SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5crj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5crj TRANSCRIPTION
TERMINATION FACTOR
1, MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 TYR O 317
ILE O 296
ILE O 332
PHE O 313
 None
 0.76A 3uqbA-5crjO:
undetectable		 3uqbA-5crjO:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 5crj TRANSCRIPTION
TERMINATION FACTOR
1, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 TYR O 317
ILE O 296
LYS O 331
ILE O 332
PHE O 313
 None
 1.25A 4drhA-5crjO:
undetectable		 4drhA-5crjO:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 5crj TRANSCRIPTION
TERMINATION FACTOR
1, MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 TYR O 317
ILE O 296
LYS O 331
ILE O 332
PHE O 313
 None
 1.04A 4drjA-5crjO:
undetectable		 4drjA-5crjO:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 5crj TRANSCRIPTION
TERMINATION FACTOR
1, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 TYR O 317
ILE O 296
LYS O 331
ILE O 332
PHE O 313
 None
 1.15A 4nnrA-5crjO:
undetectable
4nnrB-5crjO:
undetectable		 4nnrA-5crjO:
17.13
4nnrB-5crjO:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 5crj TRANSCRIPTION
TERMINATION FACTOR
1, MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 TYR O 317
ILE O 296
LYS O 331
ILE O 332
PHE O 313
 None
 1.08A 4nnrB-5crjO:
undetectable		 4nnrB-5crjO:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 5crj TRANSCRIPTION
TERMINATION FACTOR
1, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG O 350
GLU O 280
TYR O 317
 None
 0.95A 4r29D-5crjO:
undetectable		 4r29D-5crjO:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 5crj TRANSCRIPTION
TERMINATION FACTOR
1, MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ILE O 342
THR O 306
GLY O 304
GLU O 309
GLU O 347
 None
 1.34A 4xt7A-5crjO:
undetectable		 4xt7A-5crjO:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_I_PACI601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 5crj TRANSCRIPTION
TERMINATION FACTOR
1, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 SER O 292
PHE O 258
PHE O 263
ILE O 281
VAL O 320
 None
 1.46A 4yfbI-5crjO:
undetectable		 4yfbI-5crjO:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_L_PACL601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 5crj TRANSCRIPTION
TERMINATION FACTOR
1, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 SER O 292
PHE O 258
PHE O 263
ILE O 281
VAL O 320
 None
 1.48A 4yfbL-5crjO:
undetectable		 4yfbL-5crjO:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5crj TRANSCRIPTION
TERMINATION FACTOR
1, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 VAL O 150
LEU O 197
ILE O 121
SER O 163
ILE O 156
 None
 1.13A 5hbsA-5crjO:
undetectable		 5hbsA-5crjO:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 5crj TRANSCRIPTION
TERMINATION FACTOR
1, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LYS O 312
GLN O 344
ASN O 348
 None
 1.01A 5l2tA-5crjO:
undetectable		 5l2tA-5crjO:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 5crj TRANSCRIPTION
TERMINATION FACTOR
1, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 PHE O 233
ASP O 232
LYS O 236
 None
 0.88A 6awtD-5crjO:
undetectable		 6awtD-5crjO:
21.14