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 5 VAL A1143
SER A1127
GLY A1279
ARG A1282
 None
 1.01A 3v4tA-5cqsA:
undetectable
3v4tD-5cqsA:
undetectable		 3v4tA-5cqsA:
22.13
3v4tD-5cqsA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 5cqs ELONGATOR COMPLEX
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 958
LEU A 955
LEU A 952
VAL A 921
MET A 946
 None
 1.17A 3zqtA-5cqsA:
undetectable		 3zqtA-5cqsA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5cqs ELONGATOR COMPLEX
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 968
GLU A 982
SER A 985
VAL A 997
 None
 1.32A 4capA-5cqsA:
undetectable
4capB-5cqsA:
undetectable		 4capA-5cqsA:
20.34
4capB-5cqsA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5cqs ELONGATOR COMPLEX
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 968
GLU A 982
SER A 985
VAL A 997
 None
 1.30A 4d32A-5cqsA:
undetectable
4d32B-5cqsA:
undetectable		 4d32A-5cqsA:
20.34
4d32B-5cqsA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5cqs ELONGATOR COMPLEX
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 10 LEU A1011
GLY A1010
VAL A 993
ILE A 998
VAL A 997
 None
 1.12A 4jx1B-5cqsA:
undetectable		 4jx1B-5cqsA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5cqs ELONGATOR COMPLEX
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 968
GLU A 982
SER A 985
VAL A 997
 None
 1.30A 4v3yA-5cqsA:
undetectable
4v3yB-5cqsA:
undetectable		 4v3yA-5cqsA:
20.34
4v3yB-5cqsA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5cqs ELONGATOR COMPLEX
PROTEIN 1
(Saccharomyces
cerevisiae) 		4 / 8 SER A 985
VAL A 997
PHE A 968
GLU A 982
 None
 1.31A 5uo7A-5cqsA:
undetectable
5uo7B-5cqsA:
undetectable		 5uo7A-5cqsA:
20.39
5uo7B-5cqsA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5cqs ELONGATOR COMPLEX
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 9 TYR A1123
ASP A1272
ALA A1289
GLY A1150
GLY A1279
 None
 1.36A 6awoA-5cqsA:
undetectable		 6awoA-5cqsA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5cqs ELONGATOR COMPLEX
PROTEIN 1
(Saccharomyces
cerevisiae) 		5 / 9 TYR A1123
ASP A1272
ALA A1289
GLY A1150
GLY A1279
 None
 1.36A 6awqA-5cqsA:
undetectable		 6awqA-5cqsA:
21.02