SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5cs4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 5cs4 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 ILE A1385
PHE A1407
PHE A1404
PHE A1389
 None
 1.14A 1e71M-5cs4A:
undetectable		 1e71M-5cs4A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 5cs4 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 ILE A1385
PHE A1407
PHE A1404
PHE A1389
 None
 1.14A 1e72M-5cs4A:
undetectable		 1e72M-5cs4A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 5cs4 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1040
GLY A1270
ASP A1084
 None
 0.57A 1kf6A-5cs4A:
2.4
1kf6B-5cs4A:
undetectable		 1kf6A-5cs4A:
20.59
1kf6B-5cs4A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5cs4 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 4 THR A1229
LEU A1183
VAL A1186
LEU A1190
 None
 0.94A 1mz9D-5cs4A:
undetectable		 1mz9D-5cs4A:
6.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 5cs4 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1173
ILE A1115
TRP A1131
 None
 0.93A 1nodB-5cs4A:
1.3		 1nodB-5cs4A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 5cs4 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1173
ILE A1115
TRP A1131
 None
 1.04A 1qomA-5cs4A:
1.3		 1qomA-5cs4A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 5cs4 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A1305
ALA A1325
SER A1327
SER A1330
 None
 1.02A 1tz8C-5cs4A:
undetectable
1tz8D-5cs4A:
undetectable		 1tz8C-5cs4A:
15.13
1tz8D-5cs4A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 5cs4 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1173
ILE A1115
TRP A1131
 None
 0.94A 2nodB-5cs4A:
1.6		 2nodB-5cs4A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 5cs4 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 9 THR A1229
VAL A1186
SER A1191
ILE A1261
ILE A1238
 None
 1.22A 3cv9A-5cs4A:
undetectable		 3cv9A-5cs4A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5cs4 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1173
ILE A1115
TRP A1131
 None
 0.90A 3e7iB-5cs4A:
undetectable		 3e7iB-5cs4A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5cs4 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 ASP A1269
LEU A1075
PRO A1273
GLY A1266
LEU A1087
 None
 1.29A 3j6pB-5cs4A:
undetectable		 3j6pB-5cs4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 5cs4 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 9 ALA A1361
ILE A1385
GLY A1340
ILE A1341
ILE A1425
 None
 1.08A 3ndwB-5cs4A:
undetectable		 3ndwB-5cs4A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5cs4 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1173
ILE A1115
TRP A1131
 None
 1.02A 3nw2A-5cs4A:
0.9		 3nw2A-5cs4A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5cs4 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1173
ILE A1115
TRP A1131
 None
 0.95A 3nw2B-5cs4A:
1.6		 3nw2B-5cs4A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 5cs4 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A1086
ALA A1102
MET A1264
ASN A1223
 None
 1.49A 3uq6A-5cs4A:
undetectable		 3uq6A-5cs4A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5cs4 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A1191
LEU A1194
SER A1193
ILE A1245
VAL A1180
 None
 1.10A 3w68A-5cs4A:
2.2		 3w68A-5cs4A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 5cs4 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 ARG A1441
LEU A1443
TYR A1487
HIS A1384
 None
 1.00A 3zmdA-5cs4A:
undetectable
3zmdB-5cs4A:
undetectable		 3zmdA-5cs4A:
17.20
3zmdB-5cs4A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 5cs4 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A1361
ILE A1385
GLY A1340
ILE A1341
ILE A1425
 None
 1.11A 4njvD-5cs4A:
undetectable		 4njvD-5cs4A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5cs4 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 11 ILE A1425
PHE A1407
ILE A1368
ILE A1387
THR A1454
 None
 1.35A 4p68A-5cs4A:
undetectable		 4p68A-5cs4A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 5cs4 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 PHE A1133
TYR A1110
ALA A1295
ARG A1260
 None
 1.31A 4yshB-5cs4A:
undetectable		 4yshB-5cs4A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 5cs4 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 9 ALA A1361
ILE A1385
GLY A1340
ILE A1341
ILE A1425
 None
 1.18A 5kr0A-5cs4A:
undetectable		 5kr0A-5cs4A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 5cs4 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 4 ARG A1304
GLU A1301
GLU A1424
ARG A1441
 None
 1.15A 6fk2A-5cs4A:
undetectable		 6fk2A-5cs4A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 5cs4 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 4 ARG A1441
GLU A1424
GLU A1301
ARG A1304
 None
 1.09A 6fk2A-5cs4A:
undetectable		 6fk2A-5cs4A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 5cs4 ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 LYS A1173
SER A1257
SER A1219
 None
 1.09A 6gbfA-5cs4A:
undetectable		 6gbfA-5cs4A:
21.92