SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cs0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 5cs0 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 884
LEU A 907
ILE A 847
VAL A 866
PHE A 876
 None
 1.05A 1gx8A-5cs0A:
undetectable		 1gx8A-5cs0A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 5cs0 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 854
LEU A 858
VAL A 866
LEU A 881
LEU A 884
 None
 1.14A 1sn5B-5cs0A:
undetectable
1sn5D-5cs0A:
undetectable		 1sn5B-5cs0A:
16.87
1sn5D-5cs0A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 5cs0 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 900
LEU A 850
MET A 862
 None
 0.80A 1ya3B-5cs0A:
undetectable		 1ya3B-5cs0A:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5cs0 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 999
LYS A 998
HIS A 921
 None
 0.89A 3elzA-5cs0A:
undetectable		 3elzA-5cs0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5cs0 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 838
TYR A 840
LEU A 918
TYR A 914
 None
 0.92A 4f3tA-5cs0A:
undetectable		 4f3tA-5cs0A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 5cs0 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 842
PHE A 876
LYS A 913
HIS A 921
 None
 1.21A 4uciB-5cs0A:
undetectable		 4uciB-5cs0A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5cs0 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 838
TYR A 840
LEU A 918
TYR A 914
 None
 0.95A 4z4fA-5cs0A:
undetectable		 4z4fA-5cs0A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 5cs0 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 876
HIS A 912
LEU A 907
PRO A 877
 None
 1.43A 5csyB-5cs0A:
undetectable		 5csyB-5cs0A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5cs0 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 SER A 848
LEU A 881
MET A 862
 None
 0.84A 5ikrB-5cs0A:
undetectable		 5ikrB-5cs0A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5cs0 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 838
TYR A 840
LEU A 918
TYR A 914
 None
 0.90A 5ki6A-5cs0A:
undetectable		 5ki6A-5cs0A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5cs0 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 838
TYR A 840
LEU A 918
TYR A 914
 None
 0.88A 5t7bA-5cs0A:
undetectable		 5t7bA-5cs0A:
14.07