SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5csa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 ILE A1385
PHE A1407
PHE A1404
PHE A1389
 None
 1.08A 1e71M-5csaA:
undetectable		 1e71M-5csaA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 ILE A1385
PHE A1407
PHE A1404
PHE A1389
 None
 1.08A 1e72M-5csaA:
undetectable		 1e72M-5csaA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 4 THR A1229
LEU A1183
VAL A1186
LEU A1190
 None
 0.97A 1mz9D-5csaA:
undetectable		 1mz9D-5csaA:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1173
ILE A1115
TRP A1131
 None
 1.09A 1nodB-5csaA:
1.6		 1nodB-5csaA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1173
ILE A1115
TRP A1131
 None
 1.20A 1qomA-5csaA:
1.7		 1qomA-5csaA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1177
VAL A1129
TYR A1105
LEU A1069
LEU A1072
 None
 1.09A 1s19A-5csaA:
undetectable		 1s19A-5csaA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 TRP A 843
ALA A 911
PRO A 877
ALA A 878
 None
 0.95A 2ejfA-5csaA:
undetectable		 2ejfA-5csaA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 11 ALA A1361
ILE A1385
GLY A1340
ILE A1341
ILE A1425
 None
 1.12A 2idwA-5csaA:
undetectable		 2idwA-5csaA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1173
ILE A1115
TRP A1131
 None
 1.08A 2nodB-5csaA:
1.7		 2nodB-5csaA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A1361
ILE A1385
GLY A1340
ILE A1341
ILE A1425
 None
 1.05A 2o4kA-5csaA:
undetectable		 2o4kA-5csaA:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 TRP A 843
ALA A 911
PRO A 877
ALA A 878
 None
 0.95A 2zgwA-5csaA:
undetectable		 2zgwA-5csaA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 TRP A 843
ALA A 911
PRO A 877
ALA A 878
 None
 0.99A 2zgwB-5csaA:
undetectable		 2zgwB-5csaA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 THR A1288
SER A1306
LYS A1328
 None
 0.89A 3aocC-5csaA:
3.0		 3aocC-5csaA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 9 THR A1229
VAL A1186
SER A1191
ILE A1261
ILE A1238
 None
 1.27A 3cv9A-5csaA:
undetectable		 3cv9A-5csaA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1173
ILE A1115
TRP A1131
 None
 1.09A 3e7iB-5csaA:
undetectable		 3e7iB-5csaA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A1271
LEU A1090
LEU A1086
PHE A1083
CYH A1225
 None
 1.18A 3ko0M-5csaA:
undetectable
3ko0N-5csaA:
undetectable
3ko0O-5csaA:
undetectable
3ko0P-5csaA:
undetectable		 3ko0M-5csaA:
9.66
3ko0N-5csaA:
9.66
3ko0O-5csaA:
9.66
3ko0P-5csaA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 634
LEU A 694
ILE A 582
GLY A 584
ALA A 586
 None
 0.98A 3n8zB-5csaA:
undetectable		 3n8zB-5csaA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 9 ALA A1361
ILE A1385
GLY A1340
ILE A1341
ILE A1425
 None
 1.03A 3ndwB-5csaA:
undetectable		 3ndwB-5csaA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 9 ALA A1361
ILE A1385
GLY A1340
ILE A1341
ILE A1425
 None
 1.12A 3nuoA-5csaA:
undetectable		 3nuoA-5csaA:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1173
ILE A1115
TRP A1131
 None
 1.14A 3nw2A-5csaA:
1.8		 3nw2A-5csaA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1173
ILE A1115
TRP A1131
 None
 1.09A 3nw2B-5csaA:
1.8		 3nw2B-5csaA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 955
LEU A 962
VAL A 965
ASP A 956
 None
 1.07A 3ufnA-5csaA:
undetectable
3ufnB-5csaA:
undetectable		 3ufnA-5csaA:
7.61
3ufnB-5csaA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 ALA A1403
MET A1456
THR A1454
PHE A1404
 None
 1.19A 3vasB-5csaA:
undetectable		 3vasB-5csaA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 838
LEU A 833
LEU A 805
SER A 804
 None
 1.04A 3vhuA-5csaA:
undetectable		 3vhuA-5csaA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A1191
LEU A1194
SER A1193
ILE A1245
VAL A1180
 None
 1.08A 3w68A-5csaA:
3.3		 3w68A-5csaA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 ARG A1441
LEU A1443
TYR A1487
HIS A1384
 None
 1.02A 3zmdA-5csaA:
undetectable
3zmdB-5csaA:
undetectable		 3zmdA-5csaA:
10.96
3zmdB-5csaA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 912
LEU A 850
LEU A 900
ASP A 859
 None
 0.95A 4aqlA-5csaA:
undetectable		 4aqlA-5csaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 838
TYR A 840
LEU A 918
TYR A 914
 None
 1.00A 4f3tA-5csaA:
undetectable		 4f3tA-5csaA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 667
LEU A 785
THR A 587
ILE A 674
VAL A 687
 None
 0.92A 4h1nA-5csaA:
0.1		 4h1nA-5csaA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 MET A 862
LEU A 865
ARG A 868
ILE A 885
LEU A 881
 None
 1.23A 4j24D-5csaA:
undetectable		 4j24D-5csaA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 833
LEU A 838
ILE A 925
THR A 796
HIS A 846
 None
 1.36A 4mk4A-5csaA:
undetectable		 4mk4A-5csaA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 884
ARG A 868
GLU A 863
ALA A 856
 None
 1.00A 4nkxA-5csaA:
undetectable		 4nkxA-5csaA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A1032
GLN A1031
ALA A1033
TYR A1080
ASN A1317
 None
 1.31A 4pb1A-5csaA:
undetectable		 4pb1A-5csaA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 838
TYR A 840
LEU A 918
TYR A 914
 None
 1.04A 4z4fA-5csaA:
2.3		 4z4fA-5csaA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 876
HIS A 912
LEU A 907
PRO A 877
 None
 1.47A 5csyB-5csaA:
undetectable		 5csyB-5csaA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 838
TYR A 840
LEU A 918
TYR A 914
 None
 0.99A 5ki6A-5csaA:
2.9		 5ki6A-5csaA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A1361
ILE A1385
GLY A1340
ILE A1341
ILE A1425
 None
 1.08A 5kqyA-5csaA:
undetectable		 5kqyA-5csaA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 9 ALA A1361
ILE A1385
GLY A1340
ILE A1341
ILE A1425
 None
 1.10A 5kr0A-5csaA:
undetectable		 5kr0A-5csaA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1086
ALA A1101
PRO A1067
SER A1051
ILE A1076
 None
 1.17A 5ljbA-5csaA:
undetectable		 5ljbA-5csaA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1086
ALA A1101
PRO A1067
SER A1051
ILE A1076
 None
 1.17A 5ljcA-5csaA:
undetectable		 5ljcA-5csaA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 HIS A 625
VAL A 581
LEU A 685
THR A 692
 None
 1.28A 5ogjA-5csaA:
undetectable		 5ogjA-5csaA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_B_ACTB305_0
(CARBONIC ANHYDRASE
13)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 HIS A 625
VAL A 581
LEU A 685
THR A 692
 None
 1.28A 5ogjB-5csaA:
undetectable		 5ogjB-5csaA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 625
VAL A 581
LEU A 685
THR A 692
 None
 1.28A 5ohhA-5csaA:
undetectable		 5ohhA-5csaA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_B_ACTB311_0
(CARBONIC ANHYDRASE
13)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 HIS A 625
VAL A 581
LEU A 685
THR A 692
 None
 1.28A 5ohhB-5csaA:
undetectable		 5ohhB-5csaA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 838
TYR A 840
LEU A 918
TYR A 914
 None
 0.95A 5t7bA-5csaA:
2.7		 5t7bA-5csaA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 MET A 862
LEU A 865
ARG A 868
ILE A 885
LEU A 881
 None
 1.09A 5toaB-5csaA:
undetectable		 5toaB-5csaA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 9 LEU A1357
THR A1358
GLY A1405
PHE A1389
ILE A1425
 None
 1.33A 6ebpA-5csaA:
undetectable		 6ebpA-5csaA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 4 ARG A1304
GLU A1301
GLU A1424
ARG A1441
 None
 1.24A 6fk2A-5csaA:
undetectable		 6fk2A-5csaA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 5csa ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 4 ARG A1441
GLU A1424
GLU A1301
ARG A1304
 None
 1.31A 6fk2A-5csaA:
undetectable		 6fk2A-5csaA:
9.90