SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cs2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 5cs2 HISTIDINE TRIAD
PROTEIN
(Plasmodium
falciparum) 		4 / 4 LEU A 189
SER A 192
TYR A 193
LEU A  91
 None
 1.13A 1xz1A-5cs2A:
undetectable		 1xz1A-5cs2A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 5cs2 HISTIDINE TRIAD
PROTEIN
(Plasmodium
falciparum) 		4 / 4 LEU A 189
SER A 192
TYR A 193
LEU A  91
 None
 1.13A 1xz3A-5cs2A:
undetectable		 1xz3A-5cs2A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 5cs2 HISTIDINE TRIAD
PROTEIN
(Plasmodium
falciparum) 		5 / 10 PHE A  24
ILE A  29
LEU A  56
HIS A 115
HIS A 117
 None
 0.55A 3o1cA-5cs2A:
10.2		 3o1cA-5cs2A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 5cs2 HISTIDINE TRIAD
PROTEIN
(Plasmodium
falciparum) 		5 / 10 PHE A  24
ILE A  29
LEU A  56
HIS A 115
HIS A 117
 None
 0.53A 3o1xA-5cs2A:
10.1		 3o1xA-5cs2A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 5cs2 HISTIDINE TRIAD
PROTEIN
(Plasmodium
falciparum) 		5 / 10 PHE A  24
ILE A  29
LEU A  56
HIS A 115
HIS A 117
 None
 0.53A 3qgzA-5cs2A:
10.2		 3qgzA-5cs2A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 5cs2 HISTIDINE TRIAD
PROTEIN
(Plasmodium
falciparum) 		4 / 8 ALA A 107
GLN A 109
HIS A 115
HIS A 117
 None
 1.06A 5km8A-5cs2A:
11.0
5km8B-5cs2A:
10.7		 5km8A-5cs2A:
16.06
5km8B-5cs2A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 5cs2 HISTIDINE TRIAD
PROTEIN
(Plasmodium
falciparum) 		6 / 12 PHE A  24
ILE A  29
LEU A  56
VAL A 111
HIS A 115
HIS A 117
 None
None
None
CL  A1000 ( 3.9A)
None
None
 0.43A 5km9B-5cs2A:
10.8		 5km9B-5cs2A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 5cs2 HISTIDINE TRIAD
PROTEIN
(Plasmodium
falciparum) 		7 / 12 PHE A  24
ILE A  29
LEU A  56
THR A 110
VAL A 111
HIS A 115
HIS A 117
 None
None
None
None
CL  A1000 ( 3.9A)
None
None
 0.39A 5uvmB-5cs2A:
10.3		 5uvmB-5cs2A:
20.95