SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cr4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2U_A_ELVA397_1
(INTEGRASE)		 5cr4 SLEEPING BEAUTY
TRANSPOSASE, SB100X
(synthetic
construct) 		4 / 5 ASP A  43
ASP A 134
PRO A 163
GLU A 169
 GOL  A 317 (-4.2A)
SO4  A 309 ( 3.9A)
GOL  A 317 (-3.8A)
GOL  A 317 (-4.0A)
 0.73A 3l2uA-5cr4A:
11.2		 3l2uA-5cr4A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 5cr4 SLEEPING BEAUTY
TRANSPOSASE, SB100X
(synthetic
construct) 		4 / 7 ASP A  43
ASP A 134
PRO A 163
GLU A 169
 GOL  A 317 (-4.2A)
SO4  A 309 ( 3.9A)
GOL  A 317 (-3.8A)
GOL  A 317 (-4.0A)
 0.74A 3l2vA-5cr4A:
11.2		 3l2vA-5cr4A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2W_A_ELVA397_1
(INTEGRASE)		 5cr4 SLEEPING BEAUTY
TRANSPOSASE, SB100X
(synthetic
construct) 		4 / 5 ASP A  43
ASP A 134
PRO A 163
GLU A 169
 GOL  A 317 (-4.2A)
SO4  A 309 ( 3.9A)
GOL  A 317 (-3.8A)
GOL  A 317 (-4.0A)
 0.66A 3l2wA-5cr4A:
8.4		 3l2wA-5cr4A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 5cr4 SLEEPING BEAUTY
TRANSPOSASE, SB100X
(synthetic
construct) 		4 / 8 ASP A  43
ASP A 134
PRO A 163
GLU A 169
 GOL  A 317 (-4.2A)
SO4  A 309 ( 3.9A)
GOL  A 317 (-3.8A)
GOL  A 317 (-4.0A)
 0.67A 3oyaA-5cr4A:
11.1		 3oyaA-5cr4A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 5cr4 SLEEPING BEAUTY
TRANSPOSASE, SB100X
(synthetic
construct) 		4 / 8 ASP A  43
ASP A 134
PRO A 163
GLU A 169
 GOL  A 317 (-4.2A)
SO4  A 309 ( 3.9A)
GOL  A 317 (-3.8A)
GOL  A 317 (-4.0A)
 0.61A 3s3mA-5cr4A:
11.1		 3s3mA-5cr4A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 5cr4 SLEEPING BEAUTY
TRANSPOSASE, SB100X
(synthetic
construct) 		4 / 8 ASP A  43
ASP A 134
PRO A 163
GLU A 169
 GOL  A 317 (-4.2A)
SO4  A 309 ( 3.9A)
GOL  A 317 (-3.8A)
GOL  A 317 (-4.0A)
 0.59A 3s3nA-5cr4A:
11.1		 3s3nA-5cr4A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 5cr4 SLEEPING BEAUTY
TRANSPOSASE, SB100X
(synthetic
construct) 		4 / 7 ASP A  43
ASP A 134
PRO A 163
GLU A 169
 GOL  A 317 (-4.2A)
SO4  A 309 ( 3.9A)
GOL  A 317 (-3.8A)
GOL  A 317 (-4.0A)
 0.58A 3s3oA-5cr4A:
11.2		 3s3oA-5cr4A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5cr4 SLEEPING BEAUTY
TRANSPOSASE, SB100X
(synthetic
construct) 		3 / 3 ARG A 182
ARG A 178
LYS A 200
 None
SO4  A 306 (-2.7A)
None
 1.48A 3w1wA-5cr4A:
undetectable
3w1wB-5cr4A:
undetectable		 3w1wA-5cr4A:
21.11
3w1wB-5cr4A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5cr4 SLEEPING BEAUTY
TRANSPOSASE, SB100X
(synthetic
construct) 		5 / 12 LEU A  96
ASP A  43
ASN A 166
ARG A 216
GLU A 169
 None
GOL  A 317 (-4.2A)
GOL  A 317 (-3.9A)
None
GOL  A 317 (-4.0A)
 1.42A 4zjlD-5cr4A:
1.3		 4zjlD-5cr4A:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 5cr4 SLEEPING BEAUTY
TRANSPOSASE, SB100X
(synthetic
construct) 		4 / 6 GLU A 174
ALA A 173
LEU A 171
TYR A 205
 None
 0.79A 5phhA-5cr4A:
undetectable		 5phhA-5cr4A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5cr4 SLEEPING BEAUTY
TRANSPOSASE, SB100X
(synthetic
construct) 		3 / 3 ARG A 180
LYS A 176
ARG A 216
 None
GOL  A 314 ( 4.3A)
None
 1.35A 6c06D-5cr4A:
undetectable		 6c06D-5cr4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5cr4 SLEEPING BEAUTY
TRANSPOSASE, SB100X
(synthetic
construct) 		4 / 6 VAL A 220
PRO A  11
ALA A  25
THR A  26
 None
 1.01A 6cduB-5cr4A:
undetectable
6cduC-5cr4A:
undetectable		 6cduB-5cr4A:
20.72
6cduC-5cr4A:
20.72