SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5crv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 5crv TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 23
(Homo
sapiens) 		4 / 7 ALA A  55
TYR A  71
ARG A  52
TYR A 119
 None
 1.16A 2ajvH-5crvA:
undetectable
2ajvL-5crvA:
undetectable		 2ajvH-5crvA:
19.48
2ajvL-5crvA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5crv TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 23
SIGNAL TRANSDUCING
ADAPTER MOLECULE 2
(Homo
sapiens;
Homo
sapiens) 		4 / 8 ARG A   6
LEU C 358
GLU A 191
SER A 193
 None
 1.08A 2zw9A-5crvA:
undetectable		 2zw9A-5crvA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 5crv TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 23
(Homo
sapiens) 		3 / 3 ILE A 206
MET A 140
ARG A 134
 None
 0.76A 4lnwA-5crvA:
undetectable		 4lnwA-5crvA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 5crv TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 23
(Homo
sapiens) 		3 / 3 ILE A 206
MET A 140
ARG A 134
 None
 0.76A 4lnxA-5crvA:
undetectable		 4lnxA-5crvA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5crv TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 23
(Homo
sapiens) 		5 / 12 GLY A  73
LEU A  68
ILE A 356
THR A 352
GLY A 353
 None
 0.93A 5d4uB-5crvA:
undetectable		 5d4uB-5crvA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5crv TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 23
(Homo
sapiens) 		5 / 12 GLY A  73
LEU A  68
ILE A 356
THR A 352
GLY A 353
 None
 0.95A 5d4uC-5crvA:
undetectable		 5d4uC-5crvA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 5crv TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 23
(Homo
sapiens) 		5 / 12 TYR A 247
THR A 293
ALA A 297
GLY A 289
ALA A 287
 None
 1.13A 5lf7V-5crvA:
undetectable
5lf7b-5crvA:
undetectable		 5lf7V-5crvA:
20.00
5lf7b-5crvA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 5crv TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 23
(Homo
sapiens) 		5 / 12 TYR A 247
THR A 293
ALA A 297
GLY A 289
ALA A 287
 None
 1.12A 5lf7H-5crvA:
undetectable
5lf7N-5crvA:
undetectable		 5lf7H-5crvA:
20.00
5lf7N-5crvA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 5crv TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 23
(Homo
sapiens) 		4 / 8 ALA A 297
ILE A 284
ALA A 283
LEU A 280
 None
 0.71A 5te8B-5crvA:
0.6		 5te8B-5crvA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 5crv TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 23
(Homo
sapiens) 		4 / 8 LEU A 180
GLN A 184
ALA A 185
PHE A 147
 None
 0.98A 5xu8A-5crvA:
undetectable		 5xu8A-5crvA:
21.20